Genetics
CETP I405V VV genotype cuts myocardial infarction risk in men by 43 percent in the Rotterdam Study (Eur J Cardiovasc Prev Rehabil 2007)
Original title: The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
This study examined the effect of the CETP I405V polymorphism on lipid levels, atherosclerosis, and myocardial infarction (MI) risk in 6421 participants of the Rotterdam Study, using linear models for quantitative outcomes and Cox models for MI risk. HDL-cholesterol increased by 0.06 mmol/L (95% CI 0.03-0.09) in VV genotype carriers. The V allele was further associated with decreased MI risk in men (hazard ratio 0.57, 95% CI 0.45-0.73, VV versus II, Ptrend=0.02). The authors conclude this study provides additional evidence for the CETP-HDL association and suggests CETP is an atherogenic protein that increases MI risk.
Original abstract
Background And Design: The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study.
Methods: Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk.
Results: High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02).
Conclusion: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.