HDL biology
A review names CETP, LCAT, and lipases as the enzymes driving HDL subclass interconversion in mature HDL formation and reverse cholesterol transport (Curr Opin Lipidol 1994)
Original title: High-density lipoprotein subclasses
This review describes recent advances in separating HDL subfractions by physicochemical and immunological methods and the relationships between particles obtained by different procedures. The metabolic interconversions driven by cholesteryl ester transfer protein (CETP), lecithin:cholesterol acyltransferase (LCAT), and lipase activities, and their role in forming mature HDL and in reverse cholesterol transport, are discussed. The review also considers alterations in the HDL subpopulation profile seen in coronary heart disease and possible mechanisms by which HDL may protect against this condition.
Original abstract
This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP), lecithin:cholesterol acyltransferase (LCAT) and lipase activities and their role in the formation of mature HDL and in reverse cholesterol transport are discussed. Also considered are the alterations that occur in the HDL subpopulation profile in coronary heart disease and possible mechanisms by which HDL may protect against this condition.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.