Genetics
CETP variant rs708272 doubles the risk of myocardial infarction in men from Western Siberia (Biomolecules 2019)
Original title: Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia
This study analyzed the association of CETP TaqIB (rs708272), a variant actively investigated as a lipid metabolism risk factor, with lipid parameters and myocardial infarction (MI) risk in a white population of Western Siberia, Russia, drawn from the HAPIEE study. Among 3132 randomly selected participants, rs708272 genotype frequencies were 0.21 for AA, 0.49 for AG, and 0.30 for GG, with allele A frequency of 0.46. The G allele was associated with lower HDL-cholesterol and a higher atherogenicity index (both p less than 0.001). The G allele was significantly associated with MI risk in male participants (OR 1.96, 95% CI 1.208-3.178, p=0.008) and in the study population overall (OR 1.465, 95% CI 1.028-2.087, p=0.036). The authors conclude rs708272 is associated with MI risk in this population.
Original abstract
: The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial infarction in the population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45-69 years, males: 50%). In total, 3132 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs708272 was analyzed by RT-PCR via TaqMan single-nucleotide polymorphism (SNP) Genotyping Assays (Thermo Fisher Scientific, USA). The frequencies of rs708272 genotypes AA (homozygote), AG (heterozygote), and GG were 0.21, 0.49, and 0.30, respectively, in this population. Allele A frequency was 0.46. We found an association of allele G with low levels of high-density lipoprotein cholesterol and a high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively). Allele G was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.208-3.178, p = 0.008) and in the study population (odds ratio 1.465, 95% confidence interval 1.028-2.087, p = 0.036). Thus, rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia).
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.