HDL biology
Serum CETP correlates positively with total cholesterol, beta-lipoprotein, apoB, and apoE, and is lower overall but higher in women, in type 2 diabetes (Med Princ Pract 2007)
Original title: Serum cholesteryl ester transfer protein concentrations are associated with serum levels of total cholesterol, beta-lipoprotein and apoproteins in patients with type 2 diabetes mellitus
Comparing 193 patients with type 2 diabetes mellitus and 68 age-matched healthy controls, serum cholesteryl ester transfer protein (CETP) concentrations, measured by enzyme-linked immunosorbent assay, were lower in diabetic patients than controls (P < 0.01), and female diabetic patients had significantly higher CETP than male patients. Serum CETP correlated positively with total cholesterol and beta-lipoprotein concentrations in diabetic patients (r = 0.485, P = 0.013), and patients with relatively high HDL cholesterol tended to have much lower CETP than those with lower HDL cholesterol. Serum CETP also correlated positively with apolipoprotein B (r = 0.384, P = 0.024) and apolipoprotein E (r = 0.341, P = 0.035).
Original abstract
Objective: To investigate the role of serum cholesterol ester transfer protein (CETP) and the metabolism of various lipids including apoproteins in patients with type 2 diabetes.
Materials And Methods: The relationships between serum concentrations of CETP and various lipids and apoproteins were investigated in 193 patients with type 2 diabetes mellitus and 68 age-matched healthy subjects. Serum CETP concentrations were measured by an enzyme-linked immunosorbent assay.
Results: Serum CETP values were lower in diabetic patients than in healthy controls (p < 0.01). Female diabetic patients had significantly higher CETP concentrations than male patients. Serum CETP concentrations exhibited a significant positive correlation with serum concentrations of cholesterol (TC) and beta-lipoproteins in diabetic patients (r = 0.485, p = 0.013). Patients with relatively high serum concentrations of high-density lipoprotein cholesterol (HDL-C) tended to have much lower CETP concentrations than patients with lower HDL-C concentrations. Serum CETP concentrations showed significant positive correlations with those of apoproteins B (Apo B; r = 0.384, p = 0.024) and E (Apo E; r = 0.341, p = 0.035).
Conclusion: The data indicate that serum CETP is closely involved in the metabolism of TC, beta-lipoprotein, Apo B and Apo E in type 2 diabetic patients.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.