Liver 66 items

Studies

• Eliminating liver Kupffer cells abolishes hepatic CETP expression and lowers plasma CETP, identifying their cellular origin for this protein (Hepatology 2015)Hepatology · August 2015 9
• C/EBP binds the CETP gene promoter and boosts its reporter-gene activity in liver cells, with C/EBP and CETP mRNA loss occurring in parallel in cultured hepatocytes (J Biol Chem 1992)J Biol Chem · November 1992 8
• Within three days, an atherogenic diet raises rabbit liver CETP mRNA 2.8-fold and plasma CETP mass 3.2-fold, while other liver mRNAs stay unchanged (J Clin Invest 1990)J Clin Invest · February 1990 8
• Liver-targeted CETP expression improves glucose tolerance in female mice but worsens it and drives fatty liver in males (bioRxiv 2026)bioRxiv · July 2026 8
• In female mice, CETP enables an estrogen-SHP pathway raising VLDL triglyceride production and, independently, an ERalpha pathway boosting liver fat oxidation (J Lipid Res 2016)J Lipid Res · June 2016 8
• Human CETP transgenic mice show higher survival and lower IL-6 after polymicrobial sepsis, linked to reduced macrophage TLR4 and NF-kB activation (Mediators Inflamm 2016)Mediators Inflamm · January 2016 8
• Inflammatory macrophages selectively lose the LXR-driven induction of CETP seen in noninflammatory cells, even as ABCA1 and ABCG1 induction persist (Arterioscler Thromb Vasc Biol 2009)Arterioscler Thromb Vasc Biol · August 2009 8
• CETP-derived peptide Seq-1 directly suppresses pro-fibrotic gene expression in liver cells beyond its role in the anti-CETP vaccine (Arch Med Res 2024)Arch Med Res · February 2024 7
• In obese CETP-transgenic mice, anacetrapib improved HDL function but drove fatty liver and insulin resistance, a clue to trials where two-thirds of patients were obese (Diabetes 2018)Diabetes · September 2018 7
• Baseline CETP level predicts how much pitavastatin lowers LDL-C, via LXR-dependent suppression of CETP transcription (Lipids Health Dis 2016)Lipids Health Dis · March 2016 7
• Bile-acid-activated farnesoid X receptor identified as a novel driver of CETP expression, explaining low HDL-C in cholestasis (J Lipid Res 2013)J Lipid Res · April 2013 7
• Two linked CETP SNPs more than double the odds of fatty liver in adolescent girls, independent of adiposity (J Gastroenterol Hepatol 2012)J Gastroenterol Hepatol · September 2012 7
• Niacin lowers plasma CETP mass 30% by reducing liver macrophage content, not by directly suppressing macrophage CETP expression (Biochem Pharmacol 2012)Biochem Pharmacol · June 2012 7
• LXRalpha, not LXRbeta, drives human CETP transcription, confirmed in monkeys, human-CETP-transgenic mice, and HepG2 cells (Atherosclerosis 2010)Atherosclerosis · April 2010 7
• FXRalpha suppresses CETP gene expression by competing with LXRalpha at a shared promoter element (Mol Cells 2008)Mol Cells · June 2008 7
• CETP directly delivers HDL cholesteryl ester to the liver independent of SR-BI and LDL receptor pathways (Biochim Biophys Acta 2006)Biochim Biophys Acta · September 2006 7
• ApoCI overexpression backfires as a CETP-blocking strategy by triggering compensatory CETP gene induction (Biochem J 2005)Biochem J · January 2005 7
• An Alu repeat represses and a CPF binding site activates the human CETP gene's distal promoter (J Lipid Res 2003)J Lipid Res · February 2003 7
• High plasma CETP does not speed reverse cholesterol transport in vivo despite raising liver cholesteryl ester uptake (Atherosclerosis 2002)Atherosclerosis · September 2002 7
• CETP genotype combined with apoB signal peptide variant is the strongest predictor of hepatic apoB-100 secretion in obese men (J Lipid Res 2000)J Lipid Res · March 2000 7
• Combined CETP and hepatic lipase deficiency drives atherosclerotic disease in some patients with marked high HDL (Arterioscler Thromb Vasc Biol 1995)Arterioscler Thromb Vasc Biol · November 1995 7
• Natural flanking sequences enable dietary cholesterol to boost human CETP gene transcription up to fivefold in transgenic mice (J Clin Invest 1992)J Clin Invest · October 1992 7
• CETP boosts Hep G2 cell uptake of HDL cholesteryl esters indirectly, via LDL receptor-mediated re-uptake of secreted lipoproteins, not directly (J Biol Chem 1989)J Biol Chem · April 1989 7
• Combined GIPR/GLP1R agonism additively lowers triglycerides, hepatic steatosis and Kupffer-cell-driven liver inflammation in CETP-humanised NAFLD mice (EBioMedicine 2023)EBioMedicine · June 2023 6
• CETP promotes triglyceride storage in liver and intestinal cells, unlike its fat-reducing effect in adipocytes (Lipids 2021)Lipids · December 2021 6
• Elafibranor reduces steatosis, hepatic inflammation and fibrosis progression in CETP-humanised NASH mice, with 87% pathway overlap to human NASH (Sci Rep 2021)Sci Rep · March 2021 6
• Neither a liraglutide RCT nor a 1,611-person cohort finds any link between liver fat content and circulating CETP, despite CETP's hepatic Kupffer-cell origin (Sci Rep 2019)Sci Rep · July 2019 6
• Metabolic liver inflammation in obesity does not clearly lower CETP, unlike bacterial-endotoxin activation of Kupffer cells (Atherosclerosis 2018)Atherosclerosis · June 2018 6
• CETP variant rs1800777 A allele linked to milder liver damage in fatty liver disease (Ann Nutr Metab 2018)Ann Nutr Metab · January 2018 6
• Active hepatitis C infection is associated with higher serum CETP and HDL triglyceride than after viral eradication (World J Hepatol 2016)World J Hepatol · February 2016 6
• Contrary to expectation, higher plasma TMAO from L-carnitine correlates with smaller aortic lesions in CETP-expressing ApoE-deficient mice (Atherosclerosis 2015)Atherosclerosis · November 2015 6
• CETP deficiency protects against fatal liver damage from schistosomiasis by starving parasite eggs of HDL cholesteryl ester (J Biomed Res 2015)J Biomed Res · April 2015 6
• Knocking down hepatic SR-BI raises CETP-mediated cholesteryl ester transfer from HDL to apoB lipoproteins and halves atherosclerotic lesion area in rabbits (Atherosclerosis 2012)Atherosclerosis · March 2012 6
• A four-week rimonabant intervention in CETP-humanised mice cuts body weight 9.4% and plasma cholesterol 24%, with systems-lipidomics revealing distinct plasma and liver lipid signatures (PLoS One 2011)PLoS One · January 2011 6
• CETP mutations raise HDL 27-hydroxycholesterol, and CETP mass correlates more strongly with 27OHC-ester than cholesteryl ester transfer (Atherosclerosis 2010)Atherosclerosis · November 2010 6
• Diet-induced hypercholesterolemia raises plasma LTIP mass 2.5-fold while suppressing its hepatic mRNA, diverging from CETP's response in hamsters and rabbits (J Lipid Res 2008)J Lipid Res · November 2008 6
• Plasma CETP activity tracks hepatic cholesterol synthesis machinery in humanized transgenic mice (Clin Exp Pharmacol Physiol 2006)Clin Exp Pharmacol Physiol · December 2006 6
• Type 2 diabetes eliminates the CETP elevation normally seen in obesity by suppressing hepatic CETP expression (J Clin Endocrinol Metab 2005)J Clin Endocrinol Metab · January 2005 6
• Insulin down-regulates CETP gene expression, reversing the elevation seen with insulin deficiency in transgenic mice (J Lipid Res 2003)J Lipid Res · July 2003 6
• Antisense knockdown of CETP in HepG2 cells raises cholesterol efflux to apoA-I but impairs SR-BI-mediated HDL cholesteryl ester uptake by the liver (Am J Physiol Endocrinol Metab 2003)Am J Physiol Endocrinol Metab · February 2003 6
• CETP deficiency slows parasite egg development, a possible reason it persists at high frequency across East Asia (Biochem Biophys Res Commun 2001)Biochem Biophys Res Commun · August 2001 6
• CETP transgenic mice reproduce the human-like cholesterol response to dietary fat type, with MUFA and PUFA lowering plasma cholesterol (Br J Nutr 2001)Br J Nutr · June 2001 6
• Feeding, not fasting, raises liver CETP mRNA two-fold and plasma CETP activity 20% in human-CETP transgenic mice, independent of insulin or glucose (J Nutr Biochem 2000)J Nutr Biochem · June 2000 6
• Blocking CETP production in liver cells boosts secretion of the smallest, most protective HDL form (Atherosclerosis 1999)Atherosclerosis · October 1999 6
• Ovariectomy reduces CETP activity in liver and adipose tissue of transgenic mice, and hormone replacement fails to restore it (Metabolism 1998)Metabolism · September 1998 6
• Simvastatin and cholestyramine both lower serum CETP activity in rabbits while leaving LCAT activity essentially unchanged (Cardiovasc Drugs Ther 1998)Cardiovasc Drugs Ther · March 1998 6
• Interferon alpha treatment for hepatitis C lowers CETP activity and mass alongside lipoprotein lipase and hepatic lipase (Hepatology 1997)Hepatology · June 1997 6
• CETP activity tracks its own mRNA closely in cholesterol-fed rabbits, while hepatic lipase regulation appears mostly post-transcriptional (Biochim Biophys Acta 1991)Biochim Biophys Acta · November 1991 6
• HepG2 hepatocytes secrete CETP activity bound mainly to apoA-I and apoA-II, unlike plasma's strong apoA-I skew, alongside a distinct heat-labile lipid-transfer inhibitor tied to apoE particles (Atherosclerosis 1989)Atherosclerosis · May 1989 6
• HepG2 human liver cells synthesize and secrete a protein immunochemically identical to plasma LTP-I, identifying hepatocytes as a candidate source (Arteriosclerosis 1987)Arteriosclerosis · January 1987 6
• The CETP TaqIB B1B2/B2B2 genotype raises the risk of fatty liver disease in Mexican women with gallstones (Metab Syndr Relat Disord 2023)Metab Syndr Relat Disord · October 2022 5
• In APOE3-Leiden.CETP mice with diet-induced NASH, the oxysterol Oxy210 reduces adipose tissue IL-6, MCP-1 and macrophage markers (Int J Mol Sci 2022)Int J Mol Sci · May 2022 5
• Ellagic acid from unripe Rubus coreanus extract lowers hepatic CETP and HMG-CoA activity while raising LCAT activity, reducing cholesterol in rats (Nutrients 2020)Nutrients · February 2020 5
• In hypertensive rats made to express human CETP, blood pressure rose and fatty liver accelerated, yet atherosclerosis did not (Hypertens Res 2020)Hypertens Res · January 2020 5
• High-dose dietary inulin shifts gut bacteria and raises short-chain fatty acids without reducing cholesterol or atherosclerosis in CETP-humanised mice (Sci Rep 2018)Sci Rep · November 2018 5
• Six-month high-fat feeding of CETP-humanised male mice reveals a biphasic lipid response with insulin resistance preceding dyslipidemia, mirroring human ageing (Physiol Rep 2017)Physiol Rep · October 2017 5
• Hepatic CETP secretion rises with dietary cholesterol in a dose-dependent, strain-independent manner in rabbits (Comp Biochem Physiol B Biochem Mol Biol 1996)Comp Biochem Physiol B Biochem Mol Biol · August 1996 5
• CETP transgenic mice develop more severe, faster-progressing fatty liver than controls, worse in males (Biochem Biophys Res Commun 1994)Biochem Biophys Res Commun · December 1994 5
• Sodium butyrate induces a 3- to 4-fold rise in CETP mRNA in HepG2 liver cells, a model for CETP hepatic regulation (Eur J Biochem 1993)Eur J Biochem · December 1993 5
• Doubling plasma CETP activity via diet does not speed cholesteryl ester clearance from hepatic reticuloendothelial cells in hamsters (Biochim Biophys Acta 1991)Biochim Biophys Acta · January 1991 5
• A four-protein urinary panel including CETP, combined with tumor diameter and AFP/GGT levels, predicts microvascular invasion in liver cancer with concordance indices up to 0.809 (BMC Med 2023)BMC Med · December 2023 4
• A CETP isoform, CETPI, is highlighted as a newly described contributor to LPS inactivation in the gut-liver axis of sepsis (Biomed Pharmacother 2021)Biomed Pharmacother · July 2021 4
• Feed efficiency correlates with distinct hepatic gene-expression patterns across diet duration in CETP-humanised mice, per a new dynamic model (Physiol Rep 2021)Physiol Rep · April 2021 4
• Review notes CETP transgene expression normalizes hepatic HDL cholesteryl ester delivery in humanized SR-BI knockout mice (World J Gastroenterol 2010)World J Gastroenterol · December 2010 4
• Thyromimetic T-0681 cuts atherosclerosis 80% in rabbits by raising hepatic LDL receptors, not by changing CETP (J Lipid Res 2008)J Lipid Res · December 2008 4
• Rabbit liver's nonparenchymal cells express more CETP mRNA than the parenchymal cells that dominate most other lipid genes (J Lipid Res 1993)J Lipid Res · November 1993 4