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New tetrazolyl tetrahydroquinoline CETP inhibitors raise HDL cholesterol in a transgenic mouse model (Bioorg Med Chem Lett 2012)
Original title: Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
This letter describes the discovery and structure-activity relationship optimisation of tetrazolyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m, an exemplar from this series, produced a robust increase in HDL cholesterol in a human CETP and human apolipoprotein A-I double transgenic mouse model, alongside favourable pharmacokinetic properties.
Original abstract
This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic properties.
the classmechanismspharmacology
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.