Genetics
Meta-analysis confirms the CETP TaqIB B2 allele protects against ischemic stroke (J Stroke Cerebrovasc Dis 2017)
Original title: Effect of Cholesteryl Ester Transfer Protein Gene TaqIB Polymorphism on the Risk of Ischemic Stroke: A Meta-Analysis
This meta-analysis investigated whether the CETP TaqIB polymorphism is associated with ischemic stroke (IS) risk, given previously conflicting results, searching PubMed, Web of Science, and three Chinese databases through January 16, 2017. Six case-control studies with 1494 cases and 1370 controls were identified. An association between CETP TaqIB polymorphism and IS was found across all four genetic models tested: B2B2 versus B1B1 (OR=.63, 95% CI .51-.79, P less than .001), B1B2+B2B2 versus B1B1 (OR=.75, 95% CI .64-.87, P less than .001), B2B2 versus B1B2+B1B1 (OR=.70, 95% CI .57-.85, P less than .001), and B2 versus B1 (OR=.78, 95% CI .70-.87, P less than .001). Similar protective effects were observed in the Asian population subgroup. The authors conclude the CETP TaqIB B2 allele is a protective factor against ischemic stroke.
Original abstract
Background: The association between cholesteryl ester transfer protein (CETP) TaqIB polymorphism and ischemic stroke (IS) risk has generated conflicting results. To investigate whether the TaqIB polymorphism of the CETP gene was associated with the risk of IS, a meta-analysis was performed.
Methods: Studies were retrieved by searching PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Wanfang Database, and the Chinese VIP Database before January 16, 2017. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the association. Depending on the heterogeneity the fixed-effects model or the random-effects model was used.
Results: A total of 6 case-control studies were identified with 1494 cases and 1370 controls. Overall, an association of CETP TaqIB polymorphism with IS was found in the 4 genetic models (B2B2 versus B1B1: OR = .63, 95% CI = .51-.79, P < .001; B1B2 + B2B2 versus B1B1: OR = .75, 95% CI = .64-.87, P < .001; B2B2 versus B1B2 + B1B1: OR = .70, 95% CI = .57-.85, P < .001; B2 versus B1: OR = .78, 95% CI = .70-.87, P < .001). In the subgroup analysis by ethnicity, similar risks were also observed in Asian population.
Conclusions: This meta-analysis indicates that CETP TaqIB polymorphism is associated with IS risk, and the B2 allele is a protective factor for IS.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.