The class
Review surveys the controversial CETP-atherosclerosis relationship and emerging roles in Alzheimer's disease, inflammation and obesity (IUBMB Life 2011)
Original title: Cholesteryl ester transfer protein: the controversial relation to atherosclerosis and emerging new biological roles
This review examines CETP, which has a profound impact on HDL metabolism and consequently on atherosclerosis risk and cardiovascular mortality, surveying the complex and disputed relationship between CETP and atherosclerosis based on experimental, clinical and epidemiological studies. It also discusses recent findings expanding CETP's known functions into new areas of interest, including Alzheimer's disease, inflammation and obesity, positioning CETP as a lipid transfer protein with biological roles extending well beyond classical cardiovascular risk.
Original abstract
Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.