LDL and apoB
Prebeta1-HDL concentration tracks LDL-cholesterol independent of CETP mass (Clin Chim Acta 2000)
Original title: Prebeta1-high-density lipoprotein (prebeta1-HDL) concentration can change with low-density lipoprotein-cholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP)
In 58 subjects with normal triglyceride and HDL-cholesterol levels, prebeta1-HDL concentration measured by native two-dimensional gel electrophoresis was positively correlated with LDL-cholesterol (r=0.529, P<0.0001) and with CETP mass (r=0.398, P<0.01). In 17 subjects resampled 1 to 6 months later, the change in prebeta1-HDL was positively correlated with the change in LDL-cholesterol (r=0.635, P<0.01), but not with the change in CETP mass (r=0.275). The authors conclude that prebeta1-HDL concentration changes with LDL-cholesterol independent of CETP, suggesting prebeta1-HDL reflects the balance among several regulatory factors including LDL-cholesterol and CETP.
Original abstract
To clarify whether prebeta1-high-density lipoprotein (prebeta1-HDL) concentration changes with low-density lipoprotein-cholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP), we determined prebeta1-HDL concentration by native two-dimensional gel electrophoresis in 58 subjects with normal triglyceride and HDL-cholesterol concentrations. We also measured LDL-C and CETP concentrations. In 17 subjects, a second blood sample was taken 1-6 months after the first. We found that prebeta1-HDL concentration was positively correlated with LDL-C concentration (r=0.529, P<0.0001) and with CETP mass (r=0.398, P<0.01). In 17 patients, Deltaprebeta1-HDL was positively correlated with DeltaLDL-C (r=0.635, P<0.01), but not with DeltaCETP mass (r=0.275). In conclusion, prebeta1-HDL concentration changes with LDL-C concentration independent of CETP. These results suggest that prebeta1-HDL concentration may reflect the balance between several regulatory factors, including LDL-C and CETP concentrations.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.