Genetics
CETP Taq1B B2B2 genotype is linked to the highest HDL cholesterol and lowest oxidative stress marker levels in Tehran adults (Lipids Health Dis 2010)
Original title: Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study
This cross-sectional study examined the association between the CETP Taq1B polymorphism and the LIPC -514C/T polymorphism with serum lipid levels and lipid peroxidation in a subgroup of the Tehran Lipid and Glucose Study population, where low HDL-cholesterol (HDL-C) is highly prevalent. Serum HDL-C was significantly associated with CETP Taq1B genotype, with B2B2 subjects having the highest levels compared to B2B1 and B1B1 (37.9 vs 36.9 vs 35.3 mg/dL, P=0.01). Carriers of the B1 allele had significantly lower total cholesterol (200.1 vs 215.2 mg/dL, P=0.005), HDL-C (35.8 vs 37.9 mg/dL, P=0.009), and malondialdehyde, a lipid peroxidation marker (4.5 vs 5.0 nmol/mL, P=0.031), than B2B2 non-carriers. LIPC T allele carriers had higher HDL-C than non-carriers (37.7 vs 35.7 mg/dL, P=0.04), with no other significant LIPC associations found. The authors conclude both polymorphisms are associated with serum HDL-C levels.
Original abstract
Background: Low level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.
Objectives: To determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.
Results: Serum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.
Conclusion: This study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.