The class
Acute hyperinsulinemia lowers plasma CETP activity in diabetic patients but not in healthy subjects (Metabolism 1994)
Original title: The effect of acute hyperinsulinemia on plasma cholesteryl ester transfer protein activity in patients with non-insulin-dependent diabetes mellitus and healthy subjects
In 11 patients with non-insulin-dependent diabetes mellitus and 10 healthy subjects, insulin infusion significantly reduced plasma CETP activity in the diabetic patients (-37 plus or minus 59 nmol/mL/h, P less than .05) but not in healthy subjects (-7 plus or minus 37 nmol/mL/h), while saline infusion produced no significant change in either group. The change in CETP activity correlated significantly with baseline plasma triglyceride concentration (r=-.523, n=21, P=.01) and marginally with the concurrent triglyceride decrease during hyperinsulinemia (r=.413, n=21, P=.06) across both groups combined, suggesting acute hyperinsulinemia reduces plasma CETP activity specifically in diabetic patients and that CETP and triglyceride metabolism are coordinately regulated by insulin.
Original abstract
The effect of acute hyperinsulinemia on plasma cholesteryl ester (CE) transfer protein (CETP) activity was determined in 11 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 10 healthy subjects. Plasma CETP activity was reduced significantly in NIDDM patients (-37 +/- 59 nmol/mL/h, P < .05) but not in healthy subjects (-7 +/- 37 nmol/mL/h) during insulin infusion. Saline infusion did not alter plasma CETP activity significantly. The change in plasma CETP activity was correlated significantly with the baseline plasma triglyceride (TG) concentration (r = -.523, n = 21, P = .01) and marginally with the concomitant decrease in these levels with acute hyperinsulinemia (r = .413, n = 21, P = .06) in NIDDM patients and healthy subjects combined. These data indicate that acute hyperinsulinemia reduces plasma CETP activity and probably plasma CETP concentration in NIDDM patients, and suggest coordinated regulation of CETP levels and TG metabolism by insulin.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.