Genetics
Two CETP gene variants raise coronary artery disease risk but do not predict restenosis after stenting (Arch Cardiol Mex 2022)
Original title: The rs4783961 and rs708272 genetic variants of the CETP gene are associated with coronary artery disease, but not with restenosis after coronary stenting
This study evaluated whether CETP gene polymorphisms -971 A/G (rs4783961) and Taq1B A/G (rs708272) are associated with coronary artery disease (CAD) and with restenosis after coronary stenting, genotyping 219 CAD patients (66 with restenosis, 153 without) and 607 controls. Polymorphism distribution was similar between patients with and without restenosis. However, comparing the whole CAD patient group to controls, the Taq1B G allele was associated with increased CAD risk under a dominant model (OR=1.48, P=0.032), and the -971 A allele was associated with increased CAD risk under codominant (OR=2.03, P=0.022), dominant (OR=1.83, P=0.008), and additive (OR=1.39, P=0.011) models. The AG haplotype was also associated with increased CAD risk (OR=1.28, P=0.03). The authors conclude both CETP polymorphisms are associated with increased CAD risk, but not with restenosis.
Original abstract
Objective: We evaluated whether cholesteryl ester transfer protein (CETP) gene polymorphisms are associated with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent.
Methods: Two polymorphisms of the CETP gene [-971 A/G (rs4783961), and Taq1B A/G (rs708272)] were genotyped by 5'exonuclease TaqMan assays in 219 patients with CAD (66 patients with restenosis and 153 without restenosis) and 607 control individuals.
Results: The distribution of polymorphisms was similar in patients with and without restenosis. However, when the whole group of patients (with and without restenosis) was compared to healthy controls, under dominant model, the G allele of the Taq1B A/G polymorphism was associated with increased risk of CAD (odds ratio [OR] = 1.48, pCDom = 0.032). In the same way, under codominant, dominant, and additive models, the A allele of the -971 A/G polymorphisms was associated with an increased risk of developing CAD (OR = 2.03, pCCo-dom = 0.022, OR = 1.83, pCDom = 0.008, and OR = 1.39, pCAdd = 0.011, respectively). In addition, the linkage disequilibrium showed that the "AG" haplotype was associated with increased risk of developing CAD (OR = 1.28, p = 0.03).
Conclusion: This study demonstrates that CETP Taq1B A/G and CETP -971 A/G polymorphisms are associated with an increased risk of developing CAD, but no association with restenosis was observed.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.