Genetics
Meta-analysis of seven CETP variants finds rs708272 and rs1800775 are promising biomarkers for myocardial infarction risk (PLoS One 2014)
Original title: Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression
This meta-analysis and meta-regression evaluated the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk, searching eight databases for studies published before March 1, 2013. Nine case-control studies with 8,623 MI cases and 8,564 healthy controls met inclusion criteria. CETP rs708272 (C>T) was correlated with increased MI risk, especially among Caucasians, and CETP rs1800775 (C>A) was also found to increase MI risk. No similar associations were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), or rs4783961 (G>A). The authors conclude that CETP rs708272 and rs1800775 polymorphisms may contribute to MI susceptibility, especially in Caucasians, and could serve as promising biomarkers for early MI diagnosis.
Original abstract
Objective: This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk.
Method: The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.
Results: Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms.
Conclusion: The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.