Genetics
CETP I405V V-allele carriers lose more ApoA-I and HDL cholesterol when switched from a high to low polyunsaturated fat diet (Horm Metab Res 2009)
Original title: Cholesteryl ester transfer protein I405V polymorphism influences apolipoprotein A-I response to a change in dietary fatty acid composition
This study investigated whether the CETP I405V polymorphism modifies the response to changes in dietary polyunsaturated-to-saturated fat ratio (P:S), in 85 healthy subjects with different I405V genotypes (35 II, 36 IV, 14 VV) who consumed a high-P:S diet (ratio 1.2) for 28 days followed by a low-P:S diet (ratio 0.3) for another 28 days, with serum lipid, lipoprotein, and CETP concentrations measured at each transition. Lipid and lipoprotein concentrations did not differ significantly among genotype groups at screening. After the low-P:S diet, V allele carriers had a greater reduction in apoA-I and HDL-cholesterol than II genotype carriers, with a significant genotype-by-diet interaction for apoA-I (p=0.016). The authors conclude the CETP I405V polymorphism contributes to unfavorable changes in apoA-I and HDL-cholesterol when a high-P:S diet is replaced with a low-P:S diet.
Original abstract
The aim of the present study was to investigate whether the cholesteryl ester transfer protein (CETP) I405V polymorphism modifies the response to changes in the dietary ratio of polyunsaturated to saturated fat (P:S). The population included 85 healthy subjects with the different I405V genotypes (35 II, 36 IV, and 14 VV) assigned to two consecutive 28-day experimental period. All subjects consumed a high-P:S with P:S of 1.2 for the first period and a low-P:S with a P:S of 0.3 for the next 28-day period. At the first and end of each dietary period, serum lipid, lipoprotein, and CETP concentrations were measured. At screening, lipid or lipoprotein concentrations were not significantly different among CETP I405V genotype groups. After the low-P:S diet, subjects carrying V allele had greater reduction in apoA-I and HDL cholesterol (HDL-C) than subjects with II genotype. A genotype-by-diet interaction effect was observed on apoA-I (p=0.016) concentrations. In conclusion, the CETP I405V polymorphism contributes to the unfavorable changes of apoA-I and HDL-C when a high-P:S diet was replaced with a low-P:S diet.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.