Genetics
CETP B1B1 genotype is nearly twice as common in Taiwanese people with a parental history of cardiovascular disease (Med Princ Pract 2008)
Original title: Cholesteryl ester transfer protein B1B1 genotype is associated with a parental history of cardiovascular diseases in Taiwanese people
This cross-sectional study investigated the association between family history of cardiovascular disease (CVD) and the CETP TaqIB polymorphism in 240 Taiwanese subjects (115 men, 125 women), divided by presence or absence of parental CVD history, genotyped by PCR-RFLP. The B1B1 genotype frequency was significantly higher in subjects with a parental CVD history than without (31.2% vs 18.8%, OR 1.97, 95% CI 1.084-3.579, p=0.035). Siblings with the B1B1 genotype had significantly lower HDL-cholesterol than siblings with B1B2 (46.7 vs 52.5 mg/dL, p=0.034) or B2B2 genotypes (46.7 vs 55.2 mg/dL, p=0.01). The authors conclude the CETP TaqIB polymorphism is associated with plasma HDL-cholesterol levels, and the B1B1 genotype may influence CVD susceptibility in Taiwan.
Original abstract
Objective: To investigate the association between family history of cardiovascular disease (CVD) and cholesteryl ester transfer protein (CETP) TaqIB polymorphism in Taiwanese subjects.
Subjects And Methods: In this cross-sectional study, 240 subjects (115 men and 125 women) were divided into two groups based on whether or not they had a parental history of CVD. Polymerase chain reaction/restriction fragment length polymorphism was used to analyze the genotype of the subjects for the TaqIB polymorphism of CETP in intron 1.
Results: The frequency of the B1B1 genotype was significantly higher in Taiwanese subjects with a family history of CVD than in those without it (31.2 vs. 18.8%, odds ratio = 1.97, 95% confidence interval = 1.084-3.579, p = 0.035). Siblings with the B1B1 genotype had lower levels of serum high-density lipoprotein cholesterol (HDL-C) than siblings with either B1B2 (46.7 +/- 11.0 vs. 52.5 +/- 11.1 mg/dl, p = 0.034) or B2B2 genotypes (46.7 +/- 11.0 vs. 55.2 +/- 9.6 mg/dl, p = 0.01).
Conclusion: CETP TaqIB polymorphism is associated with plasma HDL-C levels. The CETP B1B1 genotype may influence the susceptibility to CVD in Taiwan.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.