Diabetes 130 items

Studies

CETP expression halves atherosclerotic lesion area in non-diabetic LDL-receptor-deficient mice, but this protection disappears with diabetes, another context-dependence finding for the CETP paradox (APMIS 2005)APMIS · January 2005 8
CETP inhibitors reframed: from raising HDL to lowering atherogenic lipoproteins and improving glycaemic control, with obicetrapib the current lead (Circ Res 2026)Circ Res · June 2026 7
Cis-Mendelian randomization finds CETP modification reduces both coronary disease and type 2 diabetes risk (Cardiovasc Diabetol 2026)Cardiovasc Diabetol · May 2026 7
CETP renaissance: a review maps obicetrapib reach beyond LDL-C into dementia, glycaemic control, sepsis and kidney function (Curr Atheroscler Rep 2026)Curr Atheroscler Rep · April 2026 7
Updated meta-analysis of 3,381 patients: obicetrapib cuts LDL-C by 37% and, unexpectedly, new-onset diabetes by 12% (Am J Prev Cardiol 2025)Am J Prev Cardiol · September 2025 7
CETP inhibition as a longevity pathway: apoB lowering, not HDL raising, is the mechanism, with signals in diabetes, dementia and kidney disease (Curr Opin Lipidol 2024)Curr Opin Lipidol · October 2024 7
CETP expression abolishes the atheroprotective effect of large HDL particles in mouse models of type 1 diabetes (Circ Res 2024)Circ Res · June 2024 7
Combining CETP and SGLT2 inhibition genetically improves glycaemic control beyond either alone (Front Endocrinol (Lausanne) 2024)Front Endocrinol (Lausanne) · January 2024 7
Beyond the heart: a review finds no excess macular degeneration risk across over 70,000 CETP-inhibitor trial patients, and surveys links to dementia, diabetes and sepsis (Pharmacol Res 2023)Pharmacol Res · October 2023 7
From raising HDL-C to lowering LDL-C: a review argues Mendelian randomisation and anacetrapib recast the whole CETP-inhibitor class (Cardiovasc Res 2022)Cardiovasc Res · November 2022 7
A genome-wide significant signal near CETP is linked to doubled HDL cholesterol in youth with type 2 diabetes (J Endocr Soc 2021)J Endocr Soc · August 2021 7
dal-OUTCOMES secondary analysis: dalcetrapib cuts new-onset diabetes by 23% after acute coronary syndrome, NNT of 40 (Diabetes Care 2020)Diabetes Care · March 2020 7
In obese CETP-transgenic mice, anacetrapib improved HDL function but drove fatty liver and insulin resistance, a clue to trials where two-thirds of patients were obese (Diabetes 2018)Diabetes · September 2018 7
Meta-analysis finds CETP inhibitor therapy cuts diabetes incidence by 12 percent (Diabetes Metab 2018)Diabetes Metab · February 2018 7
Baseline CETP level predicts how much pitavastatin lowers LDL-C, via LXR-dependent suppression of CETP transcription (Lipids Health Dis 2016)Lipids Health Dis · March 2016 7
Torcetrapib improved glycemic control in 6,661 diabetic ILLUMINATE participants despite the overall harm of the trial (Circulation 2011)Circulation · July 2011 7
Low plasma CETP predicts higher mortality in nondiabetic coronary disease patients in the KAROLA cohort (Eur J Clin Invest 2010)Eur J Clin Invest · May 2010 7
CETP TaqIB B1B1 genotype predicts sudden death in type 2 diabetes, an effect independent of its HDL cholesterol impact (Diabetes Care 2007)Diabetes Care · July 2007 7
Pioglitazone and rosiglitazone move CETP activity in opposite directions despite similar glucose control (Diabetes Metab Res Rev 2007)Diabetes Metab Res Rev · July 2007 7
In the Hoorn Study, high CETP concentration more than triples cardiovascular disease risk in women with Type 2 diabetes, with no such association in men (Diabet Med 2007)Diabet Med · February 2007 7
Streptozotocin-induced diabetes raises CETP mass and activity in transgenic mice, partly reversed by insulin (Can J Physiol Pharmacol 2003)Can J Physiol Pharmacol · October 2003 7
First prospective study finds insulin therapy raises CETP without atherogenic lipid changes (Ann N Y Acad Sci 2001)Ann N Y Acad Sci · December 2001 7
Rising triglycerides redirect CETP-mediated cholesterol transfer from LDL toward VLDL1, fueling small dense LDL in type 2 diabetes (Arterioscler Thromb Vasc Biol 2001)Arterioscler Thromb Vasc Biol · February 2001 7
CETP TaqIB genotype raises HDL-cholesterol and lowers coronary disease only in men with type 2 diabetes (J Clin Endocrinol Metab 1999)J Clin Endocrinol Metab · October 1999 7
CETP, unlike PLTP, rises with hyperlipidemia but stays flat in diabetes, a new ELISA study shows (Arterioscler Thromb Vasc Biol 1999)Arterioscler Thromb Vasc Biol · February 1999 7
CETP and PLTP activity, not diabetes itself, drive elevated cholesteryl ester transfer in NIDDM (Atherosclerosis 1998)Atherosclerosis · September 1998 7
The two faces of CETP inhibitors: a review argues the therapeutic case has shifted from raising HDL-C to lowering apoB, with obicetrapib as proof (Curr Opin Lipidol 2025)Curr Opin Lipidol · October 2025 6
CETP variants show BMI-dependent associations with atherogenic lipids and glucose traits in gestational diabetes (J Matern Fetal Neonatal Med 2024)J Matern Fetal Neonatal Med · October 2024 6
Correcting hyperglycemia does not restore apoC1 inhibition of CETP activity in type 1 diabetes (Metabolites 2024)Metabolites · September 2024 6
Combined GIPR/GLP1R agonism additively lowers triglycerides, hepatic steatosis and Kupffer-cell-driven liver inflammation in CETP-humanised NAFLD mice (EBioMedicine 2023)EBioMedicine · June 2023 6
Updated meta-analysis confirms CETP inhibitors cut new-onset diabetes risk by 16 percent (Eur Heart J Cardiovasc Pharmacother 2022)Eur Heart J Cardiovasc Pharmacother · September 2022 6
In 8,236 diabetes patients from ACCELERATE, evacetrapib raised HDL by 131% and lowered LDL by 32%, yet produced no clinical benefit (BMJ Open Diabetes Res Care 2020)BMJ Open Diabetes Res Care · March 2020 6
CETP promoter variants that raise HDL cholesterol also lower the risk of type 2 diabetes and diabetic kidney disease in Taiwanese adults (Genes 2019)Genes (Basel) · October 2019 6
Neither a liraglutide RCT nor a 1,611-person cohort finds any link between liver fat content and circulating CETP, despite CETP's hepatic Kupffer-cell origin (Sci Rep 2019)Sci Rep · July 2019 6
CETP activity does not track carotid intima-media thickness once diabetes control is poor, unlike in well-controlled patients (Acta Diabetol 2019)Acta Diabetol · April 2019 6
Unlike statins, anacetrapib lowers rather than raises new-onset diabetes risk on top of a coronary benefit, a review argues for a statin-plus-CETP-inhibitor combination (Atherosclerosis 2018)Atherosclerosis · September 2018 6
CETP Taq1B combined with an NOS3 variant multiplies the risk of type 2 diabetes and cardiovascular disease eightfold (Cardiovasc Diabetol 2018)Cardiovasc Diabetol · July 2018 6
Anacetrapib, the new CETP inhibitor: raises large HDL2 and pre-beta HDL, lowers Lp(a) via ApoA production, and shows a hint of glucose benefit (Diseases 2017)Diseases · September 2017 6
Higher serum CETP independently predicted mild cognitive impairment in type 2 diabetic patients (J Alzheimers Dis 2016)J Alzheimers Dis · August 2016 6
Plasma CETP causes pancreatic beta cell dysfunction via islet cholesterol accumulation in mice (Nutr Metab 2016)Nutr Metab (Lond) · January 2016 6
Glycation destroys apolipoprotein C1's natural ability to inhibit CETP in patients with diabetes (Diabetes Care 2014)Diabetes Care · February 2014 6
Torcetrapib cuts insulin levels by 49 percent and improves glucose uptake across tissues in insulin-resistant hamsters (Atherosclerosis 2014)Atherosclerosis · January 2014 6
CETP inhibition boosts postprandial insulin secretion via enhanced cholesterol efflux from beta cells (Circ Res 2013)Circ Res · May 2013 6
CETP transgene protects obese female mice from insulin resistance via bile acid signalling (Mol Metab 2013)Mol Metab · January 2013 6
CETP B1 allele combined with an eNOS variant raises coronary artery disease risk 18-fold in Western Iranians (Hum Genomics 2012)Hum Genomics · September 2012 6
Non-HDL-C and insulin resistance predict high CETP activity in patients at risk for type 2 diabetes (Clin Biochem 2012)Clin Biochem · February 2012 6
Low CETP activity more than doubles coronary artery disease risk in an Asian Indian diabetic cohort (Pharmacogenet Genomics 2012)Pharmacogenet Genomics · February 2012 6
Ezetimibe lowers CETP mass by 20 percent in most type 2 diabetes patients, tracking with HDL subclass shifts (Endocr J 2012)Endocr J · January 2012 6
Torcetrapib boosts reverse cholesterol transport by 118 percent in obese, insulin-resistant transgenic mice (Clin Transl Sci 2011)Clin Transl Sci · December 2011 6
CETP enhances insulin-stimulated glucose uptake in human adipocyte cells (Life Sci 2011)Life Sci · July 2011 6
A four-week rimonabant intervention in CETP-humanised mice cuts body weight 9.4% and plasma cholesterol 24%, with systems-lipidomics revealing distinct plasma and liver lipid signatures (PLoS One 2011)PLoS One · January 2011 6
CETP Taq1B B1B1 genotype independently raises type 2 diabetes risk, and a hepatic lipase variant amplifies it further (PLoS One 2011)PLoS One · January 2011 6
CETP promoter variant -629C>A is strongly linked to cardiovascular disease specifically in Asian Indian patients with type 2 diabetes (J Diabetes Complications 2011)J Diabetes Complications · December 2010 6
CETP TaqIB B2 allele partly protects against the atherogenic HDL profile of type 2 diabetes, but only in women with milder insulin resistance (Atherosclerosis 2010)Atherosclerosis · November 2009 6
CETP Taq1B B1B1 genotype is linked to higher insulin and HOMA levels, suggesting a role in glucose regulation (Nutr Metab Cardiovasc Dis 2011)Nutr Metab Cardiovasc Dis · October 2009 6
Plasma cholesteryl ester transfer, driven by CETP and triglycerides, predicts carotid intima-media thickness in type 2 diabetes (Diabetes 2005)Diabetes · December 2005 6
CETP TaqI B1B2 genotype triples hypertension risk in North Indian diabetics despite no direct T2DM link (BMC Endocr Disord 2005)BMC Endocr Disord · July 2005 6
Type 2 diabetes eliminates the CETP elevation normally seen in obesity by suppressing hepatic CETP expression (J Clin Endocrinol Metab 2005)J Clin Endocrinol Metab · January 2005 6
A low-fat, low-cholesterol diet lowers CETP activity in type 1 diabetics without harming cholesterol efflux (Scand J Clin Lab Invest 2005)Scand J Clin Lab Invest · January 2005 6
Review names CETP-driven triglyceride enrichment of HDL as a key mechanism of low HDL in insulin resistance (Clin Biochem 2003)Clin Biochem · September 2003 6
Insulin down-regulates CETP gene expression, reversing the elevation seen with insulin deficiency in transgenic mice (J Lipid Res 2003)J Lipid Res · July 2003 6
Adding CETP shifts lipoproteins toward VLDL and IDL/LDL, and appears to blunt diabetes-driven hyperlipidemia in LPL-deficient mice (J Lipid Res 2002)J Lipid Res · June 2002 6
CETP TaqIB B1B1 genotype independently predicts coronary disease, arteriosclerosis, and stroke in Japanese type 2 diabetics (Diabetes 2002)Diabetes · March 2002 6
Clamp-induced suppression of CETP activity is unrelated to whole-body insulin sensitivity, exercise-training study finds (Metabolism 2001)Metabolism · July 2001 6
CETP concentration and transfer activity are normal in well-matched type 1 diabetics, contradicting earlier reports (Eur J Intern Med 2000)Eur J Intern Med · October 2000 6
Improving glycemic control lowers postprandial CETP activity and chylomicron particle numbers in type 2 diabetes (Atherosclerosis 2000)Atherosclerosis · February 2000 6
CETP accounts for 5% of small dense LDL variability in Chinese diabetic patients despite unchanged CETP activity (Atherosclerosis 1999)Atherosclerosis · August 1999 6
CETP TaqIB genotype predicts opposite lipid responses to a cholesterol-lowering diet in type 1 diabetics (Diabetes 1997)Diabetes · December 1997 6
CETP activity is lower in diabetic men without coronary disease than in disease-free non-diabetic men (Metabolism 1994)Metabolism · December 1994 6
Acute hyperinsulinemia lowers plasma CETP activity in diabetic patients but not in healthy subjects (Metabolism 1994)Metabolism · November 1994 6
Intraperitoneal insulin delivery raises CETP activity 25 percent independent of glucose control in type 1 diabetes (Metabolism 1994)Metabolism · June 1994 6
Reduced CETP activity accompanies an atherogenic small dense LDL profile in long-standing type 1 diabetes (Front Endocrinol 2026)Front Endocrinol (Lausanne) · January 2026 5
CETP rs708272 GG genotype blunts the benefit of a dietary intervention when trans fatty acid intake is high, secondary analysis finds (Nutrients 2024)Nutrients · October 2024 5
The CETP rs708272 G/G genotype is significantly linked to dyslipidemia in Chinese patients with diabetes (World J Clin Cases 2024)World J Clin Cases · July 2024 5
Dietary acid load interacts with CETP TaqB1 genotype to worsen lipid profile in B1B1 carriers with type 2 diabetes (BMC Endocr Disord 2023)BMC Endocr Disord · July 2023 5
Mendelian randomization finds HDL cholesterol protective against diabetic retinopathy, but genetically proxied CETP inhibition shows no effect (Atherosclerosis 2023)Atherosclerosis · February 2023 5
Review notes that impaired apoC1 inhibition of CETP in diabetes may explain elevated CETP activity in diabetic patients (Cardiovasc Diabetol 2022)Cardiovasc Diabetol · December 2022 5
The CETP TaqIB polymorphism interacts with diet quality to shape metabolic markers in type 2 diabetes (J Hum Nutr Diet 2022)J Hum Nutr Diet · December 2021 5
CETP TaqB1 polymorphism interacts with dietary insulin index to shape cardiovascular risk in type 2 diabetes (Sci Rep 2021)Sci Rep · August 2021 5
CETP TaqIB genotype shapes how plant oils affect metabolic markers in people with diabetes (J Cardiovasc Thorac Res 2020)J Cardiovasc Thorac Res · January 2020 5
In the ACCELERATE diabetes cohort, higher baseline HbA1c independently predicted cardiovascular events despite statin therapy (J Am Heart Assoc 2020)J Am Heart Assoc · December 2019 5
CETP TaqIB genotype shapes HDL cholesterol but not diabetes risk in Southern Thai adults (Arch Med Res 2018)Arch Med Res · October 2018 5
For lipid management in diabetes, CETP inhibitor trials have generally underwhelmed and are no longer being developed, a review concludes (Diabet Med 2018)Diabet Med · May 2018 5
Six-month high-fat feeding of CETP-humanised male mice reveals a biphasic lipid response with insulin resistance preceding dyslipidemia, mirroring human ageing (Physiol Rep 2017)Physiol Rep · October 2017 5
Basal-bolus insulin lowers maternal triglycerides in gestational diabetes without changing CETP activity (J Obstet Gynaecol Res 2017)J Obstet Gynaecol Res · July 2017 5
Total fat intake modifies the CETP Taq1B link to HDL cholesterol only in type 2 diabetes patients without dyslipidemia (Clin Nutr 2018)Clin Nutr · December 2016 5
CETP Taq1B is linked to glycated hemoglobin levels in hyperlipidemic patients with diabetes, a link modulated by an LIPG variant (Can J Diabetes 2016)Can J Diabetes · August 2016 5
Plasma CETP is higher in metabolic syndrome, but the Taq1B genotype itself shows no direct link to the syndrome in Iranian subjects (Biochem Genet 2016)Biochem Genet · August 2016 5
CETP variant rs3764261 raises HDL cholesterol but does not affect diabetes risk or recurrent cardiovascular events in vascular disease patients (Atherosclerosis 2015)Atherosclerosis · August 2015 5
CETP TaqIB B2 allele carriers have higher HDL cholesterol and antioxidant enzyme activity in both healthy and diabetic Argentinians (J Diabetes Investig 2015)J Diabetes Investig · July 2014 5
Low-normal thyroid function raises plasma cholesteryl ester transfer in type 2 diabetes (Atherosclerosis 2013)Atherosclerosis · April 2013 5
Dalcetrapib cut CETP activity up to 58% and raised HDL-C up to 34% regardless of diabetes or metabolic syndrome status (Diabetes Obes Metab 2012)Diabetes Obes Metab · November 2011 5
Statin-induced LDL and non-HDL cholesterol reductions track with falling CETP mass in type 2 diabetes (Expert Opin Ther Targets 2009)Expert Opin Ther Targets · July 2009 5
Review dissects how CETP and PLTP jointly drive low HDL in type 2 diabetes via specific apolipoprotein modulators (Curr Opin Lipidol 2007)Curr Opin Lipidol · June 2007 5
CETP B1B1 genotype triples coronary artery disease risk in Taiwanese patients with type 2 diabetes (Metabolism 2007)Metabolism · June 2007 5
CETP activity rises with the number of diseased coronary vessels in Tunisian type 2 diabetics (Clin Biochem 2005)Clin Biochem · April 2005 5
CETP B2B2 genotype is more common in diabetics but less common after a heart attack, suggesting a role in identifying diabetic risk (Atherosclerosis 2005)Atherosclerosis · January 2005 5
Review proposes CETP-driven cholesteryl ester transfer as the metabolic link between high triglycerides and low HDL cholesterol in insulin resistance (Eur J Clin Invest 2003)Eur J Clin Invest · December 2003 5
In type 1 diabetic children, arachidonic acid content of LDL cholesteryl ester correlates with CETP activity independent of CETP concentration, suggesting a route to excess LTB4 (Med Hypotheses 2002)Med Hypotheses · November 2002 5
AICAR lowers blood glucose and insulin by suppressing endogenous glucose production, without correcting dyslipidaemia, in diabetic CETP-expressing KKAy mice (Diabetologia 2001)Diabetologia · December 2001 5
CETP TaqIB genotype linked to macroangiopathy risk in Japanese patients with type 2 diabetes (Atherosclerosis 2001)Atherosclerosis · May 2001 5
CETP TaqIB genotype shows no link to diabetic kidney disease severity in a large type 1 diabetes cohort (Nephrol Dial Transplant 2000)Nephrol Dial Transplant · December 2000 5
CETP rises over time regardless of whether progestogen is added to low-dose estradiol in diabetic women (Diabet Med 2000)Diabet Med · April 2000 5
A new sandwich ELISA measures plasma CETP concentration with under 10% assay variability (Clin Biochem 1999)Clin Biochem · June 1999 5
CETP-driven cholesterol enrichment of remnant particles worsens atherosclerosis risk in diabetic dyslipidaemia (Eur Heart J 1998)Eur Heart J · July 1998 5
CETP B2 allele raises HDL cholesterol in diabetic men, but moderate alcohol intake shows no benefit unlike in non-diabetics (Scand J Clin Lab Invest 1998)Scand J Clin Lab Invest · May 1998 5
CETP activity stays normal and unchanged with insulin lispro or regular insulin in type 1 diabetes (Metabolism 1998)Metabolism · April 1998 5
CETP Taq1B genotype predicts HDL cholesterol in diabetic patients independent of measured CETP concentration (J Lipid Res 1998)J Lipid Res · January 1998 5
Intraperitoneal insulin normalizes elevated cholesteryl ester transfer in NIDDM, but injections alone do not (Diabetes 1997)Diabetes · March 1997 5
Net cholesteryl ester transfer roughly doubles in NIDDM even though CETP activity itself is unchanged (Atherosclerosis 1996)Atherosclerosis · June 1996 5
Diabetic cynomolgus monkeys show accelerated cholesteryl ester transfer, mirroring human diabetic dyslipidaemia (J Lipid Res 1995)J Lipid Res · April 1995 5
CETP and LCAT activity rise postprandially in NIDDM, but neither differs from controls at baseline (Atherosclerosis 1995)Atherosclerosis · March 1995 5
Recombination experiments trace accelerated cholesteryl ester transfer in IDDM to a CETP-containing plasma fraction (Eur J Clin Invest 1994)Eur J Clin Invest · September 1994 5
Recombination experiments trace accelerated cholesteryl ester transfer in NIDDM to the VLDL plus LDL fraction (Atherosclerosis 1993)Atherosclerosis · December 1993 5
CETP variant rs708272 emerges as a candidate screening marker for type 2 diabetes risk in Filipinos, genomic study finds (PLoS One 2024)PLoS One · January 2024 4
Review links HDL dysfunction in type 2 diabetes to impaired glycaemic control and highlights CETP inhibitors as a candidate therapy (Curr Med Chem 2024)Curr Med Chem · January 2024 4
CETP concentration does not differ between peripheral artery disease patients with or without type 2 diabetes (Vasc Med 2021)Vasc Med · June 2021 4
In ACCELERATE, higher baseline fasting insulin independently predicted MACE and future revascularisation in diabetes patients (Diab Vasc Dis Res 2019)Diab Vasc Dis Res · March 2019 4
CETP inhibitors do not appear to raise new-onset diabetes risk unlike LDL-receptor-acting drugs (J Cardiovasc Pharmacol Ther 2018)J Cardiovasc Pharmacol Ther · February 2018 4
CETP TaqIB variant is linked to diabetic retinopathy incidence over nine years, though HbA1c and triglycerides prove the stronger predictors (Diabetes Res Clin Pract 2017)Diabetes Res Clin Pract · July 2017 4
Pioglitazone does not change CETP or improve peripheral vessel function in nondiabetic patients over nine months (Cardiology 2015)Cardiology · January 2015 4
Review highlights that CETP inhibitors lower blood glucose alongside raising HDL cholesterol (Front Pharmacol 2015)Front Pharmacol · January 2015 4
CETP-driven cholesteryl ester enrichment of apoB particles is exaggerated in type 1 diabetes (Eur J Clin Invest 2012)Eur J Clin Invest · January 2012 4
Omega-3 fatty acid intake correlates with lower CETP activity in Tunisian women with type 2 diabetes (Nutr Metab Cardiovasc Dis 2006)Nutr Metab Cardiovasc Dis · October 2005 4
CETP Taq1B B2B2 genotype linked to low HDL cholesterol in Turkish type 2 diabetic patients (Int J Mol Med 2004)Int J Mol Med · June 2004 4
Review explains how CETP-mediated cholesteryl ester transfer links low HDL-C to high triglycerides in insulin resistance and type 2 diabetes (Clin Lab 2003)Clin Lab · January 2003 4
Review argues the role of CETP and reverse cholesterol transport defects in diabetic atherosclerosis remains unproven, despite altered HDL composition (Diabetes Metab Res Rev 2000)Diabetes Metab Res Rev · January 2000 4
Walnut kernel polyphenols are proposed to improve metabolic syndrome partly by inhibiting SREBPs, PCSK9 and CETP (Food Sci Nutr 2024)Food Sci Nutr · January 2024 3
A diabetes-dyslipidemia review predicts the disappointing torcetrapib results will renew interest in niacin therapy (Curr Opin Endocrinol Diabetes Obes 2008)Curr Opin Endocrinol Diabetes Obes · April 2008 3
CETP mass and cholesteryl ester transfer are unchanged in normotriglyceridemic type II diabetics, fasting or fed (Atherosclerosis 1996)Atherosclerosis · November 1996 3