The class
Quinoline-3-carboxamide derivatives reach 80.1 percent CETP inhibitory activity in newly designed series (Molecules 2012)
Original title: Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors
Researchers designed and synthesised a series of novel quinoline-3-carboxamide derivatives, compounds 10 through 17 and 23 through 27, as candidate cholesteryl ester transfer protein (CETP) inhibitors. All the compounds tested showed activity against CETP, with compounds 24 and 26 the most potent, both reaching the same inhibitory rate of 80.1 percent. The work identifies quinoline-3-carboxamides as a new chemical scaffold for CETP inhibitor development.
Original abstract
A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.