Genetics
Meta-analysis links the CETP rs5882 A allele to increased Alzheimer's disease risk in Caucasians (DNA Cell Biol 2014)
Original title: Relationships between CETP genetic polymorphisms and Alzheimer's disease risk: a meta-analysis
This meta-analysis of nine case-control studies, totalling 2172 Alzheimer's disease patients and 8017 healthy controls, evaluated two common CETP polymorphisms, rs708272 T greater than C and rs5882 A greater than G, for association with Alzheimer's disease risk. The rs5882 A allele was associated with increased Alzheimer's disease risk overall (A versus G, odds ratio 1.11; AA plus AG versus GG, odds ratio 1.28; AA versus GG, odds ratio 1.32), an association driven by Caucasian subgroups (odds ratio 1.10 to 1.35) and not seen among Asians. No association was found between rs708272 and Alzheimer's disease risk in either ethnicity. The authors conclude CETP rs5882 A greater than G may contribute to Alzheimer's disease susceptibility, particularly in Caucasians, while rs708272 does not appear to be an important determinant.
Original abstract
This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms in the CETP gene and the risk of Alzheimer's disease (AD). The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched from inception through October 1, 2013, without language restrictions. Nine case-control studies with a total of 2172 AD patients and 8017 healthy controls were involved in this meta-analysis. Two common polymorphisms (rs708272 T>C and rs5882 A>G) in the CETP gene were assessed. Our meta-analysis results showed that CETP rs5882 A>G polymorphism might increase the risk of AD (A allele vs. G allele: odds ratio [OR]=1.11, 95% confidence interval [95% CI]=1.02-1.21, p=0.014; AA+AG vs. GG: OR=1.28, 95% CI=1.07-1.52, p=0.006; AA vs. GG: OR=1.32, 95% CI=1.10-1.70, p=0.003; AA vs. AG: OR=1.25, 95% CI=1.03-1.50, p=0.020; respectively). However, we found no correlations of CETP rs708272 T>C polymorphism with AD risk (all p>0.05). Subgroup analysis by ethnicity suggested positive associations between CETP rs5882 A>G polymorphism and an increased risk of AD among Caucasians (A allele vs. G allele: OR=1.10, 95% CI=1.01-1.21, p=0.014; AA+AG vs. GG: OR=1.34, 95% CI=1.06-1.69, p=0.015; AA vs. GG: OR=1.35, 95% CI=1.07-1.70, p=0.011; respectively), but not among Asians (all p>0.05). No associations were found between CETP rs708272 T>C polymorphism and AD risk among both Asians and Caucasians (all p>0.05). Our findings provide empirical evidence that CETP rs5882 A>G polymorphism may contribute to susceptibility to AD, especially among Caucasians. However, CETP rs708272 T>C polymorphism does not seem to be an important determinant in the pathogenesis of AD.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.