Genetics
Traditional dietary pattern adherence modulates the CETP Taq1B link to triglyceride levels in angiography patients (Nutr J 2023)
Original title: Interaction between CETP Taq1B polymorphism and dietary patterns on lipid profile and severity of coronary arteries stenosis in patients under coronary angiography: a cross-sectional study
This cross-sectional study of 453 patients undergoing coronary angiography examined the interaction between CETP Taq1B polymorphism (rs708272) and dietary patterns, extracted via principal component analysis into a western dietary pattern (WDP) and a traditional dietary pattern (TDP), on lipid profile and coronary stenosis severity. Taq1B genotype frequencies were 10.4% B1B1, 72.4% B1B2, and 17.2% B2B2. Among patients with higher TDP adherence, a significant difference in triglycerides and the triglyceride to HDL-cholesterol ratio was observed across Taq1B genotypes (P=0.01 and P=0.03), and Taq1B showed a significant interaction with TDP for modulating these two measures (P=0.02 and P=0.04). Greater WDP adherence also showed a significant genotype difference in these measures (P=0.03) after adjustment. Other lipid components and coronary stenosis scores showed no relationship with Taq1B genotype or dietary pattern.
Original abstract
Aim: Evidence indicates there are still conflicts regarding CETP Taq1B polymorphism and coronary artery disease risk factors. Current findings about whether dietary patterns can change the relationship of the Taq1B on lipid profile and the severity of coronary arteries stenosis appears to be limited. The present research made an attempt to investigate this possible relationship.
Methods: This cross-sectional study involved 453 male and female participants with a mean age of 57 years. A validated 178-item food frequency questionnaire (FFQ) was used to assess dietary usual intake. Dietary patterns were extracted through principal component analysis (PCA). Taq1B variant was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Two-way ANOVA was used to test the interaction between Taq1B polymorphism and dietary patterns.
Results: Two dietary patterns were detected: the western dietary pattern (WDP) and the traditional dietary pattern (TDP). The frequency of Taq1B genotypes turned out to be 10.4, 72.4, and 17.2% for B1B1, B1B2, and B2B2, respectively. A significant difference was observed in TG and TG/HDL-C levels among TaqIB genotypes in higher adherence to TDP (P = 0.01 and P = 0.03, respectively). Taq1B showed a significant interaction with TDP for modulating TG levels and TG/HDL-C ratio (P = 0.02 and P = 0.04, respectively). Greater compliance to WDP demonstrated a significant difference in TG and TG/HDL-C levels across rs708272 genotypes (P = 0.03) after adjusting for confounding factors. Other lipid components and coronary arteries stenosis scores failed to show any relationship or significant difference across Taq1B genotypes or dietary patterns.
Conclusion: Adherence to TDP may adjust the association between the Taq1B variant and TG and TG/HDL-C levels in patients undergoing coronary angiography. To better understand the relationships, we suggest prospective studies in different race groups with multivariate approaches.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.