Genetics
CETP Taq1B polymorphism shows no effect on HDL cholesterol or coronary artery disease risk in a Turkish angiography cohort (Genet Test Mol Biomarkers 2010)
Original title: Cholesteryl ester transfer protein Taq1B polymorphism in an angiographically assessed Turkish population: no effects on coronary artery disease risk
This study investigated the effects of the CETP Taq1B polymorphism on HDL-cholesterol (HDL-C) and coronary artery disease (CAD) risk in one hundred thirty-five angiographically defined CAD patients and 112 healthy controls, screened for genotype and plasma lipids. Genotype frequencies were similar between CAD patients and controls. HDL-cholesterol levels were significantly lower across all genotypes in the CAD group compared to corresponding controls, but this difference was not attributable to Taq1B genotype: smoking and plasma triglycerides predicted HDL-cholesterol in B1B1 carriers, while smoking and sex predicted it in carriers of the polymorphic B2 allele. The authors conclude the CETP Taq1B polymorphism neither determines HDL-cholesterol levels nor serves as a useful predictor of CAD risk in this population.
Original abstract
Background: Taq1B polymorphism of cholesteryl ester transfer protein (CETP) is believed to associate with high-density lipoprotein-cholesterol (HDL-C) levels and may alter the susceptibility to atherosclerosis.
Aim Of The Study: This study investigated the effects of Taq1B polymorphism on HDL-C and coronary artery disease (CAD) risk in angiographically defined CAD patients.
Methods: One hundred thirty-five CAD patients and 112 healthy controls were screened for the CETP Taq1B genotype and plasma lipids.
Results: The genotype frequency of CAD patients and controls were similar. The HDL-C levels of all genotypes in the CAD group were significantly lower than the corresponding controls. Smoking and plasma triglycerides were the predictors of the HDL-C level in B1B1 bearers, whereas the subjects with a polymorphic B2 allele were affected by smoking and sex.
Conclusion: CETP Taq1B polymorphism neither plays a role in determining HDL-C levels nor is a useful predictor of the risk of CAD.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.