Genetics
Review surveys the biochemistry and molecular basis of CETP deficiency disorders (J Atheroscler Thromb 1996)
Original title: Molecular disorders of cholesteryl ester transfer protein
This review covers plasma CETP, a key protein in reverse cholesterol transport that facilitates cholesteryl ester transfer from HDL to apolipoprotein B-containing lipoproteins. It traces how the discovery of CETP-deficient subjects with marked hyper-HDL-cholesterolemia highlighted the importance of this protein in lipoprotein metabolism, noting that CETP deficiency causes various abnormalities in the concentration, composition, and function of both HDL and LDL. The review focuses on recent knowledge of the biochemical and molecular biological aspects of CETP, with detailed coverage of the lipoprotein abnormalities and molecular basis underlying CETP deficiency.
Original abstract
Plasma cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl ester (CE) from HDL to apolipoprotein B-containing lipoproteins and therefore is a key protein in the reverse cholesterol transport system. The importance of plasma CETP in lipoprotein metabolism has been highlighted by the discovery of CETP-deficient subjects with a marked hyper-HDL-cholesterolemia. The deficiency of CETP causes various abnormalities in the concentration, composition, and functions of high density and low density lipoproteins. The current review will focus on some of the recent knowledge on CETP with special reference to the biochemical and molecular biological aspects of CETP. Furthermore, detailed information will be presented regarding the lipoprotein abnormalities and molecular basis of CETP deficiency.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.