Genetics
CETP TaqIB polymorphism does not predict coronary restenosis after angioplasty and stenting (Angiology 2010)
Original title: Lack of association between the cholesteryl ester transfer protein gene--TaqIB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty and stenting: a pilot study
This pilot study investigated the frequency of the CETP TaqIB polymorphism and its possible association with coronary restenosis following percutaneous transluminal coronary angioplasty (PTCA) and stenting, in 204 Greek patients who had undergone the procedure, also exploring interacting effects with cardiovascular risk factors and an alpha(2B)-adrenergic receptor gene deletion. The TaqIB polymorphism frequency was 54%, similar to that in a group of 35 healthy controls. The authors conclude the TaqIB variation at the CETP gene locus is not a significant predictor of coronary restenosis risk after PTCA and stenting, and this result was unaffected by any of the additional factors studied.
Original abstract
Background: The most widely studied variation at the cholesteryl ester transfer protein (CETP) gene locus is a silent base change called the Thermobius aquaticus IB (TaqIB) polymorphism. TaqIB has been shown to affect levels/activity of CETP, plasma levels of high-density lipoprotein cholesterol (HDL-C), and to contribute to the risk of developing atherosclerosis and coronary heart disease (CHD). Ongoing studies are investigating possible associations between CETP gene polymorphisms and the development of coronary restenosis following percutaneous transluminal coronary angioplasty (PTCA) and stenting.
Methods And Results: The primary objective of the present study was to investigate the frequency of TaqIB-polymorphism, and a possible association with post-PTCA coronary restenosis, in 204 Greek patients who had undergone PTCA and stenting. As a secondary objective, the analysis was extended to explore possible interacting or additive effects by various CHD risk factors, and a deletion in the alpha(2B)-adrenergic receptor gene. The frequency of TaqIB was 54%, similar to the frequency of the polymorphism in a group of 35 healthy controls.
Conclusions: The results from this study do not indicate that the TaqIB variation at the CETP gene locus is a significant predictor for assessing the risk of developing coronary restenosis following PTCA and stenting. This result was not affected when considering any one of the additionally studied factors.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.