The class
Review surveys how current and emerging lipid therapies, including CETP inhibitors, affect lipoprotein(a) levels (Eur Cardiol 2026)
Original title: The Impact of Current and Emerging Therapies on Lipoprotein(a)
This review addresses growing evidence implicating lipoprotein(a) in cardiovascular disease causality, and the interest in whether medical therapies can lower Lp(a) alongside its established role in risk assessment. It notes that statins have been reported to raise Lp(a) levels, while several existing lipid-lowering therapies modestly lower Lp(a), with evidence this contributes to the cardiovascular risk reduction seen with PCSK9 inhibitors. The review also covers emerging therapies that lower Lp(a) either directly, through inhibition of apolipoprotein(a) synthesis or Lp(a) particle formation, or indirectly, in response to treatment with CETP inhibitors, and discusses the implications of these effects for cardiovascular risk.
Original abstract
Increasing evidence has implicated lipoprotein (a) (Lp(a)) in the causality of cardiovascular disease. While measuring Lp(a) has an established role in cardiovascular risk assessment and triaging patients for more intensive risk factor control, there is considerable interest in the ability of medical therapies to lower Lp(a) levels. While statins have been reported to increase Lp(a) levels, a number of existing lipid-lowering interventions have been reported to modestly lower Lp(a) levels, with evidence that this contributes to the reduction in cardiovascular risk observed with proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors. Lp(a) lowering has also been reported with emerging therapies via direct inhibition of apolipoprotein A (Apo A) synthesis or Lp(a) particle formation and indirectly in response to treatment with cholesteryl ester transfer protein (CETP) inhibitors. This article will review the effects of these therapies and implications for cardiovascular risk.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.