HDL biology
CETP activity exceeds that of adults and control children in kids on peritoneal dialysis for end-stage renal disease (Nephron 1996)
Original title: Increased activity of plasma cholesteryl ester transfer protein in children with end-stage renal disease receiving continuous ambulatory peritoneal dialysis
CETP activity was assayed in serum from children and adolescents on continuous ambulatory peritoneal dialysis (CAPD) for end-stage renal disease. These patients showed increased triglycerides, total cholesterol, LDL-cholesterol, apolipoprotein B, and apo B to apo A1 ratio, alongside decreased HDL-cholesterol. CETP activity in the CAPD children exceeded that seen in either adults or control children, and correlated with LDL-cholesterol, apolipoprotein B, and the ratios of total cholesterol to HDL-cholesterol, LDL-cholesterol to HDL-cholesterol, and apo B to apo A1. The authors suggest that elevated CETP activity in CAPD patients may result from increased synthesis in response to protein loss into the dialysis fluid, and may exacerbate atherosclerosis.
Original abstract
The activity of cholesteryl ester transfer protein (CETP) was assayed in sera of children and adolescents on continuous ambulatory peritoneal dialysis (CAPD) by coincubating lipoprotein-deficient samples with exogenous donor and acceptor lipoproteins. Serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio were increased, while the high-density lipoprotein cholesterol level was decreased. The CETP activity in children on CAPD exceeded that in either adults or control children, and was correlated with low-density lipoprotein cholesterol, apolipoprotein B, and total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol, and apolipoprotein B/apolipoprotein A1 ratios. The CETP activity in CAPD patients may be due to increased synthesis in response to a protein loss in the dialysis fluid and may exacerbate atherosclerosis.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.