The class
Endogenous CETP activity above 34% marks high cardiovascular risk in a cohort of 1,403 patients (Atherosclerosis 2013)
Original title: Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range
Researchers measured endogenous plasma CETP activity in 1403 individuals to identify its key determinants and a threshold value associated with high cardiovascular risk. Multivariate analysis found that 23.5% of the variability in CETP activity was explained by plasma LDL-C (12.0%), HDL-C (6.4%), and triglycerides (4.4%), while sex and BMI together accounted for only 0.7%. Scoring patients for cardiovascular risk based on total cholesterol, triglycerides, LDL-C, and HDL-C, the authors found that patients with high cardiovascular risk (score of 3 or more) had a mean endogenous plasma CETP activity above 34%. The authors conclude plasma CETP activity is a useful indicator of cardiovascular risk in patients with metabolic disorders because it integrates several major independent risk factors.
Original abstract
Objectives: To identify key determinants of plasma endogenous CETP activity and threshold value of plasma CETP activity associated with high cardiovascular risk.
Methods: Endogenous plasma CETP activity was measured in a total of 1403 individuals.
Results: Multivariate analysis revealed that 23.5% of endogenous CETP activity variability was explained by plasma LDL-C (12.0%), HDL-C (6.4%) and TG (4.4%) whereas sex and BMI accounted together for only 0.7% of its variability. Scoring patients for cardiovascular risk on the basis of their plasma lipid levels (TC, TG, LDL-C and HDL-C), revealed that patients with high cardiovascular risk (score ≥3) displayed a mean endogenous plasma CETP activity above 34%.
Conclusion: Plasma CETP activity represents a potent indicator of cardiovascular risk in patients with metabolic disorders since it integrates major independent risk factors.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.