CETP TaqIB B2B2 genotype is linked to more favorable HDL cholesterol levels in West Siberian Caucasians (Bull Exp Biol Med 2014)

TaqIB polymorphism of the gene encoding cholesterol ester transporting protein (CETP) was analyzed in the Caucasian population of West Siberia and in groups contrast by total serum cholesterol content. The patients were selected for the study from the main sample of HAPIEE project (9600 examined subjects aged 45-69 years, 50% men). Analysis was carried out in 293 patients with high levels of total cholesterol (>300 mg/dl), 293 patients with normal and low levels of total cholesterol (<200 mg/dl), and 265 patients represented the population sample (mean level of total cholesterol 235.8±43.9 mg/dl). The frequencies of B1B1, B1B2, and B2B2 genotypes in the population were 27.5, 54.8, and 17.7%, respectively. The incidence of allele B2 was 45.1, 45.2, and 50.2% in the population and in groups with normal and high total cholesterol levels, respectively (p>0.05). Associations of CETP gene TaqIB (rs708272) polymorphism with HDL cholesterol levels was detected in groups with high and low total cholesterol levels (p=0.014 and p=0.008). CETP gene TaqIB polymorphism B2B2 genotype was associated with high level of HDL cholesterol and a more favorable lipid profile.