HDL biology
Women with angina pectoris show enhanced CETP activity in both HDL and LDL alongside impaired HDL antioxidant enzymes (Int J Mol Med 2011)
Original title: Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes
Comparing lipoprotein composition in 22 women with angina pectoris and 20 age- and gender-matched controls, researchers found the angina group had increased LDL triglyceride and protein content, lower HDL total cholesterol, and elevated HDL triglyceride. CETP activity was enhanced in both HDL and LDL fractions in the angina group, while LCAT activity in HDL3 was almost depleted. Antioxidant activity was significantly reduced in HDL3, with smaller HDL2 particle size; paraoxonase and PAF-acetylhydrolase activity were much lower in HDL3, while CETP and apoC-III levels were elevated there. LDL from angina patients was also more susceptible to copper-mediated oxidation, together indicating impaired antioxidant function alongside structurally and functionally altered, CETP-enriched lipoproteins in women with angina.
Original abstract
In order to investigate non-invasive biomarkers for angina pectoris (AP), we analyzed the lipid and protein composition in individual lipoproteins from females with angina pectoris (n=22) and age- and gender-matched controls (n=20). In the low-density lipoprotein (LDL) fraction, the triglycerides (TG) and protein content increased in the AP group compared to the control group. The AP group had lower total cholesterol (TC) and elevated TG in the high-density lipoprotein (HDL) fraction. In the AP group, cholesteryl ester transfer protein (CETP) activity was enhanced in HDL and LDL, while lecithin:cholesterol acyltransferase (LCAT) activity in HDL3 was almost depleted. Antioxidant activity was significantly decreased in the HDL3 fraction, with a decrease in the HDL2 particle size. In the HDL3 fraction, paraoxonase and platelet activating factor-acetylhydrolase (PAF-AH) activity were much lower and the levels of CETP and apoC-III were elevated in the AP group. The LDL from the AP group was more sensitive to cupric ion-mediated oxidation with faster mobility. In conclusion, the lipoprotein fractions in the AP group had impaired antioxidant activity and increased TG and apoC-III with structural and functional changes.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.