Inflammation 51 items

Studies

• CETP inhibition is identified as the optimal target for managing dyslipidemia in systemic lupus erythematosus (Int Immunopharmacol 2025)Int Immunopharmacol · April 2025 8
• Landmark hypothesis proposes CETP as an immunological gatekeeper that could be repurposed to treat sepsis (Trends Endocrinol Metab 2020)Trends Endocrinol Metab · February 2020 8
• Human CETP transgenic mice show higher survival and lower IL-6 after polymicrobial sepsis, linked to reduced macrophage TLR4 and NF-kB activation (Mediators Inflamm 2016)Mediators Inflamm · January 2016 8
• Inflammatory macrophages selectively lose the LXR-driven induction of CETP seen in noninflammatory cells, even as ABCA1 and ABCG1 induction persist (Arterioscler Thromb Vasc Biol 2009)Arterioscler Thromb Vasc Biol · August 2009 8
• Mendelian randomization finds genetically proxied CETP inhibition sharply raises the risk of primary Sjögren's syndrome (Curr Pharm Biotechnol 2026)Curr Pharm Biotechnol · January 2026 7
• CETP inhibitors reduce disease severity in experimental colitis by reprogramming macrophages and boosting gut barrier function (J Lipid Res 2025)J Lipid Res · June 2025 7
• Mendelian randomization finds genetically proxied CETP inhibition reduces sepsis-related critical care admission and death (World J Emerg Med 2025)World J Emerg Med · May 2025 7
• CETP expression in bone-marrow-derived immune cells reduces inflammatory features of atherosclerosis, helping explain trial failures (Biomolecules 2023)Biomolecules · October 2023 7
• Genetic evidence suggests the HDL cholesterol-sepsis association is not causally mediated through CETP (Clin Transl Sci 2023)Clin Transl Sci · January 2023 7
• Mendelian randomization finds genetically proxied CETP inhibition, mediated through HDL cholesterol, reduces Crohn's disease risk (Front Immunol 2023)Front Immunol · January 2023 7
• A specific CETP isoform tracks disease severity and may help neutralize bacterial toxin in Gram-negative sepsis (Mol Med 2022)Mol Med · December 2022 7
• Niacin lowers plasma CETP mass 30% by reducing liver macrophage content, not by directly suppressing macrophage CETP expression (Biochem Pharmacol 2012)Biochem Pharmacol · June 2012 7
• Mouse mechanism study: CETP inhibition raises HDL, which blocks IL-1beta activation via SR-B1 and cuts endotoxaemia mortality (J Lipid Res 2025)J Lipid Res · July 2025 6
• Anacetrapib reduces mortality from pneumococcal sepsis in mice by priming monocytes and speeding bacterial clearance (JCI Insight 2024)JCI Insight · April 2024 6
• Combined GIPR/GLP1R agonism additively lowers triglycerides, hepatic steatosis and Kupffer-cell-driven liver inflammation in CETP-humanised NAFLD mice (EBioMedicine 2023)EBioMedicine · June 2023 6
• Time-restricted eating reduces atherosclerotic lesion size and inflammatory cell content in CETP-humanised mice during simulated shift-work (EBioMedicine 2023)EBioMedicine · June 2023 6
• Mendelian randomisation finds genetically proxied CETP inhibitors protect against sepsis, an effect explained largely by ApoA-I (Front Cardiovasc Med 2023)Front Cardiovasc Med · January 2023 6
• In ACCELERATE, a rising hsCRP trajectory over follow-up predicts MACE better than a single baseline reading, even when levels stay under 2 mg/L (Am J Cardiol 2022)Am J Cardiol · August 2022 6
• Unlike three other newly identified EGPA biomarkers, CETP is selectively downregulated and negatively correlates with eosinophil count, aiding diagnosis versus severe asthma (Front Immunol 2022)Front Immunol · January 2022 6
• Elafibranor reduces steatosis, hepatic inflammation and fibrosis progression in CETP-humanised NASH mice, with 87% pathway overlap to human NASH (Sci Rep 2021)Sci Rep · March 2021 6
• CETP inside endothelial cells directly causes oxidative stress and vascular dysfunction, independent of its effect on HDL (Biomolecules 2021)Biomolecules · January 2021 6
• In ACCELERATE, elevated Lp(a) only predicted death, MI and stroke when hsCRP was also 2 mg/L or higher (JAMA Cardiol 2020)JAMA Cardiol · October 2020 6
• Alternating light-dark cycles mimicking shift work roughly double atherosclerotic lesion size and severity in CETP-humanised mice (J Pineal Res 2019)J Pineal Res · October 2019 6
• Four weeks of oral Akkermansia muciniphila lowers cholesterol and reshapes immune cell populations in CETP-humanised mice, but does not reduce cuff-induced neointima formation (Mol Nutr Food Res 2019)Mol Nutr Food Res · August 2019 6
• Bacterial LPS lowers CETP by switching off resting Kupffer cells, an anti-inflammatory response that raises HDL during infection (J Am Heart Assoc 2018)J Am Heart Assoc · March 2018 6
• Higher CETP mass independently predicts a lower leukocyte count, and switching atorvastatin to pitavastatin raises CETP mass by 8.8 percent (Am J Cardiovasc Drugs 2012)Am J Cardiovasc Drugs · October 2012 6
• CETP TaqIB is the only tested genetic system linked to atrial fibrillation, especially when combined with kidney or inflammation markers (BMC Med Genet 2006)BMC Med Genet · April 2006 6
• Endothelial dysfunction develops earlier in male than female CETP-humanised hyperlipidaemic mice, preceding atherosclerosis (Geroscience 2025)Geroscience · April 2025 5
• Tofacitinib raises CETP and atherogenic lipids in rheumatoid arthritis patients naive to prior biologic therapy (J Clin Lipidol 2025)J Clin Lipidol · January 2025 5
• Unlike statins and ezetimibe, CETP inhibitors show only a slight, non-significant rise in CRP across a 53-trial meta-analysis (Cardiovasc Res 2024)Cardiovasc Res · March 2024 5
• CETP and apoA1 levels rise in blood during recovery from COVID-19, opposite to the acute-phase pattern (Sci Rep 2024)Sci Rep · February 2024 5
• CETP-expressing mice heal cutaneous leishmaniasis lesions faster, shifting macrophages toward a healing M2 phenotype (Front Immunol 2024)Front Immunol · January 2024 5
• CETP-overexpressing mice develop worse psoriasis-like skin lesions with higher inflammatory cytokines than normal mice (Lipids Health Dis 2022)Lipids Health Dis · August 2022 5
• In APOE3-Leiden.CETP mice with diet-induced NASH, the oxysterol Oxy210 reduces adipose tissue IL-6, MCP-1 and macrophage markers (Int J Mol Sci 2022)Int J Mol Sci · May 2022 5
• CETP levels track liver enzymes and metabolic markers in psoriasis patients on systemic therapy (Metabolites 2022)Metabolites · April 2022 5
• CETP pushes macrophages toward the M2 phenotype and worsens elastase-induced emphysema in mice, an unexpected lung-disease link (Front Immunol 2021)Front Immunol · January 2021 5
• Diet-induced metabolic syndrome triggers 1396 differentially expressed adipose transcripts, revealing immune and remodeling gene signatures in CETP-humanised mice (Genomics 2020)Genomics · July 2020 5
• CETP variant rs708272 GG genotype cuts the odds of optic neuritis with multiple sclerosis by 62% in a Lithuanian case-control study (Ophthalmic Genet 2019)Ophthalmic Genet · June 2019 5
• High-dose dietary inulin shifts gut bacteria and raises short-chain fatty acids without reducing cholesterol or atherosclerosis in CETP-humanised mice (Sci Rep 2018)Sci Rep · November 2018 5
• CETP promotes exchange of the inflammatory apolipoprotein serum amyloid A between lipoproteins (Arterioscler Thromb Vasc Biol 2018)Arterioscler Thromb Vasc Biol · August 2018 5
• Anacetrapib reproduced the CETP-deficiency phenotype and showed a highly significant, if moderate, coronary benefit in REVEAL, a review on HDL and atherogenic inflammation notes (Atherosclerosis 2018)Atherosclerosis · July 2018 5
• Niacin/laropiprant lowers CETP activity alongside multiple inflammatory markers but modestly improves HDL efflux without changing HDL antioxidant capacity (J Am Heart Assoc 2015)J Am Heart Assoc · September 2015 5
• CETP activity and mass are lower in rheumatoid arthritis patients taking glucocorticoids (J Rheumatol 2013)J Rheumatol · May 2013 5
• The CETP locus reaches genome-wide significance for baseline Lp-PLA2 mass in a JUPITER-trial GWAS of 6,851 statin-treated participants (Circ Cardiovasc Genet 2012)Circ Cardiovasc Genet · November 2012 5
• CETP is one of only two loci genome-wide-significantly associated with Lp-PLA2 mass in a five-study CHARGE Consortium meta-analysis (Eur Heart J 2011)Eur Heart J · October 2011 5
• CETP TaqIB B2 allele more than doubles recurrent event risk in postinfarction patients with high HDL-C and CRP (Arterioscler Thromb Vasc Biol 2010)Arterioscler Thromb Vasc Biol · May 2010 5
• In type 1 diabetic children, arachidonic acid content of LDL cholesteryl ester correlates with CETP activity independent of CETP concentration, suggesting a route to excess LTB4 (Med Hypotheses 2002)Med Hypotheses · November 2002 5
• Tocilizumab decreases CETP activity by ~22% in 16 patients with rheumatoid arthritis (J Clin Lipidol 2026)J Clin Lipidol · August 2026 4
• Review proposes CETP inhibition among potential HDL-directed treatments for sepsis (Int J Mol Sci 2022)Int J Mol Sci · October 2022 4
• Feed efficiency correlates with distinct hepatic gene-expression patterns across diet duration in CETP-humanised mice, per a new dynamic model (Physiol Rep 2021)Physiol Rep · April 2021 4
• A review commits to covering PCSK9, ANGPTL8, sortilin and CETP as candidate molecular links between psoriasis and cardiometabolic syndrome risk (Int J Mol Sci 2020)Int J Mol Sci · May 2020 4