Genetics
CETP variant rs5882 determines whether plant sterol consumption lowers triglycerides, crossover trial finds (Appl Physiol Nutr Metab 2015)
Original title: Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption
This dual-centre, single-blind, randomized crossover trial tested whether the CETP SNP rs5882 modifies the triglyceride-lowering response to plant sterol (PS) consumption (2 g/day for 4 weeks), given inconsistent prior clinical trial evidence on whether PS lowers triglycerides in humans. Triglyceride concentrations were significantly lowered in homozygotes for the minor G allele of rs5882 (-0.46 plus or minus 0.13 mmol/L, p=0.002, n=10), while there was no effect in A allele carriers. The authors conclude the CETP rs5882 genotype determines the triglyceride-lowering response to plant sterol consumption.
Original abstract
Recent work suggests that plant sterol (PS) consumption may lower triglyceride (TG) concentrations; however, human clinical trial evidence is inconsistent. We associated SNP r5882 in cholesteryl ester transfer protein with changes in TG concentrations following PS consumption (2 g/day for 4 weeks) in a dual-centre, single-blind, randomized, crossover trial. TG concentrations were lowered in homozygotes for the minor G-allele of rs5882 (-0.46 ± 0.13 mmol/L, p = 0.002, n = 10); there was no effect in the A-allele carriers.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.