The class
Ferroverdin B, isolated from a soil Streptomyces, is among the most potent microbial CETP inhibitors known, with an IC50 of 0.62 micromolar (J Antibiot (Tokyo) 1999)
Original title: Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. I. Production, isolation and biological properties
From a soil isolate, Streptomyces sp. WK-5344, researchers isolated new CETP inhibitors ferroverdin B and ferroverdin C alongside the previously known ferroverdin A, purifying them from the fermentation broth by solvent extraction and column chromatography. All three ferroverdins showed dose-dependent inhibition of human CETP, with IC50 values of 21, 0.62, and 2.2 micromolar for ferroverdins A, B, and C respectively, making ferroverdin B one of the most potent CETP inhibitors of microbial origin identified.
Original abstract
Streptomyces sp. WK-5344, a soil isolate, was found to produce structurally related inhibitors of cholesteryl ester transfer protein (CETP). New active compounds, designated ferroverdins B and C, were isolated along with known ferroverdin A from the fermentation broth by solvent extraction, ODS column chromatography and silica gel column chromatography. All ferroverdins showed a dose-dependent inhibitory activity against human CETP. The IC50 values were 21, 0.62 and 2.2 microM for ferroverdins A, B and C, respectively, indicating that ferroverdin B is one of the most potent CETP inhibitors of microbial origin.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.