Genetics
Dietary antioxidant intake does not interact with the CETP Taq1B polymorphism to affect lipid profile or coronary stenosis severity (Food Sci Nutr 2024)
Original title: Dietary antioxidant status indices may not interact with CETP Taq1B polymorphism on lipid profile and severity of coronary artery stenosis in patients under coronary angiography
Because the association of the CETP Taq1B polymorphism with metabolic traits remains controversial, this cross-sectional study tested whether adherence to dietary antioxidant indices interacts with Taq1B genotype to affect coronary artery stenosis severity and serum lipids. Among 453 patients undergoing coronary angiography at Afshar Hospital, Yazd, between 2020 and 2021, dietary intake was assessed with a 178-item questionnaire, and Taq1B was genotyped by PCR-RFLP, finding genotype frequencies of 10.4% B1B1, 72.4% B1B2, and 17.2% B2B2. Two-way ANOVA found no significant interaction between Taq1B genotype and high adherence to the dietary antioxidant index, dietary antioxidant quality score, or dietary phytochemical index on total cholesterol, HDL, LDL, triglycerides, or Gensini and Syntax coronary stenosis scores. Lipid profile and stenosis scores did not differ significantly across Taq1B genotypes even among patients with high-adherence dietary indices, indicating no detectable gene-diet interaction for this polymorphism in this population.
Original abstract
The association of CETP Taq1B polymorphism with some metabolic traits is still controversial. The interaction of adherence to dietary indices with this polymorphism on the severity of coronary artery stenosis and serum lipid parameters needs to be investigated. This study aimed to test this hypothesis. This cross-sectional study included 453 patients who were referred from Afshar Hospital of Yazd and undergoing coronary angiography from 2020 to 2021. Dietary intake was evaluated by a 178-item validated and reliable dietary questionnaire. Dietary indices such as dietary antioxidant index (DAI), dietary antioxidant quality score (DAQS), and dietary phytochemical index (DPI) are determined according to dietary guidelines. The Taq1B variant was genotyped by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Two-way ANOVA was used to test the interaction between Taq1B polymorphism and dietary indices. The results of the frequency analysis of Taq1B genotypes showed that 10.4% were B1B1, 72.4% B1B2, and 17.2% B2B2. No significant interaction was found between the Taq1B variant with high adherence to DAQS, DAI, and DPI on total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG) levels, and Gensini score (GS) and Syntax score (SS). In high-adherence dietary indices, lipid profile and coronary artery stenosis scores did not differ significantly in Taq1B genotypes. Due to the insignificant results in this research, further studies are needed to investigate the role of Taq1B SNP in modulating dyslipidemia and the severity of the CAD in interaction with dietary indices.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.