Genetics
Dietary fat intake modifies how CETP variant rs5882 affects HDL cholesterol and blood pressure risk (Iran J Basic Med Sci 2018)
Original title: Cholesteryl ester transfer protein gene variations and macronutrient intakes interaction in relation to metabolic syndrome: Tehran lipid and glucose study
This nested case-control study from the Tehran Lipid and Glucose Study examined the interaction between CETP polymorphisms rs5882 and rs3764261 and macronutrient intake in relation to metabolic syndrome (MetS) or its components, comparing 441 MetS cases individually matched with 844 non-MetS controls. No significant gene-diet interactions were found between rs5882 and macronutrient intake for overall MetS risk. However, the risk of low HDL-cholesterol was lower in the lowest quartile of monounsaturated fat and total fat intake among G allele carriers of rs5882 compared to the AA genotype group, while the risk of high blood pressure increased significantly at higher trans-fatty acid intake (above 1.81% of total energy) in G allele carriers compared to AA genotype carriers. No significant interactions were found between rs3764261 and macronutrient intakes for MetS or its components.
Original abstract
Objectives: There are controversial results regarding the effect of the interaction of CETP polymorphisms with dietary fats on the lipid profiles. The aim of this study was to examine the effect of CETP polymorphisms (rs5882 and rs3764261) and macronutrient intakes interaction in relation to metabolic syndrome (MetS) or its components.
Materials And Methods: In this nested case-control study, subjects were selected from among participants of the Tehran Lipid and Glucose Study. Cases (n=441) were individually matched with two controls (844 non-MetS subjects). DNA samples were genotyped with HumanOmniExpress-24-v1-0 bead chips, including 649,932 SNP loci.
Results: The mean ages at baseline were 38.1±10 and 37.0±10 years in women and 36.2±11 and 36.3±11 years in men, respectively in cases and controls. We did not find significant gene-diet interactions between rs5882 and dietary macronutrient intakes in relation to MetS risk. The risk of low HDL-C was lower in the first quartile of MUFA and total fat intake in G allele carriers, compared to AA genotype group. The risk of high BP appeared to increase significantly in higher quartiles of trans-fatty acid intakes (>1.81% of total energy intake) in G allele carriers compared with the AA genotype group. No significant interactions were found between rs3764261 and macronutrient intakes in association with MetS or its components.
Conclusion: Our findings demonstrate that dietary fats modify the association of rs5882 and risk of low HDL-C and high blood pressure.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.