Ancestry 101 items

Studies

• Landmark Omagari study first shows CETP-deficiency-driven high HDL cholesterol is not a longevity syndrome (Arterioscler Thromb Vasc Biol 1997)Arterioscler Thromb Vasc Biol · June 1997 9
• Phase 2 trial in 102 Japanese patients: obicetrapib 10mg on background statin cuts LDL-C by 45.8% and raises HDL-C by 159% (J Atheroscler Thromb 2024)J Atheroscler Thromb · April 2024 8
• Large Chinese biobank study finds genetically lower CETP activity raises HDL cholesterol but not vascular protection (JAMA Cardiol 2018)JAMA Cardiol · January 2018 8
• Mendelian randomisation across ancestries: CETP inhibition should protect against cardiovascular disease equally in East Asian and European populations (Nat Commun 2024)Nat Commun · June 2024 7
• A Polynesian-specific CETP missense variant lowers CETP activity by 27.9% and improves the lipid profile (HGG Adv 2023)HGG Adv · May 2023 7
• CETP -629C/A genotype predicts HDL-C but the CC genotype benefits most from atorvastatin's LDL-C-lowering effect in Chinese CHD patients (Med Sci Monit 2014)Med Sci Monit · December 2014 7
• CETP activity is 30 percent higher in South Asians than Europeans and tracks the full pattern of atherogenic dyslipidemia (Eur J Prev Cardiol 2014)Eur J Prev Cardiol · March 2014 7
• CETP I405V reverses direction: protective for longevity in Ashkenazi Jews but a risk allele in Chinese (PLoS One 2013)PLoS One · January 2013 7
• Heterozygous CETP-deficient HDL is remodeled toward more cholesteryl ester and less triglyceride but keeps normal antioxidative capacity (PLoS One 2012)PLoS One · January 2012 7
• CETP Taq1B B2 allele linked to lower coronary artery disease risk in Asian Indians (J Community Genet 2010)J Community Genet · March 2010 7
• A rare long CETP allele raises coronary artery disease risk nearly 7-fold in Corsican patients (Exp Mol Pathol 2006)Exp Mol Pathol · December 2006 7
• CETP D442G mutation raises HDL cholesterol in Vietnamese schoolgirls regardless of nutritional status (Pediatr Res 2005)Pediatr Res · December 2005 7
• Statins should benefit CETP TaqIB B1B1 carriers most, since they have the highest baseline CETP activity (J Atheroscler Thromb 2002)J Atheroscler Thromb · January 2002 7
• CETP-HDL relationships differ by sex, and CETP genotype does not explain Israel's low population HDL levels (Atherosclerosis 2000)Atherosclerosis · August 2000 7
• A novel hypothesis links high East Asian CETP deficiency prevalence to historical resistance against a liver-damaging parasite (Front Cell Dev Biol 2022)Front Cell Dev Biol · January 2022 6
• First Samoan genome-wide association study confirms CETP-HDL cholesterol link in a previously unstudied Polynesian population (J Hum Genet 2020)J Hum Genet · August 2020 6
• In 1,855 Ghanaian adults, CETP variant rs17231520 is the leading genetic signal for HDL cholesterol, replicating a finding rare in West African cohorts (Front Genet 2020)Front Genet · January 2020 6
• GWAS of 10,093 Indians finds CETP the primary genetic locus for metabolic syndrome, with a seven-variant haplotype as the strongest signal (Biomolecules 2019)Biomolecules · July 2019 6
• Rare CETP variants found in most Korean adults with extremely high HDL cholesterol, but do not alter cholesterol efflux (Sci Rep 2019)Sci Rep · July 2019 6
• CETP TaqIB B2B2 genotype blunts cholesterol-lowering response to simvastatin in Thai patients (Cardiovasc Ther 2017)Cardiovasc Ther · September 2017 6
• In Japanese patients, evacetrapib added to atorvastatin cuts LDL-C by 25.70% versus placebo and more than doubles HDL-C (Circ J 2017)Circ J · August 2017 6
• Evacetrapib monotherapy lowers LDL-C by 34.3% and raises HDL-C by 124% in Japanese patients with hypercholesterolemia (Circ J 2017)Circ J · June 2017 6
• In Japanese patients, adding anacetrapib to statins nearly doubles HDL-C and sustains lipid benefits through a 28-week extension (Atherosclerosis 2017)Atherosclerosis · March 2017 6
• CETP TaqIB and I405V variants strongly linked to centenarian status in Hainan, China (Asian Pac J Trop Med 2016)Asian Pac J Trop Med · July 2016 6
• In Japanese patients with familial hypercholesterolaemia, anacetrapib cuts LDL-C by nearly 30% versus placebo in 12 weeks (Atherosclerosis 2016)Atherosclerosis · March 2016 6
• Two CETP variants have opposite effects on coronary artery disease risk in the first such study in Saudi Arabians (Hum Genomics 2016)Hum Genomics · March 2016 6
• Active hepatitis C infection is associated with higher serum CETP and HDL triglyceride than after viral eradication (World J Hepatol 2016)World J Hepatol · February 2016 6
• The CETP B2 allele is linked to lower LDL cholesterol specifically in black, not white, South African women (Atherosclerosis 2015)Atherosclerosis · March 2015 6
• Combined CETP B1 and eNOS 4a alleles raise coronary artery disease risk up to 34-fold in Malay and Indian, but not Chinese, ethnic groups (Clin Appl Thromb Hemost 2016)Clin Appl Thromb Hemost · February 2015 6
• Ten CETP locus SNPs are among the strongest genetic determinants of HDL cholesterol variability in a Latvian population (Meta Gene 2014)Meta Gene · August 2014 6
• Dose-ranging phase 2 trial in Japanese patients shows evacetrapib 500 mg raises HDL-C by 136% and cuts CETP activity by 95% (Am J Cardiol 2014)Am J Cardiol · April 2014 6
• Ten-arm dose-ranging trial in Japanese patients shows anacetrapib raises HDL-C up to 159% and adds to the LDL-lowering of atorvastatin (Atherosclerosis 2013)Atherosclerosis · June 2013 6
• Meta-analysis of over 15,000 subjects finds the CETP TaqIB B1 allele raises coronary artery disease risk specifically in Han Chinese (Mol Biol Rep 2013)Mol Biol Rep · November 2012 6
• CETP TaqIB B1B1 men are most responsive to a high-carbohydrate low-fat diet's HDL-raising effect in young Chinese adults (J Nutr Biochem 2010)J Nutr Biochem · February 2010 6
• CETP locus generalizes as a blood-lipid determinant across black, Mexican American, and white US populations (Circ Cardiovasc Genet 2009)Circ Cardiovasc Genet · April 2009 6
• CETP TAQIB and I405V rare alleles are modestly associated with reduced obesity risk in Chinese adults, largely via HDL levels (Acta Diabetol 2009)Acta Diabetol · April 2009 6
• Two novel CETP protein variants identified through resequencing in individuals of Asian ancestry, both partly functional (Atherosclerosis 2009)Atherosclerosis · March 2008 6
• CETP is one of only four genes with consistent lipid effects across sex and race in the CARDIA cohort (Arterioscler Thromb Vasc Biol 2006)Arterioscler Thromb Vasc Biol · June 2006 6
• Full gene screening finds 12 novel CETP variants, three of which raise coronary heart disease risk in Chinese patients (Int J Cardiol 2005)Int J Cardiol · September 2005 6
• A newly characterized CETP promoter variant raises HDL cholesterol specifically in African Americans by weakening a transcription-factor binding site (Clin Genet 2004)Clin Genet · September 2004 6
• Review catalogs ten CETP mutations behind hyperalphalipoproteinemia in Japanese CETP-deficient subjects (J Atheroscler Thromb 2004)J Atheroscler Thromb · January 2004 6
• Japan CETP Study Group finds CETP activity is the strongest determinant of both HDL-C and LDL-C in 591 subjects (Metabolism 2003)Metabolism · December 2003 6
• Higher CETP activity in Hispanic postmenopausal women tracks with abdominal fat, not ethnicity itself (Metabolism 2003)Metabolism · March 2003 6
• CETP variants cannot explain why Asian Indians have both the highest heart disease rates and lowest HDL cholesterol in Singapore (Clin Genet 2003)Clin Genet · January 2003 6
• CETP TaqIB B2 allele is less common in African Americans than Caucasians, ruling it out as an explanation for higher HDL-C (Atherosclerosis 2002)Atherosclerosis · July 2002 6
• CETP EcoN1 GG genotype linked to coronary heart disease risk in a Taiwanese population survey (Atherosclerosis 2001)Atherosclerosis · December 2001 6
• Serum CETP is higher in women and higher still in Chinese myocardial infarction and stroke patients than in healthy controls (Clin Chim Acta 2001)Clin Chim Acta · March 2001 6
• Systematic review finds PCSK9, CETP and CDKN2B-AS1 polymorphisms among the strongest genetic contributors to myocardial infarction in Saudi Arabia (J Saudi Heart Assoc 2025)J Saudi Heart Assoc · January 2025 5
• PK/PD trial in 48 healthy Chinese volunteers shows obicetrapib behaves like it does in White participants, supporting the global phase 3 programme (J Clin Pharmacol 2024)J Clin Pharmacol · August 2024 5
• In a highly admixed population, four CETP gene variants explain part of the HDL-cholesterol variation across adolescents, adults and older adults (Clin Nutr ESPEN 2023)Clin Nutr ESPEN · October 2023 5
• Korean GWAS of 72,298 people finds a CETP variant significant for dyslipidaemia overall and a second one only in men (Lipids Health Dis 2022)Lipids Health Dis · November 2022 5
• A trans-ancestry GWAS in pregnant women finds the CETP locus approaches genome-wide significance for HDL cholesterol (J Clin Lipidol 2023)J Clin Lipidol · November 2022 5
• In two large Korean cohorts, whether CETP raises cholesterol with alcohol depends on a person's ALDH2 genotype (Sci Rep 2022)Sci Rep · September 2022 5
• CETP mutations are identified for the first time in South Indian patients with familial hypercholesterolemia (Clin Chim Acta 2022)Clin Chim Acta · January 2022 5
• Exome study in an underrepresented Mexican cohort finds a novel CETP variant, rs11076176, linked to higher risk of low HDL cholesterol (Front Genet 2022)Front Genet · January 2022 5
• Anacetrapib pharmacokinetics in healthy Chinese subjects closely match those seen in black and white populations (Adv Ther 2021)Adv Ther · June 2021 5
• CETP variant rs3764261 is linked to polypoidal choroidal vasculopathy in a Portuguese population, but not in a Singaporean cohort (Br J Ophthalmol 2021)Br J Ophthalmol · October 2020 5
• Fine-mapping in two Kuwaiti Arab cohorts flags rs1864163 in CETP as a candidate causal variant for HDL cholesterol (Hum Genet 2021)Hum Genet · September 2020 5
• CETP TaqIB genotype shapes HDL cholesterol but not diabetes risk in Southern Thai adults (Arch Med Res 2018)Arch Med Res · October 2018 5
• The lipid-lowering effect of anacetrapib is smaller in Black subjects than White subjects despite identical pharmacokinetics (J Clin Pharmacol 2018)J Clin Pharmacol · July 2018 5
• Meta-analysis identifies two CETP variants among the leading genetic risk factors for polypoidal choroidal vasculopathy in Asians (J Ophthalmol 2018)J Ophthalmol · January 2018 5
• A single dose of anacetrapib inhibits CETP equally well in young Japanese and white men, with a Japanese breakfast boosting exposure similarly (J Clin Pharmacol 2018)J Clin Pharmacol · September 2017 5
• CETP variant rs1800775 is associated with HDL cholesterol and total cholesterol, but not LDL, in pregnant Chinese women (J Clin Lipidol 2017)J Clin Lipidol · January 2017 5
• CETP c.*84G>A variant doubles coronary artery disease risk in South Indian patients (PLoS One 2016)PLoS One · January 2016 5
• Eight CETP gene polymorphisms show distinct HDL, LDL, and triglyceride associations in Kazak and Uyghur adults from Western China (Int J Environ Res Public Health 2015)Int J Environ Res Public Health · December 2015 5
• Flaxseed oil lowers small dense LDL alongside CETP and apoB concentrations after twelve weeks in Japanese men (Nutr J 2015)Nutr J · April 2015 5
• Review proposes historic hepatic schistosomiasis as a screening factor behind East Asia's unusually high rate of genetic CETP deficiency (Nutrients 2015)Nutrients · April 2015 5
• The CETP locus is one of only three individually significant lipid-associated SNPs confirmed in a first Algerian population genetics study (Int J Clin Exp Pathol 2015)Int J Clin Exp Pathol · January 2015 5
• CETP gene promoter variants show no association with longevity in two Han Chinese samples (Mol Biol Rep 2013)Mol Biol Rep · November 2013 5
• A Filipino GWAS finds suggestive CETP and TOM1 associations with HDL cholesterol and allelic heterogeneity at the CETP locus (J Lipid Res 2013)J Lipid Res · September 2013 5
• Absence of the CETP B2 allele doubles coronary artery disease risk, but only in ethnic Chinese Singaporeans (Lipids Health Dis 2013)Lipids Health Dis · June 2013 5
• Meta-analysis confirms CETP TaqIB polymorphism is linked to coronary artery disease in Chinese patients (J Zhejiang Univ Sci B 2012)J Zhejiang Univ Sci B · May 2012 5
• GWAS replication confirms CETP rs3764261 association with HDL-C in a 3,781-person Asian Indian cohort (PLoS One 2012)PLoS One · January 2012 5
• Three novel CETP gene mutations identified in Japanese patients with hyperalphalipoproteinemia (Clin Chim Acta 2012)Clin Chim Acta · November 2011 5
• CETP B1 allele raises coronary artery disease and diabetes risk independent of HDL-C in western Iran (Genet Test Mol Biomarkers 2011)Genet Test Mol Biomarkers · June 2011 5
• The PAGE study fails to replicate CETP rs1864163's HDL-C association across roughly 38,000 diverse-ancestry adults despite adequate power (PLoS Genet 2011)PLoS Genet · June 2011 5
• CETP B1B1 genotype nearly triples coronary heart disease risk in a South Indian population (Clin Chim Acta 2009)Clin Chim Acta · January 2009 5
• CETP TaqIB predicts HDL cholesterol in one Chinese ethnic minority but not in neighboring Han Chinese (J Investig Med 2008)J Investig Med · August 2008 5
• CETP promoter -1337 CC genotype doubles coronary atherosclerosis risk in Japanese familial hypercholesterolaemia patients (Clin Sci 2006)Clin Sci (Lond) · November 2006 5
• CETP I405V and healthy aging link does not replicate in Italian centenarians (Mech Ageing Dev 2005)Mech Ageing Dev · January 2005 5
• CETP deficiency raises HDL cholesterol in Japanese centenarians but does not affect longevity (J Mol Med (Berl) 2003)J Mol Med (Berl) · February 2003 5
• CETP mass varies widely in healthy Japanese people with very high HDL cholesterol (Intern Med 2002)Intern Med · May 2002 5
• CETP I405V, not Taq1B, predicts smaller LDL particle size in Japanese patients (Atherosclerosis 2002)Atherosclerosis · April 2002 5
• The first CETP TaqI genotyping in Egyptians finds a B1:B2 allele split of 0.65:0.35, matching the pattern shared by other Arab-descended populations (Eur J Clin Pharmacol 2002)Eur J Clin Pharmacol · March 2002 5
• A dominant-negative CETP promoter mutation cuts transcriptional activity to 8% of wild type in Japanese hyperalphalipoproteinemia (ATVB 2001)Arterioscler Thromb Vasc Biol · June 2001 5
• CETP TaqIB genotype linked to macroangiopathy risk in Japanese patients with type 2 diabetes (Atherosclerosis 2001)Atherosclerosis · May 2001 5
• A rare CETP intron 14 mutation, usually found only in Japanese, is identified in a Finnish family with high HDL cholesterol (Arterioscler Thromb Vasc Biol 1998)Arterioscler Thromb Vasc Biol · April 1998 5
• A novel intron 10 splice mutation causes exon 10 skipping and disrupts downstream splicing in CETP deficiency (J Lipid Res 1996)J Lipid Res · October 1996 5
• Iranian case-control study finds no direct link between CETP polymorphism rs708272 and coronary artery disease, but flags a CETP-activity/HDL-C interaction (BMC Cardiovasc Disord 2022)BMC Cardiovasc Disord · June 2022 4
• Atorvastatin exposure is about twice as high in healthy Korean volunteers as in Caucasians, partly explained by eight variants including one in CETP (Front Genet 2022)Front Genet · January 2022 4
• GWAS of 49,915 Koreans finds CETP among the lipid genes shared by metabolically unhealthy normal-weight and obese phenotypes (Sci Rep 2021)Sci Rep · January 2021 4
• In a north Indian CAD study, CETP rs708272 alone was not significant, but showed a synergistic interaction with physical inactivity (BMC Cardiovasc Disord 2020)BMC Cardiovasc Disord · July 2020 4
• A genome-wide meta-analysis in Hispanic populations confirms CETP as a genome-wide-significant locus for HDL cholesterol (Sci Rep 2016)Sci Rep · January 2016 4
• ANGPTL3 abnormalities outnumber CETP abnormalities in Japanese hyperalphalipoproteinemic subjects (Clin Chim Acta 2008)Clin Chim Acta · September 2008 4
• Combining three CETP polymorphisms predicts lipid profile better than any single variant in South Indians (Clin Chim Acta 2007)Clin Chim Acta · July 2006 4
• Novel splice-site mutation in the CETP gene found in a patient with hyperalphalipoproteinemia (Metabolism 2002)Metabolism · March 2002 4
• CETP D442G and TaqIB variants track with higher HDL cholesterol in Taiwanese Chinese, but the link weakens with obesity (Hum Genet 2001)Hum Genet · November 2001 4
• Heterozygous CETP D442G carrier shows apolipoprotein E trapped in HDL at triple the level of other carriers (Clin Chim Acta 2000)Clin Chim Acta · November 2000 4
• CETP TaqI RFLP frequencies are remarkably uniform across Italian, Greek, and other Caucasian populations (Hum Hered 1994)Hum Hered · January 1994 4
• CETP TaqIB polymorphism shows no link to metabolic syndrome in Southern Thai subjects (Biochem Genet 2015)Biochem Genet · May 2015 3
• CETP TaqIB and LPL Ser447Ter polymorphisms show no association with ischaemic stroke in Greek patients (Neurosci Lett 2005)Neurosci Lett · August 2005 3