Mechanisms
New diterpenes isolated from Engleromyces goetzii fungus show CETP inhibitory activity (Nat Prod Bioprospect 2015)
Original title: New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity
Researchers isolated three new diterpenes, engleromycenolic acids A and B and engleromycenol, along with three known related compounds (rosololactone, rosenonolactone, and 7-deoxyrosenonolactone), from cultures of the fungus Engleromyces goetzii, which grows naturally on alpine bamboo culms. The structures of the new compounds were elucidated using spectroscopic data. All six compounds were then evaluated for cholesteryl ester transfer protein (CETP) inhibition activity, identifying this fungal diterpene family as a potential natural source of CETP inhibitors.
Original abstract
One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.