Mechanisms
LCAT and CETP activity track with disturbed HDL and triglyceride-rich lipoprotein composition after kidney transplant (Cell Biochem Biophys 2013)
Original title: Association between lipids, lipoproteins composition of HDL particles and triglyceride-rich lipoproteins, and LCAT and CETP activity in post-renal transplant patients
Researchers examined lipid, apolipoprotein, and enzyme profiles in 57 post-renal-transplant patients, with and without statin therapy, compared with 15 healthy controls, focusing on lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) activity. Transplant patients showed moderate hypertriglyceridemia, hypercholesterolemia, disturbed triglyceride-rich lipoprotein and HDL composition, and decreased LCAT activity. Correlation analysis linked lipid and lipoprotein levels to LCAT and CETP activity, and regression analysis showed that immunosuppressive therapy disturbed HDL and triglyceride-rich lipoprotein composition. The authors conclude that altered apolipoprotein composition of HDL and triglyceride-rich lipoproteins, mediated in part through LCAT and CETP, can worsen the lipid profile, aggravate renal graft outcomes, and accelerate atherosclerosis in transplant patients.
Original abstract
High-density lipoprotein (HDL) remodeling within the plasma compartment and the association between lecithin-cholesterol acyltransferase (LCAT) and cholesterol ester transfer protein (CETP) activity, and lipid, lipoprotein concentrations and composition were investigated. The aim was to examine the high sensitivity of C-reactive protein (hsCRP), lipid, apolipoprotein B (apoB), apoAI, total apoAII, apoAIInonB, apoB-containing apoAII (apoB:AII), total apoCIII, apoCIIInonB, apoB-containing apoCIII (apoB:CIII) concentration and LCAT and CETP activity to gain an insight into the association between them and LCAT and CETP, 57 post-renal transplant (Tx) patients with and without statin therapy and in 15 healthy subjects. Tx patients had moderate hypertriglyceridemia, hypercholesterolemia, and dyslipoproteinemia, disturbed triglyceride-rich lipoproteins (TRLs) and HDL composition, decreased LCAT, and slightly increased hsCRP but no CETP activity. Spearman's correlation test showed the association between lipids and lipoproteins and LCAT or CETP, and multiple ridge stepwise forward regression showed that immunosuppressive therapy in Tx patients can disturb HDL and TRLs composition. The results suggest that inhibition or activation of LCAT is due, in part, to HDL-associated lipoprotein. Lipoprotein composition of apoAI, apoAIInonB, and apoCIIInonB in HDL particle and apoB:AII TRLs can contribute to decrease LCAT mass in Tx patients. Tx patients without statin and with lower triglycerides but higher HDL cholesterol concentration and disturbed lipoprotein composition of ApoAI and apoAII in HDL particle can decrease LCAT, increase LDL cholesterol, aggravate renal graft, and accelerate atherosclerosis and chronic heart diseases.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.