Genetics
CETP TaqI B1/B2 genotype differs significantly in men with venous thrombosis, tracking their low-HDL/high-LDL profile (Circulation 2005)
Original title: High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men
In 49 male venous thrombosis patients and matched controls under age 55, patients had significantly lower HDL particles, large HDL particles, HDL cholesterol, and apoA-I, and significantly higher LDL particles and small LDL particles, with odds ratios of 6.5 for decreased HDL particles and 6.0 for decreased apoA-I. Odds ratios for elevated apoB/apoA-I ratio and LDL/HDL cholesterol ratio were 6.3 and 2.7 respectively. Among polymorphisms tested in hepatic lipase, endothelial lipase, and CETP, only the CETP TaqI B1/B2 allelic frequency differed significantly between patients and controls, consistent with the observed low-HDL, high-LDL pattern, suggesting venous thrombosis-associated dyslipoproteinemia is linked to CETP genotype.
Original abstract
Background: Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients.
Methods And Results: We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged <55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 (95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 (95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL.
Conclusions: Venous thrombosis in men aged <55 years old is associated with dyslipoproteinemia involving lower levels of HDL particles, elevated levels of small LDL particles, and an elevated ratio of apolipoprotein B/apolipoprotein AI. This dyslipoproteinemia seems associated with a related cholesteryl ester transfer protein genotype difference.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.