HDL biology
A review by Barter and Rye finds continuing conflict in the evidence on whether cholesteryl ester transfer protein is atherogenic or anti-atherogenic (Curr Opin Lipidol 2001)
Original title: Cholesteryl ester transfer protein, high density lipoprotein and arterial disease
This Current Opinion in Lipidology review by Barter and Rye examines the confusing and conflicting relationships reported between cholesteryl ester transfer protein (CETP), high-density lipoproteins, and arterial disease. Several papers published during the review period substantially add to the evidence base regarding the atherogenicity or anti-atherogenicity of CETP, but none clearly resolves the ongoing conflict. The authors present these new findings against the backdrop of the previous state of knowledge, without endorsing either a proatherogenic or antiatherogenic conclusion for CETP.
Original abstract
The reported relationships between cholesteryl ester transfer protein, high density lipoproteins and arterial disease are confusing and conflicting. Several papers published during the review period add substantially to the evidence base regarding the atherogenicity (or anti-atherogenicity) of cholesteryl ester transfer protein, although none clearly resolves the continuing conflict. These new papers are presented against the backdrop of the previous state of knowledge.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.