Genetics
Two CETP polymorphisms and a three-locus haplotype raise coronary artery disease risk in a Polish population (Mol Biol Rep 2018)
Original title: Relationship between CETP gene polymorphisms with coronary artery disease in Polish population
This study examined whether CETP polymorphisms rs1532624, rs247616, and rs708272 are associated with coronary artery disease (CAD) in a Polish population, measuring serum lipid levels and genotyping 248 patients with premature CAD and 246 blood donor controls. CAD risk was significantly higher for CC homozygotes and C allele carriers of rs247616 than for T allele carriers (OR 1.89, 95% CI 1.29-2.76, p=0.001 and OR 1.51, 95% CI 1.14-1.99, p=0.003), and likewise for the CC genotype of rs1532624 versus the A allele (OR 1.59, 95% CI 1.05-2.40, p=0.026). T allele carriers of rs708272 had significantly higher total cholesterol than CC homozygotes in healthy controls (p less than 0.05). A three-locus allelic pattern across rs247616, rs708272, and rs1532624 increased CAD susceptibility by 43% (OR 1.43, 95% CI 1.10-1.85, p=0.006). The authors conclude rs247616 and rs1532624 may modulate CAD risk in this population.
Original abstract
The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays a crucial role in the reverse transport of cholesterol. The aim of the present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) in a Polish population. Serum lipid levels and single nucleotide polymorphisms of CETP genes were determined in 494 subjects: 248 patients with premature CAD and 246 blood donors as controls. Selected polymorphisms were examined using TaqMan PCR analysis. We found that CAD risk was significantly higher for CC homozygotes and C allele carriers of the rs247616 polymorphism than for carriers with the T allele (OR 1.89, 95% CI 1.29-2.76, p = 0.001 and OR 1.51, 95% CI 1.14-1.99, p = 0.003) and likewise for the CC genotype of the rs1532624 polymorphism than for those with the A allele (OR 1.59, 95% CI 1.05-2.40, p = 0.026). Moreover, T allele carriers of the rs708272 polymorphism had significantly higher total cholesterol levels compared to CC homozygotes (p < 0.05) in the healthy controls. We also observed an allelic pattern, C(rs2477616)C(rs708272)C(rs1532624), which increased susceptibility to CAD by 43% (OR = 1.43, 95% CI 1.10-1.85, p = 0.006). In conclusion, the rs247616 and rs1532624 polymorphisms of CETP may modulate the risk of CAD in Polish population.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.