The class
Polyacetylene compounds isolated from Korean ginseng roots inhibit human CETP (Chem Pharm Bull (Tokyo) 1996)
Original title: Isolation of cholesteryl ester transfer protein inhibitors from Panax ginseng roots
Researchers isolated CETP inhibitors from the extract of Korean Panax ginseng C. A. Meyer roots and identified them structurally as polyacetylene analogs. These natural compounds inhibited human CETP with IC50 values of around 20 to 35 mg/mL, adding ginseng-derived polyacetylenes to the catalog of plant natural products with CETP-inhibitory activity, albeit at relatively weak mass-based potency compared with purified small-molecule leads.
Original abstract
We have isolated cholesteryl ester transfer protein (CETP) inhibitors from the extract of Korean Panax ginseng C. A. Meyer roots and identified them as polyacetylene analogs. These compounds inhibit human CETP with IC50 values of around 20-35 mg/ml.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.