Genetics
CETP I405V Val/Val genotype significantly determines HDL cholesterol levels in myocardial infarction patients (J Clin Diagn Res 2014)
Original title: Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study
This case-control study examined the relationship between the CETP I405V genotype and lipid fractions, including HDL-cholesterol and the total cholesterol to HDL-cholesterol ratio, in 100 acute myocardial infarction patients and 100 matched healthy controls, with serum lipids measured by standard methods and genotyping by ARMS PCR. The CETP 405Val genotype was present in both patients and controls. HDL-cholesterol (p less than 0.0001) and the total cholesterol to HDL-cholesterol ratio (p less than 0.0043) were significantly associated with the Val/Val genotype. The Val/Val genotype was also associated with inhibition of CETP activity, corresponding to higher HDL-cholesterol and a lower total cholesterol to HDL-cholesterol ratio. The authors conclude the CETP I405V genotype is a significant determinant of HDL-cholesterol in patients with coronary heart disease.
Original abstract
Objectives: We determine the significant relation of HDL cholesterol and total cholesterol/HDL cholesterol between CETP I405V genotypes and activity of CETP. CETP is an essential for transfer of cholesterol ester to the liver from peripheral tissues which facilitating its transfer to TG rich VLDL. Reduction activity of CETP I405V may associate with genotypes of CETP I405V. This study is undertaken to assess the presence and impact of CETP I405V genotype in our population.
Materials And Methods: In this study 100 acute myocardial infarction patients and 100 normal age & sex matched healthy individuals were included. Serum Lipid profile was estimated by using universal standard methods whereas CETP I405V genotype was studied by ARMS PCR.
Result: There is presence of CETP 405Val genotype both in patient as well as in control group. RESULTs show that HDL cholesterol (p<0.0001) and ratio of total cholesterol/HDL cholesterol are significantly (p<0.0043) associated with Val/Val genotype. In addition to that the CETP I405V genotype is associated with inhibition of CETP activity with higher HDL-C level and decreased total cholesterol/HDL cholesterol ratio.
Conclusion: Our results show that the CETP I405V genotypes are very much significantly determinant of HDL cholesterol in patients with CHD.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.