Genetics
CETP EcoN1 GG genotype linked to coronary heart disease risk in a Taiwanese population survey (Atherosclerosis 2001)
Original title: Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan
Genotyping two CETP genetic variations and four polymorphisms in a Taiwanese population by PCR and restriction digestion, the intron 14 splice site G-to-A change was very rare, while the control group showed predominant frequencies for the 405Ile allele (61%), 442Asp (97.7%), Taq1B(+) G allele (52%), Msp1(-) A allele (89%), and EcoN1(-) T allele (59.2%). Coronary heart disease patients had a higher frequency of the CETP EcoN1(+/+) GG genotype than controls (25.3% vs 13.6%, P=0.049). The Taq1B(-) A allele was associated with higher HDL-cholesterol and apoA1, the EcoN1(+) G allele with lower apoA1, and 442Gly with higher total and LDL cholesterol; paradoxically, 442Gly was also more frequent among subjects with HDL-cholesterol 65 mg/dl or higher than in the general population (5.2% vs 2.3%, P=0.04).
Original abstract
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester from high-density lipoprotein (HDL) to very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and chylomicron in exchange for triglycerides. Two CETP genetic variation and four polymorphisms are investigated by polymerase chain reaction (PCR) and restriction enzyme digestion in a population of Taiwan. The results show that a very rare variation frequency is found for CETP intron 14 splice site G-->A change. The population shows a predominant 405Ile allele (61%), 442Asp (97.7%), intron 1Taq1B(+) G allele (52%), intron 8 Msp1(-) A allele (89%) and intron 9 EcoN1(-) T allele (59.2%) in the control group. Patients with coronary heart disease (CHD) have more CETP EcoN1(+/+) GG genotype (25.3%) than the controls (13.6%) (P=0.049). The intron 1 Taq1B(-) A allele is associated with a high HDL cholesterol and apoA1 level, the EcoN1(+) G allele with a low apoA1 level and the 442Gly with both high total cholesterol and LDL cholesterol levels. Paradoxically, the 442Gly is also present with a higher frequency (5.2%) in HDL cholesterol > or =65 mg/dl group than that in the general population (2.3%) (P=0.04).
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.