The class
Hepatic CETP secretion rises with dietary cholesterol in a dose-dependent, strain-independent manner in rabbits (Comp Biochem Physiol B Biochem Mol Biol 1996)
Original title: CETP activity in liver perfusates and plasma from rabbits hypo- or hyperresponsive to dietary cholesterol
Comparing two inbred rabbit strains that differ markedly in hypercholesterolemic response to dietary cholesterol, researchers found that a 0.3% cholesterol diet raised plasma and liver cholesterol more in hyperresponders than hyporesponders (by 15 mM and 30 micromol/g respectively) and roughly doubled hepatic CETP secretion in both strains equally. A lower, 0.08% cholesterol diet also produced a larger cholesterolemic and hepatocholesterolic response in hyperresponders, but did not increase hepatic CETP secretion in either strain, and cholesterol feeding at the higher dose raised plasma CETP activity by 90% in both strains without strain differences. The data suggest hepatic CETP secretion rises with plasma cholesterol in a parabolic, dose-dependent manner that is independent of the genetic hypo/hyperresponder distinction.
Original abstract
We investigated the relationship between the development of hypercholesterolemia in rabbits and cholesteryl ester transfer protein (CETP) activity secretion by their perfused livers. Two inbred strains of rabbits were compared which differ markedly in their hypercholesterolemic response to dietary cholesterol. Feeding a high-cholesterol (0.3%) diet, increased plasma and liver cholesterol level in the two strains, the increments being 15 mM and 30 mumol/g greater in the hyperresponders, respectively. The high-cholesterol diet caused an about 2-fold increased hepatic secretion of CETP activity, but there was no difference between the two rabbit strains. Feeding a lower amount of dietary cholesterol (0.08%) also caused higher cholesterolemic (2 mM) and hepatocholesterolic (28 mumol/g) responses in hyper- than in hyporesponsive rabbits. The activity of hepatic CETP secretion was not increased by the low-cholesterol diet, and there was no difference between hypo- and hyperresponsive rabbits. Cholesterol feeding increased plasma CETP activity by 90% in both rabbit strains, but there was no difference between the strains. Our combined data suggest that with increasing plasma cholesterol levels hepatic CETP secretion may be increased in a parabolic manner, reaching its maximum rate for before plasma cholesterol concentrations are maximal. There were no differences in hepatic CETP activity secretion of plasma CETP activity levels between the genetically different strains of hypo- and hyperresponsive rabbits.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.