The class
Natural compound isolated from ginger rhizome inhibits CETP with an IC50 of 35 micromolar (Arch Pharm Res 2011)
Original title: The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale
Searching for CETP inhibitors from natural sources, researchers isolated a compound, [10]-dehydrogingerdione, from the rhizomes of ginger (Zingiber officinale). NMR spectroscopic analysis, including COSY, HMBC, HMQC, and NOESY, refined the compound's structure relative to earlier proposals. The isolated compound inhibited human plasma CETP with an IC50 of 35 micromolar, adding a natural-product scaffold to the catalog of small molecules capable of directly inhibiting CETP activity.
Original abstract
In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 μM.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.