The class
Erabulenols A and B, new fungal metabolites from a soil Penicillium isolate, inhibit human CETP with IC50 values of 47.7 and 58.2 micromolar (J Antibiot (Tokyo) 1998)
Original title: Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. I.Production, isolation and biological properties
Penicillium sp. FO-5637, a soil isolate, was found to produce a series of cholesteryl ester transfer protein (CETP) inhibitors. Novel active compounds, erabulenols A and B, were isolated from the fermentation broth by solvent extraction, ODS column chromatography and HPLC. Erabulenols A and B inhibited human CETP activity with IC50 values of 47.7 and 58.2 microM, respectively, in an in vitro assay system containing 200 microM BSA.
Original abstract
Penicillium sp. FO-5637, a soil isolate, was found to produce a series of inhibitors of cholesteryl ester transfer protein (CETP). Novel active compounds, designated erabulenols A and B, were isolated from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography and HPLC. Erabulenols A and B inhibit human CETP activity with IC50 values of 47.7 and 58.2 microM in an in vitro assay system containing 200 microM BSA, respectively.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.