CETP variant rs708272 is linked to reduced risk of pituitary adenoma and its recurrence (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020)

Original title: Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub · 17 April 2019 · 5

Sidaraite A, Liutkeviciene R, Glebauskiene B, Vilkeviciute A, Kriauciuniene L

This study evaluated the association of CETP single nucleotide polymorphisms rs5882 and rs708272 with the presence, invasiveness, hormonal activity, and recurrence of pituitary adenoma (PA), genotyping 142 patients with PA and 753 healthy controls. The CETP rs708272 genotype G/A, under an over-dominant model, was associated with decreased odds of PA overall (OR=0.637, 95% CI 0.443-0.917, P=0.015), active PA (OR=0.538, 95% CI 0.335-0.865, P=0.01), and non-recurrent PA (OR=0.602, 95% CI 0.402-0.902, P=0.014). This genotype was also less frequent in the active PA subgroup (37.5% vs 52.7%, P=0.009) and the non-recurrent PA subgroup (40.2% vs 52.7%, P=0.013) compared to controls, while the rs5882 genotype A/A was less frequent in the non-recurrent PA subgroup (37.5% vs 46.2%, P=0.015). The authors conclude CETP rs708272 genotype G/A may be associated with decreased pituitary adenoma risk.

Original abstract

Aim: The aim was to evaluate the association of CETP (rs5882 and rs708272) single nucleotide polymorphisms with the presence, invasiveness, hormonal activity and recurrence of pituitary adenoma (PA).

Methods: The study group included 142 patients with PA and the control group, 753 healthy subjects. The genotyping of CETP (rs5882 and rs708272) was performed using a real-time PCR method.

Results: After statistical analysis we found that CETP rs708272 genotype G/A under the over-dominant model was associated with the decreased odds of PA (OR=0.637; 95%CI: 0.443-0.917; P=0.015), active PA (OR=0.538; 95%CI: 0.335-0.865; P =0.01) and non-recurrent PA (OR=0.602; 95% CI: 0.402 - 0.902; P =0.014). When compared to controls, the rs708272 genotype G/A was less frequent in the active PA subgroup (37.5% vs 52.7%, P =0.009) and the non-recurrent PA subgroup (40.2% vs 52.7%, P=0.013), while the rs5882 genotype A/A was less frequent in the non-recurrent PA subgroup (37.5% vs 46.2%, P=0.015).

Conclusion: Our study showed that CETP rs708272 genotype G/A may be associated with a decreased risk of PA.

Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.