The class
Review synthesises structural and biophysical evidence for how CETP moves lipids between HDL and LDL (Biochem Soc Trans 2011)
Original title: Structural and biophysical insight into cholesteryl ester-transfer protein
This review examines the structural and biophysical basis of CETP-mediated neutral lipid transfer between HDL and LDL, a process central to the reverse cholesterol transport pathway. Since CETP inhibitors have been shown in clinical trials to raise HDL and lower LDL levels, potentially offering a treatment for atherosclerosis, the authors bring together available structural and biophysical data on CETP to provide mechanistic insight into how the protein mediates lipid transfer. The review aims to inform understanding of CETP structure as a basis for interpreting and improving CETP-targeted therapeutic strategies.
Original abstract
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.