HDL biology
Net cholesteryl ester transfer is elevated in hypertriglyceridemic hemodialysis patients, tracking triglyceride levels rather than renal status (Am J Nephrol 1996)
Original title: Neutral-lipid transfers and cholesteryl ester transfer protein in hemodialyzed patients
Net neutral-lipid transfers and CETP activity and mass were investigated in 20 hemodialyzed patients, divided into two groups by fasting triglyceride level, and compared with triglyceride-matched control groups. In hypertriglyceridemic subjects (plasma triglycerides above 150 mg/dl), HDL cholesterol was decreased and net cholesteryl ester transfer rates were significantly higher than in normolipidemic subjects. When subjects were matched for plasma triglyceride and cholesterol levels, there was no significant difference in cholesteryl ester or triglyceride transfer rates between hemodialysis patients and controls. The authors conclude that normal or elevated net neutral-lipid transfers reflect plasma triglyceride levels rather than renal status.
Original abstract
Abnormalities in cholesteryl ester transfers may play a role in the development of atherosclerosis observed in patients with end-stage renal failure treated by chronic hemodialysis. Net neutral-lipid transfers and cholesteryl ester transfer protein activity and mass were investigated in 20 hemodialyzed patients, arbitrarily divided into two groups based on fasting triglyceride levels, and compared to triglyceride-matched control groups. In the hypertriglyceridemic subjects (plasma triglyceride values > 150 mg/dl), high-density lipoprotein cholesterol was decreased, and the net cholesteryl ester transfer rates were significantly higher than the rates in normolipidemic subjects. The comparison of subjects matched for plasma triglyceride and cholesterol levels showed no significant difference in cholesteryl ester or triglyceride transfer rates between patients and controls. Our results suggest that normal or elevated net neutral-lipid transfers are not related to the renal status of the subjects, but rather to their plasma triglyceride levels.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.