Epidemiology 46 items
Cohorts, biobanks and registries in which CETP is the exposure.
Studies
- The EPIC-Norfolk study finds elevated CETP predicts higher future coronary artery disease risk, but only in people with high triglycerides (Circulation 2004)
- CETP activity correlates with LDL-cholesterol but not HDL-cholesterol in 586 healthy Japanese adults (Atherosclerosis 1996)
- CETP rs3764261 genotype modifies the HDL-C lowering effect of a vegetarian diet in 9,263 adults (Taiwan Biobank) (Front Nutr 2026)
- Elevated CETP activity in early pregnancy predicts prediabetes five years later, tracking with monocyte activation (J Clin Endocrinol Metab 2020)
- Large-scale pleiotropy study identifies CETP as one of six newly discovered genome-wide-significant loci for coronary artery disease (J Am Coll Cardiol 2017)
- CETP activity is 30 percent higher in South Asians than Europeans and tracks the full pattern of atherogenic dyslipidemia (Eur J Prev Cardiol 2014)
- In the Framingham Heart Study, low CETP or high PLTP activity predicts more than double the cardiovascular risk in men but not women (Atherosclerosis 2013)
- Framingham study finds plasma CETP activity has only minimal association with blood pressure change over time (J Hypertens 2011)
- Plasma cholesteryl ester transfer activity, not CETP mass, predicts incident cardiovascular disease in a nested case-control study (Atherosclerosis 2011)
- CETP activity is higher in obese adolescent boys and correlates with more TV watching and higher milk intake (Arch Med Res 2011)
- Higher on-statin CETP mass predicts fewer recurrent coronary events in the PROVE IT-TIMI 22 trial (Am J Cardiol 2010)
- Low plasma CETP predicts higher mortality in nondiabetic coronary disease patients in the KAROLA cohort (Eur J Clin Invest 2010)
- Higher circulating CETP activity predicts fewer cardiovascular events over 15 years in the Framingham Heart Study (Circulation 2009)
- Genetically low CETP predicts higher 10-year mortality in statin-treated men with coronary artery disease (Eur Heart J 2008)
- Hepatic lipase and CETP gene variants interact to raise HDL-C, but the combined genotype does not lower cardiovascular risk (J Clin Endocrinol Metab 2007)
- Higher plasma CETP predicts lower cardiovascular event risk specifically in men with low triglycerides, in the PREVEND study (Eur Heart J 2007)
- CETP haplotype linked to higher HDL-C across three populations shows no association with coronary heart disease risk (Hum Genet 2007)
- Higher CETP levels roughly halve vascular disease risk in hemodialysis patients with normal or high HDL cholesterol, odds ratio 0.31 (Am J Kidney Dis 2001)
- In a 24-week RCT, French-press coffee raises CETP activity up to 18% within two weeks, preceding the later rise in LDL cholesterol (J Intern Med 2000)
- CETP activity splits into two distinct subgroups among low-HDL men, with the high-CETP subgroup showing only 30% coronary disease prevalence versus 70% (Arterioscler Thromb Vasc Biol 1995)
- Predicted CETP and LPL cardiovascular risk genotypes are most prevalent in populations with Native American ancestry (Mol Biol Rep 2025)
- In the multi-ethnic MESA cohort, higher HDL cholesterol, HDL particle number, and CETP mass predict lower long-term aortic valve calcification (Arterioscler Thromb Vasc Biol 2022)
- Intensive insulin therapy in newly diagnosed type 1 diabetes progressively suppresses serum CETP and PLTP over the first year (Nutr Metab Cardiovasc Dis 2021)
- The largest cohort study on the topic finds physical activity boosts HDL cholesterol efflux capacity, and shows a U-shaped CETP response in people with diabetes (Eur J Prev Cardiol 2021)
- Urban versus rural residence predicts opposite CETP and PLTP activity patterns in Polish men, independent of smoking and alcohol use (Arch Med Sci 2016)
- CETP concentration is elevated and inversely correlates with hemoglobin in women with iron deficiency anaemia (Clin Lab 2015)
- Common CETP genetic variants do not alter how well the apoB/apoA-I ratio predicts first major cardiovascular events compared with TC/HDL-C (J Clin Lipidol 2012)
- Gastric bypass weight loss in obese women improves HDL remodeling, with CETP mass changes tracking glucose improvement but not fat-mass loss (J Lipid Res 2010)
- Acute Epstein-Barr virus infection transiently elevates CETP activity alongside other atherogenic lipid changes that resolve within four months (Atherosclerosis 2010)
- HIV infection raises CETP mass and activity and redirects cholesterol away from HDL (Atherosclerosis 2007)
- Patients with the highest CETP-driven cholesteryl ester transfer rate had their first heart attack 18 years earlier (J Am Coll Cardiol 2007)
- Adipose tissue CETP mRNA strongly correlates with plasma CETP levels and falls with age in coronary patients (Atherosclerosis 1998)
- CETP EcoNI genotype 2-2 predicts higher rates of coronary disease and neuropathy in type 2 diabetes (Clin Genet 1994)
- CETP activity is 26% lower in alcoholics, detecting 63% of cases at 82% specificity, but insufficient alone as an alcoholism marker (Alcohol Alcohol 1992)
- The EUROASPIRE IV survey finds lower CETP activity in coronary patients with elevated triglycerides and residual apoB-driven risk (Clin Chim Acta 2026)
- Small-quantity lipid-based nutrient supplements do not alter maternal HDL enzyme activity in pregnancy, but CETP and LCAT activity vary by season in Ghana (Curr Dev Nutr 2023)
- Rare CETP coding variants linked to age-related macular degeneration risk in a Japanese population study (Hum Mol Genet 2016)
- CETP is among the genes most strongly linked to lipid change over time and incident hyperlipidemia in a large Chinese cohort study (Circ Cardiovasc Genet 2016)
- Meta-analysis links CETP rs3764261 variant to higher age-related macular degeneration risk across ethnicities (Sci Rep 2015)
- CETP is one of only two loci genome-wide-significantly associated with Lp-PLA2 mass in a five-study CHARGE Consortium meta-analysis (Eur Heart J 2011)
- Dense candidate-gene genotyping confirms CETP among established HDL-C loci in a 7,857-person meta-analysis and reveals multiple independent signals at several loci (Circ Cardiovasc Genet 2011)
- Prospective cohort data link elevated CETP concentration to higher cardiovascular risk only when triglycerides are also high (Curr Opin Lipidol 2004)
- CETP variants rs2033254 and rs12708980 associate with lower intestinal cholesterol absorption markers in a European GWAS (Nutrients 2026)
- Indian patients with high HDL cholesterol are more active, leaner, and at lower cardiovascular risk, with numerically but not significantly lower CETP levels (Ir J Med Sci 2025)
- Low-HDL-cholesterol normolipidemic men show a shift from alpha1 to alpha3 HDL subpopulations, possibly via CETP-driven interconversion (Arterioscler Thromb Vasc Biol 1997)
- CETP TaqIB polymorphism proves noninformative for apo B levels linked to parental heart-attack history (Atherosclerosis 2001)