Genetics
CETP rs5883 polymorphism does not distinguish coronary artery disease patients from controls in a Turkish cohort (In Vivo 2019)
Original title: Characteristics of Coronary Artery Disease Patients Who Have a Polymorphism in the Cholesterol Ester Transfer Protein (CETP) Gene
Researchers examined the CETP rs5883 gene polymorphism in 45 Turkish coronary artery disease patients and 45 matched controls, alongside HDL and LDL cholesterol levels. Genotype frequencies of the rs5883 polymorphism did not differ significantly between patients and controls, and no association was found between the polymorphism and HDL or LDL levels. Patients did have higher BMI, and higher rates of treatment, hypertension, and type 2 diabetes than controls, and small HDL particle levels were higher in the control group. The study provides a clean null result for this specific CETP variant as a marker of coronary artery disease risk in a Turkish population.
Original abstract
Background/Aim: Cholesterol ester transfer protein (CETP) is responsible for the transformation of high density lipoprotein (HDL) to low density lipoprotein (LDL) and is a risk factor for atherosclerosis. Our study investigated the association of the rs5883 CETP gene polymorphism with HDL and LDL levels, in 45 coronary artery disease patients and 45 control patients.
Materials And Methods: CETP gene polymorphism was detected using Real Time-Polymerase Chain Reaction (RT-PCR). Lipoprotein levels were measured using Quantimetrix system.
Results: There were lack of associaition regarding CETP polymorphism in atherosclerosis and HDL and LDL levels (p>0.05) BMI was higher among coronary artery disease patients (CADP) compared to the control group (28.97±6.38, 26.52±4.39 respectively, p<0.03). Frequency of CADP (82.6 %, n=19) who were taking treatment was higher (17.4 %, n=4) (p<0.00). The frequencies of hypertension and type-2 diabetes were higher among CADP (p<0.00). Families of CADP have more CADP (p<0.02). Small HDL particle levels were higher in the control group (p<0.00).
Conclusion: In Turkey, BMI, and frequencies of hypertension and type-2 diabetes were higher among CADP than among healthy controls. Furthermore, the genotypes of the rs5883 CETP gene polymorphism did not differ between CADP and healthy controls.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.