Genetics 737 items
CETP variants, inherited deficiency and the Mendelian randomisation that reframed the class.
Trials, agents, guidance
- Trial DalCor genotype-defined trial (NCT05918861)
- Trial dal-GenE
- Agent Dalcetrapib
Studies
- Genetically lower CETP activity reduces dementia risk in a 1,091,775-person Mendelian randomization meta-analysis (Alzheimers Dement 2025)
- A 34-year genetic study finds CETP-lowering variants cut ischemic heart disease risk by 24 percent with no adverse effects seen with torcetrapib (J Am Coll Cardiol 2012)
- Mendelian randomization shows the hypertensive effect of torcetrapib is not caused by CETP inhibition (Circulation 2010)
- Landmark study links large HDL and LDL particle size and the CETP 405 valine allele to exceptional human longevity (JAMA 2003)
- The human CETP gene is cloned and sequenced for the first time (Nature 1987)
- dal-GenE: dalcetrapib misses its primary endpoint in ADCY9 AA-genotype patients (HR 0.88), even after a genetically pre-selected retest of dal-OUTCOMES (Eur Heart J 2022)
- Genetic CETP deficiency, mimicking a lifetime of CETP inhibition, trades a lower cardiovascular death and MI risk for a matching rise in AMD (JAMA Cardiol 2022)
- Landmark genetic study explains why CETP inhibitors lower LDL cholesterol without reducing cardiovascular events (JAMA 2017)
- Discovery study links the ADCY9 rs1967309 polymorphism to a 39% cardiovascular benefit from dalcetrapib (Circ Cardiovasc Genet 2015)
- Landmark JAMA meta-analysis of over 190,000 people finds CETP genotypes that inhibit CETP activity only weakly reduce coronary risk (JAMA 2008)
- The CETP 405-valine allele is identified as the first genotype linked to inherited exceptional human longevity (Mech Ageing Dev 2005)
- Duff Memorial Lecture synthesizes how CETP and PLTP knockouts revealed the liver pathways governing HDL catabolism (Arterioscler Thromb Vasc Biol 2000)
- Landmark REGRESS trial finds the CETP B1B1 genotype predicts who benefits from pravastatin against coronary atherosclerosis progression (N Engl J Med 1998)
- Annual Review synthesizes CETP structure, the reverse cholesterol transport hypothesis, and the SREBP-driven regulation of the CETP gene (Annu Rev Nutr 1998)
- Landmark Omagari study first shows CETP-deficiency-driven high HDL cholesterol is not a longevity syndrome (Arterioscler Thromb Vasc Biol 1997)
- Landmark Honolulu Heart Program study first shows CETP gene mutations raise coronary heart disease risk despite raising HDL cholesterol (J Clin Invest 1996)
- Landmark ECTIM study is the first to show alcohol intake determines whether the CETP B2 allele protects against heart attack (J Clin Invest 1995)
- CETP deficiency from two prevalent mutations is identified as the first common genetic cause of high HDL cholesterol in the general population (J Clin Invest 1994)
- The original discovery of CETP mutation D442G reveals a dominant-negative multimeric mechanism causing threefold HDL elevation in heterozygotes (J Clin Invest 1993)
- Landmark Nature paper shows CETP-expressing transgenic mice develop far worse atherosclerosis than non-expressing controls (Nature 1993)
- A common CETP gene splicing mutation causes markedly elevated HDL in Japan without excess atherosclerosis (N Engl J Med 1990)
- The original discovery of the intron 14 splice-site mutation identifies the molecular cause of CETP deficiency in four Japanese families (Biochem Biophys Res Commun 1990)
- Two Japanese siblings with markedly increased HDL are found homozygous for a CETP intron-14 splice-site mutation eliminating the protein (Nature 1989)
- The human CETP gene is first mapped to chromosome 16q12-21 using somatic cell hybrids and in situ hybridization (Genomics 1987)
- REVEAL, the largest ADCY9 pharmacogenetic study yet, finds no genotype interaction with the benefit of anacetrapib, unlike the dalcetrapib hypothesis (Circulation 2019)
- Large Copenhagen study shows CETP-mutation-driven HDL elevation actually raises heart disease risk in women, not lowers it (Circulation 2000)
- A novel transposon-based method sequences 5kb of CETP's 5' regulatory region, revealing a 5.7kb fragment drives far stronger transcription than the minimal promoter (Gene 1997)
- Drug-target Mendelian randomization finds lower CETP concentration cuts Lewy body and Parkinson's dementia risk, especially in APOE-e4 carriers (Alzheimers Res Ther 2024)
- A 425,354-person UK Biobank Mendelian randomization study finds genetically lower CETP cuts coronary artery disease risk with additive benefit alongside PCSK9 (JAMA Cardiol 2022)
- Drug-target Mendelian randomization confirms CETP as an effective target for coronary heart disease with an on-target macular degeneration risk (Nat Commun 2021)
- 13,677-subject meta-analysis confirms CETP TaqIB drives HDL and CAD risk but does not affect pravastatin response (Circulation 2005)
- CETP protein-truncating variants cut coronary artery disease risk even in Japanese patients with severe familial hypercholesterolemia (Atherosclerosis 2025)
- CETP inhibition is identified as the optimal target for managing dyslipidemia in systemic lupus erythematosus (Int Immunopharmacol 2025)
- Drug-target Mendelian randomization finds genetically proxied CETP inhibition protects against subarachnoid hemorrhage with no safety signal (Eur Stroke J 2025)
- Mendelian randomization finds CETP inhibition uniquely associated with increased breast cancer risk among lipid-lowering drug targets (Cancer Causes Control 2024)
- A genome-wide association study identifies protective CETP gene variants underlying cardiovascular resilience in older adults (J Am Heart Assoc 2023)
- ADCY9 and CETP show signs of having coevolved under sex-specific selection, offering a biological explanation for the pharmacogenomic signal of dalcetrapib (eLife 2021)
- Large Chinese biobank study finds genetically lower CETP activity raises HDL cholesterol but not vascular protection (JAMA Cardiol 2018)
- Protein-truncating CETP variants lower coronary heart disease risk by 30 percent in a 58 469-participant sequencing study (Circ Res 2017)
- CETP variants that raise HDL cholesterol also increase risk of intracerebral haemorrhage (Ann Neurol 2016)
- Genotype-dependent dalcetrapib effects on cholesterol efflux and inflammation confirm the ADCY9 pharmacogenomic signal (Circ Cardiovasc Genet 2016)
- CETP binds factor Xa and boosts prothrombinase activity, and the VTE-linked Gln451 variant shows five-fold higher thrombin generation than wild-type (J Atheroscler Thromb 2016)
- Two CETP splice-affecting variants raise mortality and heart attack risk specifically in men, mechanism traced to liver mRNA splicing (PLoS One 2012)
- Genome-wide analysis of 18,245 women finds CETP is the only HDL-raising locus that also lowers heart attack risk, supporting a causal role (Circ Cardiovasc Genet 2009)
- CETP coding variants R451Q and A373P predict coronary calcium independent of HDL cholesterol in a multi-ethnic cohort (Atherosclerosis 2008)
- Genome-wide meta-analysis of 20,000-plus people confirms CETP among eleven established lipid loci and finds new ones (Nat Genet 2008)
- A CETP variant that raises HDL cholesterol paradoxically raises coronary risk once HDL-cholesterol is accounted for, large PREVEND study finds (J Clin Endocrinol Metab 2006)
- CETP Taq1B B2B2 genotype predicts higher cardiovascular risk despite equal statin response in familial hypercholesterolemia (Eur J Hum Genet 2005)
- CETP TaqIB genotype fails to predict cardiovascular events or pravastatin benefit in the CARE trial cohort (J Am Coll Cardiol 2004)
- Human CETP expression completely prevents diet-induced atherosclerotic lesions in diabetic obese db/db mice (Arterioscler Thromb Vasc Biol 2003)
- CETP -629A allele cuts cardiovascular mortality risk in half in coronary artery disease patients, independent of HDL cholesterol or CETP activity (J Am Coll Cardiol 2003)
- Combined CETP gene polymorphisms explain up to 10 percent of the variation in carotid intima-media thickness (Eur J Clin Invest 2001)
- CETP mutations that lower HDL cholesterol paradoxically cut ischemic heart disease risk 36% in women, Copenhagen City Heart Study finds (Circulation 2000)
- CETP TaqIB B2 allele lowers CHD risk in men in the Framingham Offspring Study (Arterioscler Thromb Vasc Biol 2000)
- ApoE or LDL receptor knockout raises hepatic CETP transgene expression eightfold, revealing a cholesterol-sensing mechanism independent of both (J Clin Invest 1996)
- CETP-deficient humans clear LDL apoB faster, explaining their low LDL despite reduced apoB production (J Clin Invest 1995)
- ApoB/CETP double transgenic mice recreate a human-like lipoprotein cholesterol distribution on chow diet (J Lipid Res 1995)
- CETP expression suppresses hepatic LDL receptor mRNA dose-dependently, explaining apoB-lipoprotein accumulation (J Biol Chem 1993)
- Stable-isotope kinetics show CETP deficiency raises HDL by slowing apoA-I and apoA-II catabolism, not by increasing production (J Clin Invest 1993)
- CETP deficiency dose-dependently raises HDL2 cholesterol up to sixfold in homozygotes and twofold in heterozygotes (Metabolism 1991)
- First human CETP transgenic mice show that active plasma CETP causally reduces HDL cholesterol (J Biol Chem 1991)
- A twin study introduces the CETP locus as a variability gene that shapes the spread, not the average, of cholesterol levels (Clin Genet 1989)
- Cis-Mendelian randomization finds CETP modification reduces both coronary disease and type 2 diabetes risk (Cardiovasc Diabetol 2026)
- CETP rs3764261 genotype modifies the HDL-C lowering effect of a vegetarian diet in 9,263 adults (Taiwan Biobank) (Front Nutr 2026)
- Mendelian randomization finds genetically proxied CETP inhibition sharply raises the risk of primary Sjögren's syndrome (Curr Pharm Biotechnol 2026)
- dal-GenE: the MI benefit of dalcetrapib in ADCY9 AA-genotype patients survives adjustment for an 18-variable risk prediction index (Eur J Prev Cardiol 2025)
- Mendelian randomization finds genetically proxied CETP inhibition reduces sepsis-related critical care admission and death (World J Emerg Med 2025)
- Two CETP gene variants independently predict worse outcomes after ischemic stroke, alongside HMGCR and PCSK9 variants (J Am Heart Assoc 2024)
- Mendelian randomisation across ancestries: CETP inhibition should protect against cardiovascular disease equally in East Asian and European populations (Nat Commun 2024)
- Combining CETP and SGLT2 inhibition genetically improves glycaemic control beyond either alone (Front Endocrinol (Lausanne) 2024)
- Drug-target Mendelian randomization links genetically lower CETP to longer human lifespan (Aging 2023)
- A Polynesian-specific CETP missense variant lowers CETP activity by 27.9% and improves the lipid profile (HGG Adv 2023)
- Serum amyloid A is required for CETP to promote atherosclerosis in mice, suggesting CETP inhibition may help patients with high inflammation (J Lipid Res 2023)
- Genetic evidence suggests the HDL cholesterol-sepsis association is not causally mediated through CETP (Clin Transl Sci 2023)
- Mendelian randomization finds genetically proxied CETP inhibition, mediated through HDL cholesterol, reduces Crohn's disease risk (Front Immunol 2023)
- From raising HDL-C to lowering LDL-C: a review argues Mendelian randomisation and anacetrapib recast the whole CETP-inhibitor class (Cardiovasc Res 2022)
- Drug-target Mendelian randomization finds CETP and other lipid drug targets have distinct metabolomic signatures despite similar CAD benefit (PLoS Biol 2022)
- A genome-wide significant signal near CETP is linked to doubled HDL cholesterol in youth with type 2 diabetes (J Endocr Soc 2021)
- How ADCY9 and CETP might interact inside arterial macrophages to explain the genotype-dependent effect of dalcetrapib, with dal-GenE poised to test it (Circ Genom Precis Med 2021)
- Genetic and drug-based CETP inhibition preserves HDL and improves survival in sepsis, in humans and humanized mice (Circulation 2021)
- Mendelian randomisation links genetically raised HDL and LDL cholesterol, including a CETP locus signal, to higher breast cancer risk (PLoS Med 2020)
- Genetic variants at the CETP inhibitor target show split effects on ischaemic small vessel stroke and brain haemorrhage (Brain 2020)
- Genetic CETP inhibition doesn't touch particle-size-defined LDL-C the way statins do, but lowers remnant, VLDL and HDL-triglyceride content instead (PLoS Biol 2019)
- A rare CETP variant lowers HDL cholesterol and predicts worse survival in sepsis, with Mendelian randomization suggesting causation (Am J Respir Crit Care Med 2019)
- Mendelian randomisation upends the textbook story: the causal effects of CETP fall mainly on large HDL and small VLDL, not LDL, hinting anacetrapib works by cutting VLDL (Eur J Hum Genet 2019)
- First genome-wide association study identifies genetic determinants of circulating CETP concentration (Circ Genom Precis Med 2018)
- ACCELERATE nested case-control study finds no significant ADCY9 genotype interaction with evacetrapib, unlike the dalcetrapib signal (JAMA Cardiol 2018)
- Mendelian randomisation links the CETP inhibitor target locus to lower abdominal aortic aneurysm risk (JAMA Cardiol 2018)
- Large-scale pleiotropy study identifies CETP as one of six newly discovered genome-wide-significant loci for coronary artery disease (J Am Coll Cardiol 2017)
- Pharmacogenomics review details how ADCY9 genotype determines the cardiovascular effect of dalcetrapib in dal-OUTCOMES (ATVB 2017)
- Yamashita argues CETP inhibition may backfire by generating small dense LDL and downregulating hepatic SR-BI (Curr Opin Lipidol 2016)
- The CETP locus is the only genome-wide-significant genetic determinant of HDL-C response to statins, independent of baseline HDL-C, in a 27,720-person meta-analysis (J Med Genet 2016)
- Mendelian randomization meta-analysis of 40,000 subjects finds lower circulating CETP causally reduces coronary heart disease risk (Circ Cardiovasc Genet 2015)
- CETP -629C/A genotype predicts HDL-C but the CC genotype benefits most from atorvastatin's LDL-C-lowering effect in Chinese CHD patients (Med Sci Monit 2014)
- CETP genotype predicts who benefits most from a low-carbohydrate diet for raising HDL and lowering triglycerides, replicated across two randomized trials (J Lipid Res 2015)
- Mendelian randomization using the CETP TaqIB polymorphism finds genetically raised HDL cholesterol does not translate into lower coronary disease risk (BMC Med Genet 2014)
- Provocative 2014 opinion piece argues the evidence had turned against CETP inhibition and calls for an urgent trial review (F1000Res 2014)
- CETP enhancer variant rs3764261 boosts statin-associated HDL-C rise but reduces statin protection against myocardial infarction (Clin Pharmacol Ther 2013)
- CETP I405V reverses direction: protective for longevity in Ashkenazi Jews but a risk allele in Chinese (PLoS One 2013)
- Two linked CETP SNPs more than double the odds of fatty liver in adolescent girls, independent of adiposity (J Gastroenterol Hepatol 2012)
- CETP R451Q raises coronary stenosis risk while Taq1B B2 lowers it in a Tunisian angiography cohort (J Cardiovasc Med (Hagerstown) 2012)
- CETP and ABCA1 genotype together determine whether atorvastatin or simvastatin gives a better lipid response (Angiology 2012)
- Heterozygous CETP-deficient HDL is remodeled toward more cholesteryl ester and less triglyceride but keeps normal antioxidative capacity (PLoS One 2012)
- CETP deficiency, not high CETP activity, impairs postprandial lipemia clearance and correlates with carotid atherosclerosis in women (Lipids Health Dis 2011)
- CETP variant rs1532624 reduces heart attack risk in women regardless of physical activity level, unlike an LPL variant with an activity-dependent effect (Circ Cardiovasc Genet 2011)
- CETP TaqI and -629C/A variants predict a bigger HDL-C rise on atorvastatin, while CETP 405I/V predicts higher MI risk in CAD patients (DNA Cell Biol 2010)
- People with genetically reduced CETP levels have lower, not higher, blood pressure, arguing against a CETP class effect behind the hypertension seen with torcetrapib (Mayo Clin Proc 2010)
- CETP Taq1B B2 allele linked to lower coronary artery disease risk in Asian Indians (J Community Genet 2010)
- A JAMA study links CETP valine-405 homozygosity to slower memory decline and lower dementia incidence (JAMA 2010)
- CETP gene mutations shape LDL and HDL cholesterol from birth through the first year of life (Clin Chim Acta 2009)
- CETP TaqIB B2 allele linked to higher HDL cholesterol in Greek children (Nutr Metab Cardiovasc Dis 2010)
- A novel CETP R37X mutation causes complete CETP deficiency and extreme HDL elevation without atherosclerosis in a Swedish man (Atherosclerosis 2009)
- CETP variants without known cardioprotective effects still raise large HDL particle concentrations by up to 40 percent, questioning what HDL particle size means (Clin Chem 2009)
- CETP gene variants that raise HDL cholesterol actually lower diastolic blood pressure, arguing the hypertension seen with torcetrapib is compound specific (Pharmacogenet Genomics 2008)
- Genetically low CETP predicts higher 10-year mortality in statin-treated men with coronary artery disease (Eur Heart J 2008)
- CETP Taq1B B2 variant cuts metabolic syndrome risk by up to 57% in a large Austrian cohort (Obesity (Silver Spring) 2008)
- Combined CETP- and hepatic-lipase-lowering gene variants raise HDL cholesterol but still increase coronary disease risk in the REGRESS trial (Atherosclerosis 2008)
- CETP TaqIB B1B1 genotype predicts sudden death in type 2 diabetes, an effect independent of its HDL cholesterol impact (Diabetes Care 2007)
- Hepatic lipase and CETP gene variants interact to raise HDL-C, but the combined genotype does not lower cardiovascular risk (J Clin Endocrinol Metab 2007)
- CETP haplotype linked to higher HDL-C across three populations shows no association with coronary heart disease risk (Hum Genet 2007)
- A rare long CETP allele raises coronary artery disease risk nearly 7-fold in Corsican patients (Exp Mol Pathol 2006)
- A longevity-associated CETP genotype preserves cognitive function in two independent cohorts (Neurology 2006)
- Dense genotyping of the CETP gene in over 2,000 people pinpoints a promoter SNP at position -4,502 as likely functional for HDL cholesterol (J Lipid Res 2007)
- Higher plasma CETP concentration, but not CETP genotype, predicts fewer cardiovascular events in pravastatin-treated coronary disease patients (J Intern Med 2006)
- CETP TaqIB rare allele is linked to lower internal carotid artery thickness in men, in the Framingham Heart Study (Atherosclerosis 2006)
- CETP D442G mutation raises HDL cholesterol in Vietnamese schoolgirls regardless of nutritional status (Pediatr Res 2005)
- CETP TaqI B1/B2 genotype differs significantly in men with venous thrombosis, tracking their low-HDL/high-LDL profile (Circulation 2005)
- CETP haplotype independently predicts triglyceride response to fluvastatin in familial hypercholesterolemia (Atherosclerosis 2005)
- CETP Taq1B genotype predicts who benefits from cardiac rehabilitation's lipid effects (Atherosclerosis 2005)
- CETP variants linked to HDL cholesterol are not the same ones linked to heart attack history, resolving a literature contradiction (Atherosclerosis 2005)
- CETP Taq1B genotype interacts with obesity in women and predicts small dense LDL in men in a 1029-person Austrian cohort (Biomed Pharmacother 2004)
- A moderate-expresser human-CETP transgenic rat model recapitulates female athero-resistance seen in humans (Atherosclerosis 2004)
- Novel CETP L296Q mutation discovered and linked to coronary heart disease and higher LDL cholesterol (Acta Biochim Biophys Sin (Shanghai) 2004)
- First evidence that CETP Taq1B genotype can guide statin therapy: B2 carriers benefit strongly, B1B1 homozygotes do not (Am Heart J 2003)
- CETP TaqIB genotype cuts cardiovascular risk 30% in non-smokers but not smokers in WOSCOPS (Eur Heart J 2003)
- Patients with atherogenic CETP genotypes get more HDL and triglyceride benefit from high-dose atorvastatin, DALI trial finds (Diabetes Care 2003)
- Haplotype analysis reveals that the famous CETP TaqIB polymorphism is not actually a driver of CETP or HDL cholesterol levels (J Mol Med 2003)
- Meta-analysis of over 10,000 people confirms both CETP TaqIB and I405V variants significantly raise HDL cholesterol (J Lipid Res 2003)
- CETP TaqIB and apoE genotypes interact to shape cholesterol levels in 7-year-old children (Nutr Metab Cardiovasc Dis 2002)
- CETP D442G mutation enlarges LDL particle size in coronary heart disease patients, suggesting an antiatherogenic role (Clin Chim Acta 2002)
- CETP B2B2 genotype raises HDL cholesterol and particle size specifically in women in the Columbia BioMarkers Study (Nutr Metab Cardiovasc Dis 2002)
- CETP TaqIB B2B2 genotype replicates its HDL cholesterol and coronary benefit in men with low HDL, VA-HIT trial finds (Arterioscler Thromb Vasc Biol 2002)
- CETP genotype shapes which HDL subfractions rise with endurance exercise training (Metabolism 2002)
- CETP D442G mutation flips its effect in fetal blood, lowering cholesterol instead of raising HDL as it does in adults (Atherosclerosis 2002)
- Statins should benefit CETP TaqIB B1B1 carriers most, since they have the highest baseline CETP activity (J Atheroscler Thromb 2002)
- CETP found directly inside atherosclerotic plaque foam cells, revealing an anti-atherogenic role in cholesterol removal at the earliest step of reverse transport (Atherosclerosis 2001)
- CETP TaqIB B2 allele produces a less atherogenic lipid profile and fewer clinical signs in familial hypercholesterolemia (Metabolism 2001)
- Extra-large HDL particles unique to genetic CETP deficiency may mark reduced atherosclerosis risk (Clin Chim Acta 2000)
- CETP-HDL relationships differ by sex, and CETP genotype does not explain Israel's low population HDL levels (Atherosclerosis 2000)
- New CETP promoter repeat marker links the gene to LDL particle size, triglycerides, and apoB in twins (Circulation 2000)
- CETP genotype combined with apoB signal peptide variant is the strongest predictor of hepatic apoB-100 secretion in obese men (J Lipid Res 2000)
- CETP TaqIB genotype raises HDL-cholesterol and lowers coronary disease only in men with type 2 diabetes (J Clin Endocrinol Metab 1999)
- ApoE4 allele blunts the correlation between CETP activity and LDL cholesterol during colestipol and lovastatin treatment (Eur J Clin Pharmacol 1999)
- A bimodal CETP concentration pattern hints at hidden CETP mutations linked to I405V, raising heart disease risk in men with high triglycerides (J Lipid Res 1998)
- Blocking apoB mRNA editing doubles plasma apoB-100 and shifts cholesterol from HDL to LDL specifically in CETP transgenic mice (Arterioscler Thromb Vasc Biol 1998)
- First Caucasian North American case of CETP deficiency traced to a novel exon 9 stop mutation (J Lipid Res 1998)
- Nearly 50,000-subject Japanese study finds no excess coronary heart disease in CETP-deficient people with very high HDL cholesterol (Prev Med 1998)
- CETP expression suppresses liver LDL receptor mRNA in ApoB/CETP double transgenic mice, reversible by oncostatin M (Arterioscler Thromb Vasc Biol 1997)
- CETP deficiency raises HDL-C in familial hypercholesterolemia but fails to prevent coronary disease (Atherosclerosis 1997)
- CETP activity enhances plasma cholesteryl ester formation, confirmed in transgenic mice, hamsters, and humans with genetic CETP deficiency (Arterioscler Thromb Vasc Biol 1997)
- Novel CETP nonsense mutation G181X found in 5 of 294 Japanese hyperalphalipoproteinemic subjects (J Lipid Res 1996)
- Combined CETP and hepatic lipase deficiency drives atherosclerotic disease in some patients with marked high HDL (Arterioscler Thromb Vasc Biol 1995)
- LDL particles from CETP-deficient patients bind LDL receptors two to three times less avidly than normal LDL (Eur J Clin Invest 1995)
- CETP co-expression halves HDL cholesterol and roughly doubles VLDL cholesterol in mice modeling type III hyperlipoproteinemia (J Biol Chem 1994)
- A marker linked to the CETP locus shows significant linkage to plasma HDL-cholesterol levels in coronary disease families (Hum Genet 1994)
- CETP TaqIB B2B2 genotype raises HDL2 by 45 percent independent of CETP exchange activity itself (Arterioscler Thromb 1994)
- ApoE genotype has opposite effects on CETP and HDL-cholesterol responses to dietary cholesterol (J Lipid Res 1993)
- CETP activity is twofold higher in familial hypercholesterolemia, linked to worse IDL and HDL composition (Horm Metab Res 1992)
- The human CETP gene transcript is alternatively spliced to skip exon 9, producing an inactive, poorly secreted protein variant (Biochemistry 1992)
- CETP-deficient patients carry two distinct LDL particle species in every density subfraction, suggesting a second LDL formation pathway (Arterioscler Thromb 1991)
- Cloning cynomolgus monkey CETP reveals hepatic mRNA rises fourfold with diet and correlates inversely with HDL cholesterol (ATVB 1991)
- A new immunoassay confirms plasma CETP protein, not just activity, is absent in patients with CE transfer deficiency (Clin Chim Acta 1990)
- The human CETP gene spans 25 kb with 16 exons and shares a signal-sequence motif with lipoprotein lipase and apoA-I/A-IV (Biochemistry 1990)
- CETP TaqI B polymorphism shows a dosage effect on apoA-I levels, limited to nonsmokers (Clin Genet 1989)
- Mendelian randomisation suggests genetically proxied CETP inhibition may lower intracranial aneurysm risk (Neurosurg Rev 2026)
- CETP rs3764261 T allele, a known atherosclerosis-protective variant, is linked to protection against eye inflammation after brolucizumab (Genes 2025)
- Mendelian randomization links CETP inhibition to lower lacunar stroke risk via cerebral small vessel disease genetics (Brain 2025)
- Genetic CETP deficiency review: heterozygotes have lower ASCVD risk, homozygotes show no excess risk, and very high HDL-C raises AMD questions (J Atheroscler Thromb 2025)
- Predicted CETP and LPL cardiovascular risk genotypes are most prevalent in populations with Native American ancestry (Mol Biol Rep 2025)
- Mendelian randomization links CETP inhibition and elevated LDL cholesterol to Lewy body dementia risk (Prog Neuropsychopharmacol Biol Psychiatry 2025)
- Genetic proxies for CETP inhibition are linked to lower preeclampsia risk in a Mendelian randomization study (Int J Womens Health 2025)
- CETP variants show BMI-dependent associations with atherogenic lipids and glucose traits in gestational diabetes (J Matern Fetal Neonatal Med 2024)
- Mendelian randomization finds genetically raised HDL via CETP predicted to lower small vessel stroke risk (J Am Heart Assoc 2024)
- CETP gene polymorphisms are linked to blunted heart rate response to exercise, first study of its kind reports (Int J Mol Sci 2024)
- Mendelian randomisation: genetically proxied CETP inhibition cuts abdominal aortic aneurysm risk (OR 0.127) but shows no benefit for calcific aortic valve stenosis (Rev Cardiovasc Med 2024)
- Mendelian randomization links the LDL-lowering effect of CETP to reduced obstructive sleep apnea risk (Toxicol Appl Pharmacol 2024)
- Mendelian randomisation flags genetically proxied CETP inhibition as associated with higher male infertility risk, partly via vitamin D (Front Endocrinol 2024)
- CETP variants, an update: a review maps how CETP structure, animal models and SNPs shape lipid profiles and cardiovascular risk (Curr Pharm Des 2024)
- Mendelian randomisation across nine drug targets and half a million lifespans finds genetically proxied CETP inhibition extends life expectancy (Lipids Health Dis 2023)
- Genome-wide interaction analysis pinpoints a CETP variant that modifies how sedentary behavior affects HDL cholesterol (Nutrients 2023)
- CETP gene haplotypes raise cardiovascular risk partly through mechanisms independent of triglycerides and HDL cholesterol (Int J Mol Sci 2023)
- Adcy9 gene inactivation shrinks infarct size and preserves cardiac function after MI, but mainly when CETP is absent (Can J Cardiol 2023)
- A multiancestry Mendelian randomization study suggests CETP inhibition may protect against preeclampsia via HDL cholesterol (Hypertension 2023)
- Mendelian randomization identifies CETP inhibition as a potential heart failure prevention strategy, acting mainly through apoB (Eur J Prev Cardiol 2023)
- Sex and BMI modify how much genetically lower CETP raises HDL-C and lowers LDL-C, though not cardiovascular outcomes (Genet Epidemiol 2023)
- Meta-analysis of 70 studies confirms CETP rs708272 is linked to lower coronary artery disease risk and higher HDL cholesterol (Front Cardiovasc Med 2023)
- CETP missense variants raise HDL cholesterol mainly by reducing protein secretion, not intrinsic lipid-transfer activity (PLoS One 2023)
- Mendelian randomisation finds genetically proxied CETP inhibitors protect against sepsis, an effect explained largely by ApoA-I (Front Cardiovasc Med 2023)
- Rare CETP missense variants are linked to male-specific metabolic syndrome across five ancestries, transethnic exome study finds (Genes Genomics 2022)
- A novel hypothesis links high East Asian CETP deficiency prevalence to historical resistance against a liver-damaging parasite (Front Cell Dev Biol 2022)
- CETP haplotypes predict whether lipophilic statins help or harm cognition in Alzheimer's disease (J Alzheimers Dis 2022)
- CETP promotes triglyceride storage in liver and intestinal cells, unlike its fat-reducing effect in adipocytes (Lipids 2021)
- Beyond failed HDL trials: a review argues the dal-GenE genomic-test approach to dalcetrapib and ADCY9 is the key to actionable HDL therapy (J Cardiovasc Pharmacol 2021)
- CETP gene variants predict residual atherogenic dyslipidaemia in Thai patients on statin therapy (Pharmgenomics Pers Med 2021)
- A loss-of-function CETP variant raises HDL cholesterol without raising ApoA1 or protecting against heart attack in Chinese patients (Nutr Metab Cardiovasc Dis 2021)
- CETP inhibitors in precision medicine: a review ties three phase 3 failures, the shelving of anacetrapib over fat accumulation, and the ADCY9 pharmacogenomic clue together (Clin Chim Acta 2020)
- First Samoan genome-wide association study confirms CETP-HDL cholesterol link in a previously unstudied Polynesian population (J Hum Genet 2020)
- CETP variant rs5882 carries a 25-fold higher risk of atrophic age-related macular degeneration in a Lithuanian case-control study (Mol Genet Genomic Med 2020)
- CETP promoter variant rs1800775 reduces the odds of essential hypertension in a Mexican population (Genet Test Mol Biomarkers 2020)
- CETP variant rs708272 shows a striking association with childhood HDL cholesterol and triglycerides in a pan-European cohort (Sci Rep 2020)
- dal-GenE trial design: only patients with the ADCY9 AA genotype will be enrolled, testing whether the benefit of dalcetrapib is genetically confined (Am Heart J 2020)
- In 1,855 Ghanaian adults, CETP variant rs17231520 is the leading genetic signal for HDL cholesterol, replicating a finding rare in West African cohorts (Front Genet 2020)
- CETP variant rs708272 doubles the risk of myocardial infarction in men from Western Siberia (Biomolecules 2019)
- CETP promoter variants that raise HDL cholesterol also lower the risk of type 2 diabetes and diabetic kidney disease in Taiwanese adults (Genes 2019)
- GWAS of 10,093 Indians finds CETP the primary genetic locus for metabolic syndrome, with a seven-variant haplotype as the strongest signal (Biomolecules 2019)
- Rare CETP variants found in most Korean adults with extremely high HDL cholesterol, but do not alter cholesterol efflux (Sci Rep 2019)
- Do CETP inhibitors have a role in treating cardiovascular disease? A review weighs harm, futility and modest benefit against emerging genomic clues (Am J Cardiovasc Drugs 2019)
- Genetic CETP deficiency loads HDL with apoE, apoC-III, ANGPTL3 and complement proteins, offering a clue why high HDL-C doesn't protect these patients (J Clin Lipidol 2019)
- CETP variant rs1800777 predicts low HDL cholesterol and acute kidney injury risk during sepsis, replicated across two cohorts (Sci Rep 2018)
- ADCY9 inactivation cuts atherosclerosis by 65 percent in mice, but only when CETP is absent (Circulation 2018)
- CETP I405V variant shows a strong, first-reported association with ischemic stroke risk in a Caucasian population (J Stroke Cerebrovasc Dis 2018)
- CETP Taq1B combined with an NOS3 variant multiplies the risk of type 2 diabetes and cardiovascular disease eightfold (Cardiovasc Diabetol 2018)
- Weight gain prevention counteracts the HDL-lowering effect of CETP variant rs3764261 in young adults, randomized trial finds (Nutr Metab Cardiovasc Dis 2018)
- CETP variant rs708272 raises acute coronary syndrome risk and shifts HDL subclass cholesterol content (Lipids 2018)
- Lower serum CETP levels found in the oldest members of Greek long-lived families (Open Cardiovasc Med J 2018)
- CETP variant rs1800777 A allele linked to milder liver damage in fatty liver disease (Ann Nutr Metab 2018)
- The CETP I405V polymorphism is an independent risk factor for Alzheimer's and vascular dementia in a Southern Italian cohort (J Alzheimers Dis 2018)
- A well-powered Mendelian randomization study finds CETP-driven HDL cholesterol is not associated with Alzheimer's disease risk (Alzheimers Dement 2018)
- Mendelian randomization finds no overall causal link between genetically determined CETP and carotid intima-media thickness (J Clin Lipidol 2018)
- CETP TaqIB B2B2 genotype blunts cholesterol-lowering response to simvastatin in Thai patients (Cardiovasc Ther 2017)
- Pharmacogenetics of HDL-targeting and statin therapies: dal-OUTCOMES and dal-PLAQUE-2 gave concordant results for dalcetrapib in the favourable genotype (Curr Atheroscler Rep 2017)
- Meta-analysis confirms the CETP TaqIB B2 allele protects against ischemic stroke (J Stroke Cerebrovasc Dis 2017)
- Five of six CETP polymorphisms are linked to metabolic syndrome in Uyghur adults, with two protective haplotypes identified (Int J Environ Res Public Health 2017)
- Mendelian randomization finds HDL-raising CETP variants also raise the risk of age-related macular degeneration (Ophthalmology 2017)
- CETP knockout rabbits show less atherosclerosis, better cholesterol efflux, and HDL that suppresses endothelial adhesion molecules (Arterioscler Thromb Vasc Biol 2017)
- A year of Mediterranean diet raises HDL cholesterol and lowers triglycerides specifically in carriers of the CETP rs3764261 T allele, CORDIOPREV trial finds (Clin Nutr 2018)
- CETP rs708272 B2 allele is linked to a more antiatherogenic LDL subfraction profile in statin-treated coronary heart disease patients (Biochem Genet 2016)
- Meta-analysis of over 40,000 subjects confirms CETP TaqIB B1 allele raises ischemic cardiovascular disease risk and lowers HDL cholesterol (Int J Environ Res Public Health 2016)
- CETP TaqIB and I405V variants strongly linked to centenarian status in Hainan, China (Asian Pac J Trop Med 2016)
- Two CETP variants have opposite effects on coronary artery disease risk in the first such study in Saudi Arabians (Hum Genomics 2016)
- A protective CETP variant buffers the memory-decline effect of APOE4 in older adults (Neurobiol Aging 2016)
- Resequencing the entire CETP gene uncovers rare variants that independently affect HDL cholesterol in both whites and African blacks (Metabolism 2016)
- Two linked upstream CETP variants have opposite effects on gene expression via disrupted transcription factor binding sites (Pharmacogenet Genomics 2015)
- CETP deficiency protects against fatal liver damage from schistosomiasis by starving parasite eggs of HDL cholesteryl ester (J Biomed Res 2015)
- The CETP B2 allele is linked to lower LDL cholesterol specifically in black, not white, South African women (Atherosclerosis 2015)
- Combined CETP B1 and eNOS 4a alleles raise coronary artery disease risk up to 34-fold in Malay and Indian, but not Chinese, ethnic groups (Clin Appl Thromb Hemost 2016)
- Overexpressing full-length CETP in fat cells cuts triglyceride accumulation in half by boosting turnover and blocking synthesis (J Lipid Res 2015)
- Atorvastatin fails to protect against atrial fibrillation in patients with the CETP TaqIB B2B2 genotype (J Atr Fibrillation 2015)
- Fine-mapping of the CETP region identifies five novel variants, including a common intronic insertion, linked to HDL-C (NPJ Aging Mech Dis 2015)
- Meta-analysis of over 17,000 subjects confirms CETP TaqIB B2B2 genotype protects against myocardial infarction (Medicine 2014)
- Review from the discoverer of CETP deficiency in Japan surveys anacetrapib and evacetrapib as candidate cures for atherogenic dyslipidemia (Mol Cells 2014)
- CETP TaqIB B2 homozygotes get the strongest heart-protective benefit from moderate alcohol intake, replicating a prior finding in men (Alcohol 2014)
- Cache County Study links CETP I405V valine allele to slower cognitive decline in 4,486 older adults (Neurobiol Aging 2015)
- Ten CETP locus SNPs are among the strongest genetic determinants of HDL cholesterol variability in a Latvian population (Meta Gene 2014)
- Meta-analysis links the CETP rs5882 A allele to increased Alzheimer's disease risk in Caucasians (DNA Cell Biol 2014)
- The CETP rs5882 variant predicts white matter microstructure, with opposite effects in young versus older adults (Neurobiol Aging 2014)
- CETP and APOE variants interact to raise hypertriglyceridemia risk in oldest-old Chinese women (Exp Gerontol 2014)
- CETP variant rs3764261 is linked to reduced risk of advanced age-related macular degeneration in a Chinese population (Ophthalmic Genet 2015)
- A single CETP gene variant, rs5883, is identified as the main driver of the exon-9-skipping splice form (Biochem Biophys Res Commun 2014)
- Meta-analysis of seven CETP variants finds rs708272 and rs1800775 are promising biomarkers for myocardial infarction risk (PLoS One 2014)
- CETP TaqIB B2B2 genotype raises atrial fibrillation risk, especially in postmenopausal women with higher triglycerides (J Atr Fibrillation 2014)
- HDL from genetically CETP-deficient carriers is worse at activating eNOS, despite normal cholesterol-efflux capacity (PLoS One 2014)
- CETP deficiency linked to cardiovascular disease and stroke within a high-HDL syndrome, especially in women (Mol Genet Metab Rep 2014)
- Review asks whether anacetrapib and evacetrapib can succeed where torcetrapib and dalcetrapib failed to reduce cardiovascular risk (Annu Rev Med 2014)
- The CETP rs1532624 AA genotype has lower CETP activity, higher HDL-C, but a weaker LDL-C response to statins in Jordanian patients (Curr Mol Pharmacol 2013)
- CETP Taq1B B1/B1 genotype predicts a favorable triglyceride/HDL-C response to kiwifruit in hypercholesterolaemic men (Br J Nutr 2013)
- CETP B1B1 genotype tracks with lower HDL cholesterol from birth through age 5-6 in children at cardiovascular risk (Med Sci Monit 2013)
- CETP genetic variants do not predict recurrent heart attacks in secondary prevention patients, but may raise mortality after bypass surgery (Am J Cardiol 2013)
- CETP I405V polymorphism is an independent risk factor for endometriosis in a case-control study of women (Gynecol Endocrinol 2013)
- CETP is the single most common genetic factor influencing HDL cholesterol in the Latvian population, ten-SNP association study finds (PLoS One 2013)
- Novel CETP promoter variants found in hyperalphalipoproteinemia patients sharply cut gene transcriptional activity (Clin Chim Acta 2013)
- Meta-analysis of over 15,000 subjects finds the CETP TaqIB B1 allele raises coronary artery disease risk specifically in Han Chinese (Mol Biol Rep 2013)
- CETP B1 allele combined with an eNOS variant raises coronary artery disease risk 18-fold in Western Iranians (Hum Genomics 2012)
- A distinct HDL-like particle seen in complete genetic CETP deficiency is absent in dalcetrapib-treated volunteers (Curr Vasc Pharmacol 2012)
- CETP -629 AA genotype is enriched in metabolic syndrome patients and linked to lower CETP but higher LDL-C and total cholesterol (Mol Biol Rep 2012)
- Common CETP genetic variants do not alter how well the apoB/apoA-I ratio predicts first major cardiovascular events compared with TC/HDL-C (J Clin Lipidol 2012)
- Resequencing finds rare CETP mutations and a common variant far more often in Thai patients with very high HDL cholesterol (Am J Cardiol 2012)
- CETP I405V valine homozygosity is linked to better cognitive function after age 65 (Neurobiol Aging 2012)
- CETP polymorphisms are linked to brain structure and Alzheimer's risk in an APOE-dependent manner (Brain Imaging Behav 2012)
- Low CETP activity more than doubles coronary artery disease risk in an Asian Indian diabetic cohort (Pharmacogenet Genomics 2012)
- CETP variant rs9923854 enriched in the oldest-old across Danish and German cohorts (Age (Dordr) 2012)
- Contradicting earlier reports, the CETP I405V polymorphism is linked to faster cognitive decline and higher Alzheimer's risk in a large US cohort (Aging Cell 2012)
- A novel CETP promoter deletion causing CETP deficiency does not impair HDL function in reverse cholesterol transport (Atherosclerosis 2011)
- CETP Taq1B B1B1 genotype independently raises type 2 diabetes risk, and a hepatic lipase variant amplifies it further (PLoS One 2011)
- CETP promoter variant -629C>A is strongly linked to cardiovascular disease specifically in Asian Indian patients with type 2 diabetes (J Diabetes Complications 2011)
- CETP variants raise HDL cholesterol by up to 14 percent regardless of diet, alcohol, or diabetes status in a high-risk Mediterranean population (J Lipid Res 2010)
- CETP TaqIB fails to protect against coronary heart disease over 10 years despite raising HDL cholesterol, and even raises risk in drinkers (Atherosclerosis 2010)
- CETP TaqIB B1B1 men are most responsive to a high-carbohydrate low-fat diet's HDL-raising effect in young Chinese adults (J Nutr Biochem 2010)
- CETP TaqIB genotype determines whether atorvastatin raises or lowers HDL cholesterol (Open Cardiovasc Med J 2010)
- CETP TaqIB B2 allele partly protects against the atherogenic HDL profile of type 2 diabetes, but only in women with milder insulin resistance (Atherosclerosis 2010)
- CETP Taq1B B1B1 genotype is linked to higher insulin and HOMA levels, suggesting a role in glucose regulation (Nutr Metab Cardiovasc Dis 2011)
- Rare CETP-deficient case reveals independent control of remnant triglyceride and cholesterol after a fat load (Ann Clin Biochem 2009)
- Two new CETP and LIPC gene mutations identified as causes of extremely high HDL cholesterol in Thai patients (Metabolism 2009)
- CETP variant D442G raises HDL cholesterol nearly three times more in obese than normal-weight Chinese individuals (Obesity 2009)
- The CETP SNP rs1800775 explains more variance in HDL cholesterol than any other single lipid gene variant studied in older adults (Eur Heart J 2009)
- CETP locus generalizes as a blood-lipid determinant across black, Mexican American, and white US populations (Circ Cardiovasc Genet 2009)
- CETP TAQIB and I405V rare alleles are modestly associated with reduced obesity risk in Chinese adults, largely via HDL levels (Acta Diabetol 2009)
- A CETP variant raises vascular dementia risk and lowers white matter lesion load, but only in APOE4 non-carriers (J Neural Transm 2009)
- CETP TaqIB B2B2 genotype more than doubles cardiovascular death risk after acute coronary syndrome, unless the patient takes a statin (Clin Chem Lab Med 2009)
- Serum cholesterol efflux capacity is preserved or enhanced in genetically CETP-deficient patients (Clin Chim Acta 2008)
- A review notes a meta-analysis linking CETP-lowering alleles to reduced coronary heart disease, distinct from the off-target failure of torcetrapib (J Lipid Res 2009)
- First CETP gene mutations identified in Italian patients with extremely high HDL cholesterol, including two premature-stop-codon variants (Atherosclerosis 2009)
- CETP haplotype G raises early-onset heart-attack risk up to 6-fold in men, independent of HDL-C (Ann Hum Genet 2008)
- Updated pooled analysis finds the CETP B2 allele may raise, not lower, cardiovascular risk in the general population despite higher HDL cholesterol (Pharmacogenomics 2008)
- Both wild-type CETP and its poorly secreted splice variants trigger the same endoplasmic reticulum stress response (J Lipid Res 2008)
- Two novel CETP protein variants identified through resequencing in individuals of Asian ancestry, both partly functional (Atherosclerosis 2009)
- CETP B1B1 genotype combined with APOE or APOC3 risk variants quadruples coronary artery disease risk when all three are present (Atherosclerosis 2008)
- Glucocorticoid replacement erases the CETP promoter variant's link to HDL cholesterol in hypopituitary patients (Clin Endocrinol (Oxf) 2008)
- CETP promoter variant linked to lower CETP levels also impairs the ability of plasma to remove cholesterol from cells, a possible clue to its cardiovascular risk (Biochim Biophys Acta 2008)
- Alcohol only reduces heart disease risk in CETP TaqIB B2 carriers, especially among women, two large US cohort studies find (Eur Heart J 2008)
- CETP Taq1 B2 allele nearly halves ischemic stroke risk in Sardinian women, but not men (J Intern Med 2007)
- Smoking advances first heart attack by up to 9 years in CETP TaqIB B1 carriers, but not in B2B2 homozygotes (Ann Noninvasive Electrocardiol 2007)
- Three newly discovered rat gene loci determine whether human CETP causes severe hypercholesterolemia when expressed as a transgene (J Hypertens 2007)
- CETP I405V VV genotype cuts myocardial infarction risk in men by 43 percent in the Rotterdam Study (Eur J Cardiovasc Prev Rehabil 2007)
- White women with a CETP -629 A/A genotype gain the most HDL cholesterol from 20 weeks of endurance training (Physiol Genomics 2007)
- The Rotterdam Study links CETP I405V VV genotype to increased Alzheimer's disease risk in APOE4 non-carriers (Neurogenetics 2007)
- Rare CETP variants, not the common TaqIB marker, best explain the link of the gene to coronary artery disease in 4,811 patients (J Am Coll Cardiol 2007)
- CETP expression reverses the obesity caused by apolipoprotein CIII overexpression in transgenic mice (Int J Obes 2007)
- CETP deficiency sharply blunts the post-meal triglyceride spike and remnant lipoprotein formation (Atherosclerosis 2008)
- CETP B2B2 genotype protects against acute coronary syndrome only in normal-weight Greeks, not the overweight or obese (Hum Hered 2007)
- CETP gene variants predict how much fat monozygotic twins gain during 100 days of deliberate overfeeding (Atherosclerosis 2008)
- A novel CETP splice-site mutation causes isolated high HDL cholesterol in Caucasians, distinct from ordinary hyperalphalipoproteinemia (J Lipid Res 2007)
- CETP is one of only four genes with consistent lipid effects across sex and race in the CARDIA cohort (Arterioscler Thromb Vasc Biol 2006)
- CETP Taq1B B1 allele linked to worse lipid profile and higher blood pressure in kidney transplant patients (Transplant Proc 2006)
- CETP TaqIB is the only tested genetic system linked to atrial fibrillation, especially when combined with kidney or inflammation markers (BMC Med Genet 2006)
- Two novel CETP gene variants are found in humans, and torcetrapib inhibits both variant and normal CETP equally (Biochim Biophys Acta 2005)
- Full gene screening finds 12 novel CETP variants, three of which raise coronary heart disease risk in Chinese patients (Int J Cardiol 2005)
- The CETP C-629A promoter variant modifies the Alzheimer's disease risk conferred by APOE epsilon4 (J Neurol 2006)
- REGRESS Study identifies three interacting CETP promoter variants that jointly determine plasma CETP concentration (Hum Mol Genet 2005)
- CETP B2B2 homozygotes gain over ten times more HDL cholesterol from simvastatin than B1 carriers, unlike APOE or LIPC genotypes (Clin Chim Acta 2005)
- CETP TaqI B1B2 genotype triples hypertension risk in North Indian diabetics despite no direct T2DM link (BMC Endocr Disord 2005)
- High triglycerides nearly halve the HDL-raising benefit of a protective CETP promoter variant, large PREVEND study finds (J Clin Endocrinol Metab 2005)
- Torcetrapib inhibits every common CETP genetic variant equally, even the two that are naturally more stable in the body (J Biol Chem 2005)
- A newly characterized CETP promoter variant raises HDL cholesterol specifically in African Americans by weakening a transcription-factor binding site (Clin Genet 2004)
- CETP TaqB1B1 genotype linked to higher LDL cholesterol in Chinese coronary heart disease patients (Chin Med J (Engl) 2004)
- Genome scan finds an LDL-particle-size linkage locus near CETP in familial combined hyperlipidemia families (Arterioscler Thromb Vasc Biol 2004)
- CETP -629A is one of only two individual gene variants, out of 58 tested, that protect against myocardial infarction (Eur Heart J 2004)
- Elderly men carrying a CETP mutation trend toward the lowest heart disease rates in a 7-year Honolulu Heart Program follow-up (J Lipid Res 2004)
- Review catalogs ten CETP mutations behind hyperalphalipoproteinemia in Japanese CETP-deficient subjects (J Atheroscler Thromb 2004)
- CETP deficiency produces giant HDL particles carrying nearly every major apolipoprotein except apoA-IV (J Lipid Res 2004)
- Japan CETP Study Group finds CETP activity is the strongest determinant of both HDL-C and LDL-C in 591 subjects (Metabolism 2003)
- Hepatic lipase TT genotype protects against vascular disease only in hemodialysis patients with high CETP levels (Kidney Int 2003)
- CETP I405V genotype determines whether dietary plant sterols lower cholesterol and CETP concentration (J Nutr 2003)
- Full resequencing pinpoints the specific CETP promoter and repeat variants most strongly linked to CETP mass and HDL cholesterol (Atherosclerosis 2003)
- Review surveys CETP as both an unresolved genetic risk marker and a newly validated drug target (Curr Opin Lipidol 2003)
- CETP -629A allele linked to larger LDL particle size in 377 healthy middle-aged men (Atherosclerosis 2003)
- A newly discovered CETP splice variant in rabbit intestine, and its human counterpart, lacks the lipid-transfer-critical carboxy-end (Mol Cell Biochem 2003)
- REGRESS study haplotype analysis shows -629C/A, not TaqIB, drives CETP concentration and HDL-C (Hum Mol Genet 2003)
- CETP mutations explain most, but not all, cases of extremely high HDL cholesterol in 624 Japanese patients (Atherosclerosis 2003)
- CETP variants cannot explain why Asian Indians have both the highest heart disease rates and lowest HDL cholesterol in Singapore (Clin Genet 2003)
- CETP Taq1B B1B1 genotype independently predicts coronary artery disease in Koreans (Clin Genet 2003)
- CETP gene haplotypes, not individual SNPs, are the first shown to predict lipid response to statin therapy (Pharmacogenomics J 2003)
- Two newly discovered CETP mutations block protein secretion, explaining more than 60 percent of severe high-HDL cases in Japan (J Lipid Res 2002)
- CETP TaqIB B2 allele is less common in African Americans than Caucasians, ruling it out as an explanation for higher HDL-C (Atherosclerosis 2002)
- D442G CETP mutation raises HDL cholesterol in Korean postmenopausal women but does not alter the HDL response to hormone therapy (Korean J Intern Med 2002)
- CETP TaqIB B2 carriers have higher HDL cholesterol but no lower heart attack risk in a large Physicians Health Study cohort (Atherosclerosis 2002)
- CETP activity does not predict LDL buoyancy in women, but CETP TaqIB genotype does predict CETP mass and HDL3 cholesterol (Arterioscler Thromb Vasc Biol 2002)
- Novel CETP promoter variant -971G/A found to be a non-functional marker linked to HDL-C via other polymorphisms (Atherosclerosis 2002)
- CETP TaqIB B1B1 genotype independently predicts coronary disease, arteriosclerosis, and stroke in Japanese type 2 diabetics (Diabetes 2002)
- CETP EcoN1 GG genotype linked to coronary heart disease risk in a Taiwanese population survey (Atherosclerosis 2001)
- CETP TaqIB predicts heart attack risk and a 2-year later age of onset, but a linked promoter variant does not, Reykjavik Study finds (Atherosclerosis 2001)
- The CETP D442G mutation raises HDL cholesterol in adults but not children, first pediatric study of this variant finds (Pediatr Res 2001)
- CETP deficiency slows parasite egg development, a possible reason it persists at high frequency across East Asia (Biochem Biophys Res Commun 2001)
- Suppressing CETP synthesis in fat cells causes cholesteryl ester to pile up threefold by blocking its normal mobilization (J Biol Chem 2001)
- CETP Ile405Val predicts carotid intima-media thickness in men but not women in the Stanislas Cohort (Clin Genet 2001)
- Review details CETP's LBP-gene-family membership and the molecular basis of CETP-deficiency hyperalphalipoproteinemia (Biochim Biophys Acta 2000)
- Review highlights a paradox: CETP-inhibited rabbits show different atherogenicity than genetically CETP-deficient humans (Curr Opin Lipidol 2000)
- CETP B1B1 genotype predicts a larger cholesterol drop from switching to a low-saturated-fat diet, crossover trial finds (Atherosclerosis 2000)
- A review argues CETP-TaqI-B polymorphism data support genetic testing, while cautioning that CETP-inhibitor cardioprotection remains unproven (Clin Chem Lab Med 2000)
- Review concludes CETP's atherogenic effect depends on metabolic background, proposing it as a therapeutic target in hyperlipidemia (Curr Opin Lipidol 2000)
- Ten CETP polymorphisms mapped in 568 heart-attack patients reveal alcohol-dependent effects on HDL cholesterol (Genet Epidemiol 2000)
- New CETP/-629 promoter variant lowers CETP mass and raises HDL cholesterol via Sp1/Sp3 repression (ATVB 2000)
- CETP variant R451Q lowers carotid artery thickness in men, while I405V harms only heavy drinkers (Eur J Clin Invest 2000)
- Blocking CETP production in liver cells boosts secretion of the smallest, most protective HDL form (Atherosclerosis 1999)
- Abdominal obesity blunts the HDL-raising benefit of the CETP B2 allele in men with insulin resistance features (Int J Obes 1999)
- CETP genotype, not insulin sensitivity, predicts how PLTP activity falls during hyperinsulinemia in men (J Lipid Res 1999)
- Human CETP transgene worsens atherosclerosis in apoE- and LDL-receptor-knockout mice, but effect flips with apoA-I overexpression (ATVB 1999)
- Two CETP variants jointly explain 12 percent of CETP activity variance in a European multi-country cohort, EARS study finds (Eur J Clin Invest 1999)
- SREBP-1 activates the CETP gene in transgenic mice but is not required for its cholesterol-driven up-regulation (J Biol Chem 1998)
- New CETP mutation R451Q raises CETP activity in men but lowers cholesterol in women, a sex-divergent effect (Atherosclerosis 1998)
- CETP TaqIB genotype predicts opposite lipid responses to a cholesterol-lowering diet in type 1 diabetics (Diabetes 1997)
- A novel CETP nonsense mutation produces a paradoxical combination of very high HDL cholesterol and extreme post-meal triglyceride levels (Arterioscler Thromb Vasc Biol 1997)
- Chemically blocking a single CETP cysteine residue selectively shuts off triglyceride transfer while leaving cholesteryl ester transfer intact (Biochim Biophys Acta 1997)
- Exon-14 skipping explains why the common Japanese CETP splicing mutation produces essentially no detectable protein (Arterioscler Thromb Vasc Biol 1997)
- ApoE-rich HDL is a better CETP substrate than apoA-II-containing HDL, three CETP-deficiency genotypes reveal (J Lipid Res 1997)
- Review surveys the molecular genetics of CETP deficiency and its still-controversial link to atherosclerosis (Curr Opin Lipidol 1997)
- CETP gene locus heterogeneity explains why healthy men with low HDL cholesterol carry higher CETP concentrations (ATVB 1997)
- Non-smoking, alcohol-drinking men with the CETP V405 genotype may have up to 40 percent lower heart attack risk, Icelandic study suggests (Clin Genet 1997)
- Transgenic mice map distinct CETP promoter regions controlling liver, intestine, and adrenal expression (J Biol Chem 1996)
- CETP gene variation explains one-fifth of the variability in plasma CETP levels, but not HDL cholesterol, family study finds (J Lipid Res 1996)
- A panel of 16 new antibodies maps four distinct CETP regions essential for cholesteryl ester transfer activity (J Lipid Res 1996)
- Review weighs whether cholesterol redistribution by CETP is proatherogenic or a step in protective reverse cholesterol transport (Horm Res 1996)
- Review surveys the biochemistry and molecular basis of CETP deficiency disorders (J Atheroscler Thromb 1996)
- CETP mutation 442D:G is found in nearly a third of Japanese with very high HDL cholesterol, including the first documented case with atherosclerosis (Atherosclerosis 1995)
- CETP TaqIB genotype distribution differs significantly between cholesterol gallstone patients and controls (J Lipid Res 1995)
- CETP deficiency yields abnormally large, cholesterol-rich apoA-I lipoprotein particles that bind but internalize poorly (Eur J Biochem 1995)
- Molecular genetics reveals CETP as both anti-atherogenic in human deficiency and pro-atherogenic when overexpressed in mice (J Intern Med 1995)
- CETP mutations I14A and D442G together explain a graded rise in HDL cholesterol across 226 Japanese patients (J Clin Endocrinol Metab 1994)
- ApoA-II shields HDL from CETP-driven shrinkage by inhibiting hepatic lipase in transgenic mice (J Clin Invest 1994)
- CETP TaqI B polymorphism predicts CETP activity and HDL cholesterol in non-smoking men, but alcohol and smoking alter the association (Atherosclerosis 1994)
- CETP EcoNI genotype 2-2 predicts higher rates of coronary disease and neuropathy in type 2 diabetes (Clin Genet 1994)
- CETP TaqI polymorphism predicts HDL cholesterol in Greek but not Italian migrants to Australia (Hum Biol 1994)
- An alternatively spliced CETP variant lacking exon 9 sequences blocks secretion of full-length CETP by forming inactive heteromeric complexes (J Biol Chem 1993)
- A CETP nonsense mutation at codon 309, detected via macrophage mRNA, is identified as a new cause of familial hyperalphalipoproteinemia (Biochem Biophys Res Commun 1993)
- Homozygous and heterozygous CETP deficiency show graded shifts toward cholesteryl-ester-rich HDL and cholesteryl-ester-poor IDL that track with serum CETP level (Atherosclerosis 1991)
- In CETP deficiency, LDL cholesteryl esters trace back to intracellular ACAT rather than CETP-mediated transfer from HDL (J Lipid Res 1991)
- CETP TaqIB genotype tracks with HDL cholesterol at the population extremes, with the B2 allele enriched among high-HDL subjects (Clin Sci 1990)
- ApoE-rich HDL that accumulates in CETP deficiency binds the LDL receptor with far higher affinity than LDL itself (J Clin Invest 1990)
- CETP locus DNA polymorphism acts as both a level gene for apoA-I and HDL cholesterol and a variability gene for LDL cholesterol (Acta Genet Med Gemellol 1990)
- Cloning rabbit CETP reveals 81% homology to the human protein and liver-dominant tissue expression across primates and rabbit (J Lipid Res 1988)
- Liver Hep G2 cells secrete CETP, acquiring asparagine-linked sugar and sialic acid during processing (J Biol Chem 1987)
- CETP shows the most consistent gene-diet interaction evidence of any lipid gene, especially with dietary fat composition (Curr Issues Mol Biol 2026)
- Cross-trait GWAS links hearing loss to HDL and triglyceride genetics, flagging CETP as a candidate druggable target (Mol Genet Genomics 2025)
- Largest paediatric lipid GWAS to date confirms CETP as a robust HDL locus in Indian schoolchildren, with rare CETP variants also implicated (J Hum Genet 2025)
- Blood gene-expression signature of ITGB3, VEGFA and CETP tracks the extent of coronary artery stenosis, odds ratio 7.49 (Biochemistry (Mosc) 2025)
- A hierarchical transformer model identifies an APOA4-CETP epistatic interaction underlying triglyceride to HDL cholesterol ratio (bioRxiv 2025)
- CETP promoter and coding variants predict HDL cholesterol levels in a Bangladeshi population (Biochem Biophys Rep 2025)
- CETP genetic variants shape the lipid response to statins in Alzheimer's disease patients (Sao Paulo Med J 2025)
- Systematic review finds PCSK9, CETP and CDKN2B-AS1 polymorphisms among the strongest genetic contributors to myocardial infarction in Saudi Arabia (J Saudi Heart Assoc 2025)
- Mendelian randomisation finds genetically proxied CETP inhibition associated with lower uterine fibroid risk (Heliyon 2025)
- Genome-wide meta-analysis of myopic macular neovascularisation finds the AMD-linked CETP locus rs12720922 also protects against this retinal disease (Ophthalmol Retina 2025)
- CETP rs708272 GG genotype blunts the benefit of a dietary intervention when trans fatty acid intake is high, secondary analysis finds (Nutrients 2024)
- Mendelian randomisation finds higher genetically predicted CETP, alongside HMGCR and PCSK9, associated with greater aortic aneurysm risk (Eur J Prev Cardiol 2024)
- The CETP rs708272 G/G genotype is significantly linked to dyslipidemia in Chinese patients with diabetes (World J Clin Cases 2024)
- CETP gene variants help explain HDL cholesterol levels in children with sickle cell disease (Braz J Med Biol Res 2024)
- Mendelian randomisation finds genetically higher CETP levels associated with increased non-endometrioid endometrial carcinoma risk (Front Endocrinol 2024)
- Traditional dietary pattern adherence modulates the CETP Taq1B link to triglyceride levels in angiography patients (Nutr J 2023)
- A CETP variant is one of four factors in a nomogram predicting behavioral symptoms in Alzheimer's disease (Chin Med J 2024)
- In a highly admixed population, four CETP gene variants explain part of the HDL-cholesterol variation across adolescents, adults and older adults (Clin Nutr ESPEN 2023)
- Dietary acid load interacts with CETP TaqB1 genotype to worsen lipid profile in B1B1 carriers with type 2 diabetes (BMC Endocr Disord 2023)
- A CETP variant is significantly associated with pentosan polysulfate (Elmiron) maculopathy, a genetic study of a drug-induced retinal disease finds (Retina 2023)
- The CETP rs708272 genotype predicts statin response only in women with hyperlipidaemia (Malays J Med Sci 2023)
- Mendelian randomization finds HDL cholesterol protective against diabetic retinopathy, but genetically proxied CETP inhibition shows no effect (Atherosclerosis 2023)
- Abdominal obesity combines with the CETP TaqIB variant to raise cholesterol in Mexican women (Lifestyle Genom 2023)
- The CETP rs708272 risk allele is linked to higher cardiac gene expression and interacts with diet and smoking to triple the risk of low HDL (Front Nutr 2023)
- Korean GWAS of 72,298 people finds a CETP variant significant for dyslipidaemia overall and a second one only in men (Lipids Health Dis 2022)
- A trans-ancestry GWAS in pregnant women finds the CETP locus approaches genome-wide significance for HDL cholesterol (J Clin Lipidol 2023)
- The CETP TaqIB B1B2/B2B2 genotype raises the risk of fatty liver disease in Mexican women with gallstones (Metab Syndr Relat Disord 2023)
- In two large Korean cohorts, whether CETP raises cholesterol with alcohol depends on a person's ALDH2 genotype (Sci Rep 2022)
- CETP gene promoter hypomethylation is associated with coronary artery disease risk in a Chinese Han cohort (Mol Biol Rep 2022)
- Two CETP gene variants raise coronary artery disease risk but do not predict restenosis after stenting (Arch Cardiol Mex 2022)
- CETP variant rs3764261 has a bigger population-level impact on low HDL cholesterol than smoking, Japanese cohort study finds (J Epidemiol 2022)
- Review of 49 studies finds the TaqIB CETP variant is the most widely studied gene-diet interaction affecting blood lipids (Curr Atheroscler Rep 2022)
- CETP mutations are identified for the first time in South Indian patients with familial hypercholesterolemia (Clin Chim Acta 2022)
- CETP variant rs3764261 emerges as a lean-mass protective marker in a Pakistani obesity genetics cohort (PLoS One 2022)
- Exome study in an underrepresented Mexican cohort finds a novel CETP variant, rs11076176, linked to higher risk of low HDL cholesterol (Front Genet 2022)
- The CETP TaqIB polymorphism interacts with diet quality to shape metabolic markers in type 2 diabetes (J Hum Nutr Diet 2022)
- The CETP rs5883 T allele is linked to higher HDL cholesterol and lower risk of low HDL in postmenopausal obese women (Eur Rev Med Pharmacol Sci 2021)
- CETP TaqB1 polymorphism interacts with dietary insulin index to shape cardiovascular risk in type 2 diabetes (Sci Rep 2021)
- CETP is used to illustrate why Mendelian randomization of drug targets differs methodologically from randomization of biomarkers (Nat Rev Cardiol 2021)
- GWAS confirms CETP as one of only three genome-wide loci for Lp(a) levels while discovering a novel APOH locus (Arterioscler Thromb Vasc Biol 2020)
- CETP variant rs3764261 is linked to polypoidal choroidal vasculopathy in a Portuguese population, but not in a Singaporean cohort (Br J Ophthalmol 2021)
- Fine-mapping in two Kuwaiti Arab cohorts flags rs1864163 in CETP as a candidate causal variant for HDL cholesterol (Hum Genet 2021)
- Carriers of the CETP Taq1B B2 allele only show worse cholesterol with a high-sucrose diet or physical inactivity, a gene-environment study finds (J Hum Nutr Diet 2020)
- Higher serum CETP levels are linked to acute coronary syndrome, with the association modified by TaqIB genotype (Lab Med 2020)
- Certain CETP gene haplotypes raise the triglyceride to HDL cholesterol ratio more often in Roma than Hungarian populations (Genes 2020)
- Korean GWAS discovers six novel CETP SNPs associated with low HDL cholesterol (PLoS One 2020)
- CETP variant rs5882 interacts with monounsaturated fat intake to affect triglyceride levels in overweight and obese adults (Lifestyle Genom 2020)
- CETP TaqIB genotype shapes how plant oils affect metabolic markers in people with diabetes (J Cardiovasc Thorac Res 2020)
- CETP genetic variants predict how much LDL cholesterol falls with statin therapy (Pharmacogenomics J 2020)
- Comparative genomics finds widespread natural loss of the CETP gene across placental mammals (NAR Genom Bioinform 2019)
- CETP variant rs6499861 lowers HDL cholesterol more strongly in obese Korean men and women with a family history of diabetes (J Lipid Atheroscler 2019)
- CETP variant rs708272 GG genotype cuts the odds of optic neuritis with multiple sclerosis by 62% in a Lithuanian case-control study (Ophthalmic Genet 2019)
- CETP Taq1B genotype shifts HDL and LDL subclass distribution in African-American men (Future Cardiol 2019)
- CETP variant rs708272 is linked to reduced risk of pituitary adenoma and its recurrence (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020)
- Fish intake and dietary fat modify how two CETP gene variants affect cholesterol and triglyceride changes over time (Eur J Clin Nutr 2019)
- CETP rs708272 raises HDL cholesterol and lowers atherogenic index in men but not women, without affecting coronary disease risk (Medicine 2018)
- CETP TaqIB genotype shapes HDL cholesterol but not diabetes risk in Southern Thai adults (Arch Med Res 2018)
- Two CETP polymorphisms and a three-locus haplotype raise coronary artery disease risk in a Polish population (Mol Biol Rep 2018)
- Dietary fat intake modifies how CETP variant rs5882 affects HDL cholesterol and blood pressure risk (Iran J Basic Med Sci 2018)
- CETP markers show strong associations with HDL cholesterol across obesity phenotypes in an Iranian cohort, unlike most FTO variants (Eat Weight Disord 2020)
- CETP variant rs1800777 is linked to greater fat mass, central obesity, and lower HDL cholesterol in obese adults (Endocrinol Diabetes Nutr 2018)
- Meta-analysis identifies two CETP variants among the leading genetic risk factors for polypoidal choroidal vasculopathy in Asians (J Ophthalmol 2018)
- In 1,264 Lithuanians, two CETP variants raise exudative AMD risk up to 1.7-fold while a third, rs3764261, cuts it by 1.8-fold (Gene 2017)
- Nat Rev Cardiol: most genetic variants that raise HDL-C don't lower cardiovascular risk, but CETP variants are a notable exception (Nat Rev Cardiol 2018)
- CETP variant rs3764261 is one of four risk alleles linked to lower HDL cholesterol in pregnant Chinese women (Oncotarget 2017)
- A protective CETP haplotype, but not individual TaqIB or D442G variants, lowers essential hypertension risk in Chinese Mongolians (Turk J Med Sci 2017)
- Meta-analysis links the CETP C-629A polymorphism to higher coronary heart disease risk and circulating CETP in Caucasians (Oncotarget 2017)
- Systematic review of 23 studies finds the CETP B1 risk allele responds better to dietary interventions than B2B2 (Nutr Metab 2017)
- CETP variant rs1800775 is associated with HDL cholesterol and total cholesterol, but not LDL, in pregnant Chinese women (J Clin Lipidol 2017)
- Total fat intake modifies the CETP Taq1B link to HDL cholesterol only in type 2 diabetes patients without dyslipidemia (Clin Nutr 2018)
- Rare CETP coding variants linked to age-related macular degeneration risk in a Japanese population study (Hum Mol Genet 2016)
- CETP Taq1B is linked to glycated hemoglobin levels in hyperlipidemic patients with diabetes, a link modulated by an LIPG variant (Can J Diabetes 2016)
- Plasma CETP is higher in metabolic syndrome, but the Taq1B genotype itself shows no direct link to the syndrome in Iranian subjects (Biochem Genet 2016)
- CETP I405V shows no link to age or cardiovascular disease despite raising HDL cholesterol (BMC Geriatr 2016)
- CETP TaqIB, but not apo AI 75G/A, significantly shapes HDL cholesterol levels in Polish men and women (Arch Med Sci 2016)
- Higher serum CETP levels and the -629A allele are linked to angiographically confirmed coronary atherosclerosis (Indian J Clin Biochem 2017)
- CETP c.*84G>A variant doubles coronary artery disease risk in South Indian patients (PLoS One 2016)
- Eight CETP gene polymorphisms show distinct HDL, LDL, and triglyceride associations in Kazak and Uyghur adults from Western China (Int J Environ Res Public Health 2015)
- CETP is among the genes most strongly linked to lipid change over time and incident hyperlipidemia in a large Chinese cohort study (Circ Cardiovasc Genet 2016)
- Meta-analysis links CETP rs3764261 variant to higher age-related macular degeneration risk across ethnicities (Sci Rep 2015)
- CETP variant rs708272 nearly doubles metabolic syndrome risk in women from southwestern Mexico (Int J Mol Sci 2015)
- CETP variant rs3764261 raises HDL cholesterol but does not affect diabetes risk or recurrent cardiovascular events in vascular disease patients (Atherosclerosis 2015)
- CETP I405V II genotype linked to gray matter diffusion abnormalities in healthy older adults (J Neural Transm 2015)
- CETP variant rs5882 determines whether plant sterol consumption lowers triglycerides, crossover trial finds (Appl Physiol Nutr Metab 2015)
- Novel CETP microdeletion lowers enzyme activity and raises HDL-associated cholesterol in three carriers (Clin Genet 2016)
- CETP variant rs708272 is one of three protective polymorphisms shielding HIV patients on antiretroviral therapy from atherogenic dyslipidemia (AIDS Res Hum Retroviruses 2015)
- Review proposes historic hepatic schistosomiasis as a screening factor behind East Asia's unusually high rate of genetic CETP deficiency (Nutrients 2015)
- CETP variant rs5882 G allele is linked to lower HDL cholesterol in obese and non-obese individuals alike (Gene 2015)
- The CETP locus is one of only three individually significant lipid-associated SNPs confirmed in a first Algerian population genetics study (Int J Clin Exp Pathol 2015)
- CETP variants A373P and Taq1 have opposite effects on low HDL cholesterol risk in Iranian children and teenagers (Atherosclerosis 2014)
- CETP TaqIB B2 allele carriers have higher HDL cholesterol and antioxidant enzyme activity in both healthy and diabetic Argentinians (J Diabetes Investig 2015)
- CETP is one of five gene loci with pleiotropic effects across metabolic syndrome components in over 15,000 African Americans (Circ Cardiovasc Genet 2014)
- CETP TaqIB B2B2 genotype is linked to more favorable HDL cholesterol levels in West Siberian Caucasians (Bull Exp Biol Med 2014)
- CETP I405V Val/Val genotype significantly determines HDL cholesterol levels in myocardial infarction patients (J Clin Diagn Res 2014)
- Meta-analysis finds CETP TaqIB genotype raises Alzheimer's risk only in APOE4-positive Asians, with no overall population association (Neurobiol Aging 2014)
- CETP TaqIB mutation carriers with low HDL cholesterol have a fivefold higher risk of premature coronary artery disease in Egyptians (J Clin Lipidol 2014)
- CETP variant rs708272 lowers coronary atherosclerosis risk while a linked variant shapes HDL cholesterol in Chinese healthy controls (Lipids Health Dis 2013)
- CETP gene promoter variants show no association with longevity in two Han Chinese samples (Mol Biol Rep 2013)
- A Filipino GWAS finds suggestive CETP and TOM1 associations with HDL cholesterol and allelic heterogeneity at the CETP locus (J Lipid Res 2013)
- CETP variant rs3764261 raises the risk of polypoidal choroidal vasculopathy in a Japanese population (Invest Ophthalmol Vis Sci 2013)
- CETP variant rs708272 associates with HDL-C and LDL-C levels in 365 Turkish children (OMICS 2013)
- Absence of the CETP B2 allele doubles coronary artery disease risk, but only in ethnic Chinese Singaporeans (Lipids Health Dis 2013)
- CETP gene promoter methylation correlates with LDL-C, HDL-C, and HDL particle size in familial hypercholesterolaemia patients (Atherosclerosis 2013)
- CETP rs3764261 T allele is the top single-locus HDL-C predictor among 13 SNPs in a 3,050-person Japanese cohort (PLoS One 2013)
- The CETP locus reaches genome-wide significance for baseline Lp-PLA2 mass in a JUPITER-trial GWAS of 6,851 statin-treated participants (Circ Cardiovasc Genet 2012)
- CETP I405V is linked to lower small dense LDL levels, unrelated to coronary artery disease risk, in Indian subjects (Indian J Clin Biochem 2012)
- Meta-analysis confirms CETP TaqIB polymorphism is linked to coronary artery disease in Chinese patients (J Zhejiang Univ Sci B 2012)
- CETP TaqIB genotype tracks with HDL-C differently in long-lived versus younger Chinese Bama Zhuang adults (Lipids Health Dis 2012)
- GWAS replication confirms CETP rs3764261 association with HDL-C in a 3,781-person Asian Indian cohort (PLoS One 2012)
- Three novel CETP gene mutations identified in Japanese patients with hyperalphalipoproteinemia (Clin Chim Acta 2012)
- CETP is one of only two loci genome-wide-significantly associated with Lp-PLA2 mass in a five-study CHARGE Consortium meta-analysis (Eur Heart J 2011)
- Review explains why CETP inhibition raises HDL2 cholesterol without necessarily improving reverse cholesterol transport (Biochim Biophys Acta 2011)
- CETP TaqIB polymorphism flags high coronary risk but cannot distinguish left main from more peripheral disease (Lipids Health Dis 2011)
- Unlike LCAT or ABCA1 mutations, heterozygous CETP mutations leave plasma sphingosine-1-phosphate and apoM levels unaffected (Atherosclerosis 2011)
- Systematic review confirms the CETP Taq-1B minor allele is protective against metabolic syndrome, among only eight genetic associations that hold up (Obes Rev 2011)
- CETP B1 allele raises coronary artery disease and diabetes risk independent of HDL-C in western Iran (Genet Test Mol Biomarkers 2011)
- Large AMD meta-analysis discovers two new genetic loci and confirms CETP among ten previously known susceptibility genes (Hum Mol Genet 2011)
- The PAGE study fails to replicate CETP rs1864163's HDL-C association across roughly 38,000 diverse-ancestry adults despite adequate power (PLoS Genet 2011)
- Combining CETP B2B2 with an ABCA1 variant produces the largest HDL cholesterol gap seen in a Chinese cohort of nearly 1 mmol/L (Acta Cardiol 2011)
- CETP and hepatic lipase gene variants interact to raise carotid atherosclerosis risk in 1,549-person SAPHIR cohort (Atherosclerosis 2011)
- Dense candidate-gene genotyping confirms CETP among established HDL-C loci in a 7,857-person meta-analysis and reveals multiple independent signals at several loci (Circ Cardiovasc Genet 2011)
- Three CETP variants are among only six SNPs linked to HDL cholesterol in European adolescents, first shown in this age group (Atherosclerosis 2011)
- A well-powered study of CETP sequence variation finds no meaningful association with cognitive decline or dementia risk (Int J Mol Epidemiol Genet 2011)
- CETP Taq1B B1B1 genotype is more common in Egyptian metabolic syndrome patients and tracks with lower HDL cholesterol (Diabetes Metab Syndr 2011)
- CETP and LPL polymorphisms jointly predict cardiovascular risk in women with high HDL cholesterol and CRP (Atherosclerosis 2011)
- CETP variant rs5882 is the second-strongest of nine genetic hits for low HDL cholesterol and heart disease risk in a 60-gene screen (J Lipid Res 2010)
- CETP Taq1B B2B2 genotype is linked to the highest HDL cholesterol and lowest oxidative stress marker levels in Tehran adults (Lipids Health Dis 2010)
- CETP variant rs708272 improves diagnostic accuracy for identifying patients with active atherosclerosis (Swiss Med Wkly 2010)
- CETP TaqIB B2 allele more than doubles recurrent event risk in postinfarction patients with high HDL-C and CRP (Arterioscler Thromb Vasc Biol 2010)
- CETP is one of only four genes confirmed to affect HDL cholesterol, with no evidence its effect depends on alcohol intake (Atherosclerosis 2010)
- CETP TaqIB genotype distinguishes a longevity syndrome of simultaneously high HDL and LDL cholesterol (Open Cardiovasc Med J 2010)
- Olive-oil-enriched skim milk raises HDL cholesterol most in children with the CETP B1B1 genotype (Ann Nutr Metab 2010)
- Combined LIPC and CETP I405V variants double coronary artery disease risk, but the effect fades in women with high HDL cholesterol (Genet Test Mol Biomarkers 2009)
- CETP -629C>A promoter variant predicts HDL-C response to growth hormone only in glucocorticoid-treated patients (Eur J Endocrinol 2010)
- CETP TaqIB significantly shapes baseline HDL subpopulation profile in postmenopausal women, though hormone therapy response is largely unaffected (Clin Endocrinol 2010)
- CETP genotype tracks with HDL cholesterol and triglycerides but not with coronary artery disease risk in Turkish angiography patients (Eurasian J Med 2009)
- CETP -629C/A AA genotype raises HDL cholesterol but may still carry higher coronary artery disease risk in Iranian Azeris (Iran Biomed J 2009)
- CETP-HDL association is one of only four gene-lipid-trait pairs replicated using a new cardiovascular gene chip in a multiethnic cohort (J Lipid Res 2009)
- CETP I405V VV genotype is linked to higher HDL cholesterol in Turks, an effect modified by sex and triglycerides (Cell Biochem Funct 2009)
- CETP variant A373P is independently linked to lower HDL cholesterol and ApoA-I-containing lipoproteins, largely independent of other tested genes (Metabolism 2009)
- CETP activity is markedly elevated in Iranian patients with primary combined hyperlipidaemia, modulated by Taq1B genotype (Indian J Med Res 2009)
- CETP I405V V-allele carriers lose more ApoA-I and HDL cholesterol when switched from a high to low polyunsaturated fat diet (Horm Metab Res 2009)
- CETP B1B1 genotype nearly triples coronary heart disease risk in a South Indian population (Clin Chim Acta 2009)
- A CETP gene variant favors healthy survival past age 90 in long-lived Japanese-American men (J Gerontol A Biol Sci Med Sci 2008)
- CETP B1 allele raises metabolic syndrome risk specifically in Turkish women, large cross-sectional study finds (Anadolu Kardiyol Derg 2008)
- CETP Taq1B B2 allele cuts coronary stenosis risk by 18 percent overall, and 38 percent in male nonsmokers, in Tunisians (Arch Cardiovasc Dis 2008)
- CETP TaqIB predicts HDL cholesterol in one Chinese ethnic minority but not in neighboring Han Chinese (J Investig Med 2008)
- CETP genetic variants are linked to plasma vitamin E levels, extending CETP genetics beyond cholesterol transport (Br J Nutr 2009)
- Two CETP variants are among only seven SNPs confirmed to affect HDL cholesterol in a 384-SNP, 251-gene screen (J Lipid Res 2008)
- CETP variants shape cerebral and peripheral cholesterol metabolism but not Alzheimer's disease risk (Brain Res 2008)
- CETP gene is the only lipid-metabolism gene whose HDL-C association shifts with menopause in the ARIC Study (Atherosclerosis 2008)
- CETP B1B1 genotype is nearly twice as common in Taiwanese people with a parental history of cardiovascular disease (Med Princ Pract 2008)
- CETP activity is significantly elevated in Iranian patients with primary hypertriglyceridemia, and modulated by Taq1B genotype (Pak J Biol Sci 2007)
- CETP I405V fails to replicate as a longevity gene in a large American Caucasian cohort (Biogerontology 2007)
- CETP I405V I-allele carriers respond better to simvastatin, with greater triglyceride and HDL cholesterol improvement (Expert Opin Pharmacother 2007)
- The favorable CETP-VV genotype is found to buffer the deleterious effect of the lipoprotein(a) gene in exceptionally long-lived Ashkenazi Jews (PLoS Comput Biol 2007)
- CETP -629C>A genotype effect on HDL cholesterol is only partly explained by its impact on cholesteryl ester transfer activity (Scand J Clin Lab Invest 2008)
- CETP variants replicate their known HDL cholesterol association in renal transplant patients, but do not predict fluvastatin response (J Lipid Res 2007)
- CETP B1B1 genotype triples coronary artery disease risk in Taiwanese patients with type 2 diabetes (Metabolism 2007)
- CETP genotype shows no association with cognitive function or lifetime cognitive change in the Scottish Mental Survey cohort (Neurosci Lett 2007)
- CETP TaqIB B2 allele blunts the post-meal fat spike in patients with familial hypercholesterolemia (Clin Chem Lab Med 2007)
- CETP promoter -1337 CC genotype doubles coronary atherosclerosis risk in Japanese familial hypercholesterolaemia patients (Clin Sci 2006)
- Two novel CETP nonsense mutations produce complete deficiency without coronary disease in a Greek pedigree (J Mol Med 2006)
- CETP I405V homozygotes for the I allele have significantly less severe coronary artery narrowing (Clin Invest Med 2006)
- CETP I405V VV genotype is twice as common in people over 89 as in young adults, and linked to fewer vascular events (Arch Gerontol Geriatr 2006)
- CETP genotype fails to predict LDL cholesterol response to dietary fat, contradicting earlier studies (Nutr Metab Cardiovasc Dis 2005)
- Case report finds significant coronary stenosis in a woman with CETP deficiency and HDL-C of 209 mg/dL (Circ J 2005)
- CETP activity rises with the number of diseased coronary vessels in Tunisian type 2 diabetics (Clin Biochem 2005)
- Carotid imaging shows CETP loss-of-function carriers, unlike apoA-I or ABCA1 mutation carriers, have unaltered atherosclerosis progression (Curr Opin Lipidol 2005)
- Two independent cohorts find no genetic association between CETP polymorphisms and late-onset Alzheimer's disease (Neurosci Lett 2005)
- CETP B2B2 genotype is more common in diabetics but less common after a heart attack, suggesting a role in identifying diabetic risk (Atherosclerosis 2005)
- CETP I405V and healthy aging link does not replicate in Italian centenarians (Mech Ageing Dev 2005)
- Review surveys CETP as a pivotal HDL-raising drug target as human CETP inhibitor data become available (J Lipid Res 2004)
- A highly variable repeat in the CETP promoter forms unusual DNA structures and predicts HDL-C levels (Biochim Biophys Acta 2004)
- Review confirms CETP promoter variant -629 C to A, not TaqIB, drives CETP activity, and finds no TaqIB-pravastatin pharmacogenetic interaction (Curr Opin Lipidol 2004)
- Daily exercise raises HDL cholesterol most in men with the CETP B1B1 genotype (Clin Genet 2004)
- Combined CETP and ApoA-I genotypes span a 0.54 mmol/L range in HDL-C among Japanese women (Nutr Metab Cardiovasc Dis 2004)
- Review positions CETP as a new therapeutic target, noting statins and fibrates already attenuate its activity indirectly (Pharmacol Ther 2004)
- Review examines conflicting evidence on CETP genetic variation and longevity in centenarians (J Atheroscler Thromb 2004)
- CETP activity rises 50% in one ABCA1-heterozygote kindred but not three others, alongside severe HDL abnormalities (Atherosclerosis 2003)
- CETP TaqI B polymorphism only modestly raises HDL cholesterol in Saudis, too small an effect to explain their low HDL levels (Clin Sci 2003)
- The largest study of its kind finds CETP gene variants are not useful markers for predicting restenosis after angioplasty (J Thromb Haemost 2003)
- Mice and rats lack functional CETP due to a shared ancestral nonsense mutation, not altered regulation (Comp Biochem Physiol B 2003)
- Review argues the time is right to test CETP inhibition in randomized human atherosclerosis trials (Arterioscler Thromb Vasc Biol 2003)
- CETP deficiency raises HDL cholesterol in Japanese centenarians but does not affect longevity (J Mol Med (Berl) 2003)
- CETP Taq1B genotype only predicts HDL cholesterol in obese women with low fasting insulin (Atherosclerosis 2002)
- CETP I405V, not Taq1B, predicts smaller LDL particle size in Japanese patients (Atherosclerosis 2002)
- CETP levels are elevated in Chinese heart attack and stroke patients, while CETP-deficient carriers show a favorable lipid profile despite low CETP mass (Chin Med J 2002)
- CETP TaqI B2 allele raises HDL cholesterol more strongly in men than women in a rural Japanese population (J Epidemiol 2002)
- The first CETP TaqI genotyping in Egyptians finds a B1:B2 allele split of 0.65:0.35, matching the pattern shared by other Arab-descended populations (Eur J Clin Pharmacol 2002)
- CETP TaqIB B2B2 genotype protects against atherosclerosis only when it actually lowers CETP mass, angiography-based Japanese study finds (Atherosclerosis 2001)
- CETP TaqIB does not predict angiographically documented coronary artery disease risk, large case-control study finds (Clin Genet 2001)
- A dominant-negative CETP promoter mutation cuts transcriptional activity to 8% of wild type in Japanese hyperalphalipoproteinemia (ATVB 2001)
- CETP TaqIB genotype linked to macroangiopathy risk in Japanese patients with type 2 diabetes (Atherosclerosis 2001)
- CETP TaqIB genotype shows no link to diabetic kidney disease severity in a large type 1 diabetes cohort (Nephrol Dial Transplant 2000)
- A lower CETP B2 allele frequency in Valencia may help explain the unexpectedly high heart disease rate in the region (Atherosclerosis 2000)
- CETP mass and activity rise significantly after a meal, with the Taq 1B polymorphism predicting who has the lowest levels (Br J Nutr 2000)
- CETP TaqIB genotype explains major HDL cholesterol differences in renal transplant patients, but only in those without abdominal obesity (Nephron 2000)
- C/EBP-beta binds the CETP gene promoter in liver cells but does not actually drive CETP expression (Atherosclerosis 1999)
- CETP D442G mutation more than doubles vascular disease prevalence in dialysis patients, but only when HDL cholesterol is already low (Kidney Int Suppl 1999)
- A cholesterol response element in the CETP promoter explains why CETP rises, not falls, with cholesterol loading (J Lipid Res 1999)
- CETP mutation G1533A raises transfer activity and lowers HDL cholesterol, tested with a new simplified assay (Clin Chem Lab Med 1998)
- CETP B2 allele raises HDL cholesterol in diabetic men, but moderate alcohol intake shows no benefit unlike in non-diabetics (Scand J Clin Lab Invest 1998)
- A rare CETP intron 14 mutation, usually found only in Japanese, is identified in a Finnish family with high HDL cholesterol (Arterioscler Thromb Vasc Biol 1998)
- A new simple sandwich immunoassay for CETP mass correctly detects genetic CETP deficiency in human serum (Clin Chim Acta 1998)
- CETP Taq1B genotype predicts HDL cholesterol in diabetic patients independent of measured CETP concentration (J Lipid Res 1998)
- A CETP mutation previously reported only once is surprisingly common in North Americans with high HDL cholesterol (Clin Biochem 1997)
- A novel intron 10 splice mutation causes exon 10 skipping and disrupts downstream splicing in CETP deficiency (J Lipid Res 1996)
- A newly found CETP 3-prime-UTR variant lowers CETP activity by nearly 30 percent, replicated in two independent samples (Atherosclerosis 1996)
- CETP deficiency enlarges apoA-I lipoprotein particles and impairs their cholesterol-handling function (J Lipid Res 1995)
- CETP transgenic mice develop more severe, faster-progressing fatty liver than controls, worse in males (Biochem Biophys Res Commun 1994)
- Enlarged HDL2 from CETP-deficient patients fails to protect macrophages from cholesterol accumulation (J Biochem 1994)
- Intron 14 CETP splicing defect is found in 3.5% of Japanese patients with marked hyperalphalipoproteinemia and an estimated 1/42,000 homozygote frequency (Atherosclerosis 1993)
- A rapid NdeI-based PCR screen finds the intron 14 CETP splicing defect in 21 of 121 Japanese patients with hyperalphalipoproteinemia (Hum Genet 1993)
- CETP and apoA-I gene polymorphisms show no association with coronary heart disease in a Sri Lankan population, though the CETP B1 allele tracks with lower HDL cholesterol (Atherosclerosis 1990)
- CETP variants rs2033254 and rs12708980 associate with lower intestinal cholesterol absorption markers in a European GWAS (Nutrients 2026)
- Taiwan Biobank GWAS of 40,773 people finds a three-way APOA5-LPL-CETP gene interaction behind metabolic syndrome susceptibility (Genome Biol 2026)
- Splice-site CETP mutations are found in 10% of a South Indian familial hypercholesterolemia cohort (Cureus 2025)
- Machine learning flags CETP as an immune biomarker for diabetes-tuberculosis comorbidity, AUC 0.804 (Microorganisms 2025)
- Mendelian randomisation study finds no genetic link between CETP-mediated LDL-C and pulmonary vascular disease, unlike NPC1L1 and PCSK9 (Pulm Circ 2025)
- Mendelian randomisation study centred on HMGCR also finds CETP-mediated LDL-C consistently associated with lower aortic aneurysm risk (Nutr Metab 2024)
- CETP TaqIB genotype shows no association with the effect of dulaglutide on HbA1c or hepatic steatosis, unlike PNPLA3 (Endocrine 2024)
- CETP variant rs5817082 is individually linked to extramacular drusen independent of overall AMD genetic risk (Invest Ophthalmol Vis Sci 2024)
- The CETP rs708272 AA genotype is linked to higher HDL cholesterol in an Iranian coronary artery disease cohort (J Clin Lab Anal 2024)
- CETP variant rs708272 emerges as a candidate screening marker for type 2 diabetes risk in Filipinos, genomic study finds (PLoS One 2024)
- First Mendelian randomisation of lipid drug targets and diabetic retinopathy finds a PCSK9 signal but no CETP association (J Lipids 2024)
- A CETP variant predicts who loses the most weight with a digital lifestyle-modification program (Sci Rep 2023)
- Dietary antioxidant intake does not interact with the CETP Taq1B polymorphism to affect lipid profile or coronary stenosis severity (Food Sci Nutr 2024)
- Whole-genome sequencing of unexplained severe familial hypercholesterolaemia turns up a novel CETP deletion variant (Vavilovskii Zhurnal Genet Selektsii 2023)
- Targeted sequencing finds low-HDL-linked variants in CETP and three other genes in one in six people with metabolic syndrome (Diabetol Metab Syndr 2022)
- Systematic review names CETP-TaqIB as one of the most consistently studied gene-diet interactions in cardiovascular disease research (BMC Cardiovasc Disord 2022)
- Iranian case-control study finds no direct link between CETP polymorphism rs708272 and coronary artery disease, but flags a CETP-activity/HDL-C interaction (BMC Cardiovasc Disord 2022)
- CETP genetic variants predict baseline LDL cholesterol but not atorvastatin response in Jordanian patients (Drug Metab Pers Ther 2022)
- CETP variant rs1532624 is among the five most prevalent clinically relevant pharmacogenomic markers found in Pakistani ethnic groups (Evol Bioinform Online 2022)
- Atorvastatin exposure is about twice as high in healthy Korean volunteers as in Caucasians, partly explained by eight variants including one in CETP (Front Genet 2022)
- An ABCG1 gene variant is linked to higher CETP activity in a Brazilian population study (Biochem Genet 2022)
- GWAS of 49,915 Koreans finds CETP among the lipid genes shared by metabolically unhealthy normal-weight and obese phenotypes (Sci Rep 2021)
- eMERGE Network study fails to replicate the CETP-triglyceride association found in prior smaller studies (BMC Med Genomics 2021)
- Review names the CETP TaqIB polymorphism as one of three gene variants that heighten cardiovascular risk in heavy drinkers (Curr Neurovasc Res 2021)
- Gut metabolite TMAO shows no link to genetically determined CETP levels in coronary artery disease patients (Sci Rep 2020)
- In a north Indian CAD study, CETP rs708272 alone was not significant, but showed a synergistic interaction with physical inactivity (BMC Cardiovasc Disord 2020)
- CETP variant rs708272 ranks among the top ten SNPs in a 24-gene model predicting childhood and adolescent obesity, alongside diet and gut microbiota (Sci Rep 2020)
- Genetically determined CETP concentration shows only a weak link to clotting factor VII and no link to venous thrombosis risk (J Thromb Haemost 2019)
- CETP rs5883 polymorphism does not distinguish coronary artery disease patients from controls in a Turkish cohort (In Vivo 2019)
- CETP inhibitors do not appear to raise new-onset diabetes risk unlike LDL-receptor-acting drugs (J Cardiovasc Pharmacol Ther 2018)
- CETP TaqIB variant is linked to diabetic retinopathy incidence over nine years, though HbA1c and triglycerides prove the stronger predictors (Diabetes Res Clin Pract 2017)
- CETP TaqIB genotype shapes how herbal tea affects HDL cholesterol and triglycerides in hypercholesterolemic patients (Asia Pac J Clin Nutr 2017)
- CETP gene variants are associated with neuropsychiatric symptom severity in Alzheimer's disease (Braz J Psychiatry 2017)
- CETP gene variants linked to memory loss risk in a rural and tribal Indian cohort study (J Alzheimers Dis 2017)
- Review highlights ADCY9 pharmacogenomics as a model for rescuing dalcetrapib and future lipid trials (Curr Opin Lipidol 2016)
- CETP variant rs820299 nominally associates with metabolic syndrome and interacts with lifestyle factors in a Taiwanese replication study (Sci Rep 2016)
- Whole-body model finds high-activity CETP genotypes raise LDL-C more with ageing than low-activity genotypes (Biosystems 2016)
- A genome-wide meta-analysis in Hispanic populations confirms CETP as a genome-wide-significant locus for HDL cholesterol (Sci Rep 2016)
- CETP I405V variant shows no association with premature coronary artery disease presence or severity in Iranian patients (Bosn J Basic Med Sci 2016)
- Review highlights zebrafish, which retain a cetp ortholog, as an emerging model for dyslipidaemia research (Front Endocrinol (Lausanne) 2016)
- CETP variant rs5882 shows no association with LDL cholesterol lowering from plant sterols, unlike CYP7A1 and APOE variants (Am J Clin Nutr 2015)
- CETP G allele carriers show distinct waist circumference and metabolic profiles, independent of glucose and lipid changes (Diabetes Res Clin Pract 2014)
- Review argues CETP inhibitor failures show over-reliance on HDL cholesterol as an efficacy marker (Clin Lipidol 2013)
- Two CETP variants are among only eight significant HDL predictors identified across 65 SNPs and 23 candidate genes (Lipids Health Dis 2013)
- A CETP variant is among four SNPs significantly linked to plasma cholesterol, though only APOB and NPC1L1 show novel diet-gene interactions (J Lipid Res 2013)
- CETP genotype frequencies do not differ between centenarians, nonagenarians, and average-lifespan controls (Angiology 2013)
- CETP variant rs17231506 is one of five genes shaping sex-specific cholesterol efflux capacity independent of HDL-C (Arterioscler Thromb Vasc Biol 2013)
- Baseline CETP activity nearly doubles in carriers of the eNOS T-786C polymorphism, atorvastatin crossover study finds (Arq Bras Cardiol 2013)
- CETP TaqIB genotype raises HDL cholesterol but does not predict Alzheimer's disease risk in a Han Chinese cohort (Lipids Health Dis 2012)
- CETP I405V and Taq1B polymorphisms show inconsistent links to subclinical carotid atherosclerosis in Brazilians (Lipids Health Dis 2012)
- CETP variant rs5882 is one of only four significant SNP predictors of plasma homocysteine among 64 tested in healthy adults (J Nutr 2012)
- Annual exercise-genomics review highlights physical activity modifying how CETP and two other genes affect HDL cholesterol (Med Sci Sports Exerc 2012)
- NMR fine-mapping finds CETP among only four loci linked to bulk serum lipids, versus eight linked to lipoprotein subfractions (Hum Mol Genet 2012)
- CETP Taq1B polymorphism shows no effect on HDL cholesterol or coronary artery disease risk in a Turkish angiography cohort (Genet Test Mol Biomarkers 2010)
- Review links apoB signal-peptide and CETP B1B1 combination to lower VLDL apoB secretion in obese men (Curr Opin Lipidol 2010)
- CETP TaqIB polymorphism does not predict coronary restenosis after angioplasty and stenting (Angiology 2010)
- CETP -629C>A polymorphism is not among the genetic determinants of coronary artery disease in Turks despite its HDL cholesterol effect (Cell Biochem Funct 2009)
- CETP TaqIB and I405V polymorphisms show sex-specific effects on postprandial triglycerides in familial hypercholesterolaemia (Lipids Health Dis 2009)
- CETP TaqIB variant, unlike APOE4, shows no link to obesity or blood pressure in North Indian subjects (Mol Cell Biochem 2008)
- The CETP D442G variant shows a preliminary protective association against Alzheimer's disease in Chinese APOE4 carriers (Brain Res 2008)
- Review concludes the link between CETP and atherosclerosis risk depends on gene-environment interaction, unlike the direct effects of APOA1 and ABCA1 (Curr Opin Lipidol 2007)
- Unlike hepatic lipase and LPL variants, the CETP-HDL cholesterol link is not modified by dietary fat intake in a large biracial cohort (Atherosclerosis 2007)
- Mapping the CETP gene reveals seven distinct linkage blocks and yields an optimal set of eleven tagging SNPs for future association studies (Ann Hum Genet 2006)
- Combining three CETP polymorphisms predicts lipid profile better than any single variant in South Indians (Clin Chim Acta 2007)
- CETP TaqIB genotype link to HDL-C is stronger in alcohol drinkers than non-drinkers (Atherosclerosis 2007)
- Review states the once-promising CETP Taq-I to statin-response link has now been disproved (Vascul Pharmacol 2006)
- CETP TaqIB genotype shows no link to plaque composition or neointima after carotid endarterectomy, unlike hepatic lipase variant (Atherosclerosis 2005)
- Large pharmacogenetic screen finds CETP-HDL response to pravastatin too weak to qualify, unlike the dominant HMG-CoA reductase signal (JAMA 2004)
- CETP Taq1B B2B2 genotype linked to low HDL cholesterol in Turkish type 2 diabetic patients (Int J Mol Med 2004)
- CETP TaqI B genotype shows no association with late-onset Alzheimer's disease or interaction with APOE4 or lipoprotein lipase (Neurosci Lett 2004)
- CETP TaqIB genotype shows no link to preeclampsia or pregnancy lipid profile, unlike apoE (Eur J Obstet Gynecol Reprod Biol 2004)
- The effect of CETP genotype on HDL cholesterol is unaffected by physical activity level in a population-based Swiss cohort (Med Sci Sports Exerc 2003)
- New statistical method for analyzing gene haplotypes is validated using CETP variants and HDL cholesterol data from the REGRESS trial (Ann Hum Genet 2003)
- A newly mapped major gene, not CETP or five other known HDL genes, controls large HDL particle levels in baboons (Atherosclerosis 2002)
- Genetic CETP deficiency nearly doubles plasma PLTP concentration by accumulating its inactive form (J Lipid Res 2002)
- CETP genotype, like four other candidate genes, fails to predict cholesterol response to plant stanol esters (Eur J Clin Invest 2002)
- Novel splice-site mutation in the CETP gene found in a patient with hyperalphalipoproteinemia (Metabolism 2002)
- CETP promoter and intron 1 SNPs form haplotypes linked to HDL and LDL cholesterol, with sex-dependent strength (Hum Hered 2002)
- CETP D442G and TaqIB variants track with higher HDL cholesterol in Taiwanese Chinese, but the link weakens with obesity (Hum Genet 2001)
- Heterozygous CETP D442G carrier shows apolipoprotein E trapped in HDL at triple the level of other carriers (Clin Chim Acta 2000)
- CETP I405V genotype, unlike apoB EcoRI variation, does not predict cholesterol response to diet in an Israeli cohort (Atherosclerosis 2000)
- A retinoic acid receptor element is identified in the human CETP gene promoter (Biochem Biophys Res Commun 1999)
- Probucol regresses established aortic plaques in hyperlipidemic rabbits and significantly raises CETP activity, likely via antioxidant action (Atherosclerosis 1998)
- ApoA-IV 360His variant, not CETP or LCAT activity, explains why some people respond more to dietary fat changes (J Lipid Res 1997)
- CETP gene screening finds no significant link to abdominal aortic aneurysm, ruling it out as a candidate gene (Clin Genet 1997)
- CETP D442G mutation is found in two families with Lowe syndrome and elevated HDL cholesterol (Acta Paediatr 1997)
- The ApoA-IHelsinki mutation lowers HDL cholesterol and cuts CETP activity by 25% in a Finnish kindred (ATVB 1995)
- A silver-stained PCR-SSCP assay rapidly detects the intron 14 CETP-deficiency mutation without radioactivity (Clin Chem 1994)
- A family study traces complete CETP deficiency to an intron 14 splicing defect found on a routine health check (Intern Med 1994)
- CETP TaqI RFLP frequencies are remarkably uniform across Italian, Greek, and other Caucasian populations (Hum Hered 1994)
- Rabbit liver's nonparenchymal cells express more CETP mRNA than the parenchymal cells that dominate most other lipid genes (J Lipid Res 1993)
- A PCR-based site-directed mutagenesis method detects one CETP-deficiency homozygote and three heterozygotes among 554 Japanese subjects (Biochim Biophys Acta 1993)
- CETP Taq1B polymorphism shows no association with cardiovascular risk factors or angiographic severity in Iranian angiography patients (Iran J Med Sci 2024)
- A systematic review finds no clear link between CETP genetic variation and intestinal cholesterol absorption (Prog Lipid Res 2022)
- CETP genotype does not modify how DHA supplementation lowers triglycerides, randomized feeding trial finds (Lipids 2018)
- CETP TaqIB polymorphism shows no link to metabolic syndrome in Southern Thai subjects (Biochem Genet 2015)
- Review names CETP as one of only two candidate genes for lipid response to exercise training, despite roughly 100 inconsistent studies (J Appl Physiol 2011)
- CETP TaqIB and LPL Ser447Ter polymorphisms show no association with ischaemic stroke in Greek patients (Neurosci Lett 2005)
- Novel LCAT mutation in a Polish family leaves CETP activity at the low end of normal (Atherosclerosis 2006)
- Lymphocyte gene expression profiling finds CETP expression unaltered in Alzheimer's disease patients (Psychiatr Genet 2005)
- A hidden CETP gene variant caused false positives in fluorescence-based TaqIB genotyping (Clin Chem 2001)
- CETP TaqIB polymorphism proves noninformative for apo B levels linked to parental heart-attack history (Atherosclerosis 2001)
- A young man with familial hypercholesterolaemia is found to also carry heterozygous CETP deficiency (Intern Med 1998)
- An apoA-I promoter variant does not affect HDL cholesterol regardless of CETP deficiency status in Japanese subjects (Hum Genet 1995)